Protein: RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)

Gene: RPAB5, POLR2L
Organism: Homo sapiens
Interactions: 164
UniProt ID: P62875

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005665 - RNA polymerase II, core complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

180269

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

7

4

High-throughput

0.963

High

621621

RPB3
DNA-directed RNA polymerase II subunit RPB3

5

4

Small-scale

0.922

High

722933

RPB2
DNA-directed RNA polymerase II subunit RPB2

5

9

Small-scale

0.922

High

983719

RPC2
DNA-directed RNA polymerase III subunit RPC2

5

9

Small-scale

0.916

High

983709

RPA2
DNA-directed RNA polymerase I subunit RPA2

4

9

High-throughput

0.892

High

983717

RPC5
DNA-directed RNA polymerase III subunit RPC5

4

1

High-throughput

0.892

High

190870

RPA34
DNA-directed RNA polymerase I subunit RPA34

2

0

High-throughput

0.748

High

192808

RPB4
DNA-directed RNA polymerase II subunit RPB4

6

1

Small-scale

0.734

High

621854

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

2

Small-scale

0.723

High

976083

RPB7
DNA-directed RNA polymerase II subunit RPB7

5

4

Small-scale

0.716

High

912048

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

5

1

Small-scale

0.714

High

339967

RPA1
DNA-directed RNA polymerase I subunit RPA1

5

11

Small-scale

0.712

High

430622

RPC4
DNA-directed RNA polymerase III subunit RPC4

5

1

High-throughput

0.712

High

667257

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

11

Small-scale

0.709

High

983698

RPAP1
RNA polymerase II-associated protein 1

4

1

Small-scale

0.700

High

983712

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

4

3

High-throughput

0.694

High

165033

RPC1
DNA-directed RNA polymerase III subunit RPC1

4

11

High-throughput

0.691

High

912170

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

4

4

High-throughput

0.691

High

983736

RPC8
DNA-directed RNA polymerase III subunit RPC8

4

4

High-throughput

0.691

High

958929

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

2

High-throughput

0.667

High

983701

RPA49
DNA-directed RNA polymerase I subunit RPA49

3

1

High-throughput

0.667

High

983720

PIHD1
PIH1 domain-containing protein 1

4

0

High-throughput

0.664

High

983702

RPC6
DNA-directed RNA polymerase III subunit RPC6

3

1

High-throughput

0.662

High

287451

RPC9
DNA-directed RNA polymerase III subunit RPC9

3

1

High-throughput

0.650

High

316277

RECQ5
ATP-dependent DNA helicase Q5

3

1

High-throughput

0.650

High

983676

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

1

High-throughput

0.650

High

983735

RPC10
DNA-directed RNA polymerase III subunit RPC10

3

5

High-throughput

0.650

High

983645

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

48937

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.638

High

335979

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.638

High

64860

RCCD1
RCC1 domain-containing protein 1

3

0

High-throughput

0.634

High

983708

GPN2
GPN-loop GTPase 2

4

4

High-throughput

0.630

High

130432

SPT5H
Transcription elongation factor SPT5

2

1

High-throughput

0.628

High

983690

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

3

High-throughput

0.628

High

983695

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

2

1

High-throughput

0.628

High

516833

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

4

High-throughput

0.611

High

131918

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

1

High-throughput

0.611

High

787744

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

5

High-throughput

0.611

High

923488

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

1

High-throughput

0.611

High

983664

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

2

2

High-throughput

0.611

High

983670

SPT6H
Transcription elongation factor SPT6

2

1

High-throughput

0.611

High

983725

RPA12
DNA-directed RNA polymerase I subunit RPA12

2

6

High-throughput

0.611

High

983730

GPN3
GPN-loop GTPase 3

3

4

High-throughput

0.609

High

983693

NACC1
Nucleus accumbens-associated protein 1

2

1

High-throughput

0.606

High

799839

COIL
Coilin

2

0

High-throughput

0.606

High

681783

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

186370

RPC7
DNA-directed RNA polymerase III subunit RPC7

2

1

High-throughput

0.601

High

983697

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

High-throughput

0.601

High

983710

GPN1
GPN-loop GTPase 1

2

4

High-throughput

0.601

High

506007

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

0

High-throughput

0.585

High

316381

RMP
Unconventional prefoldin RPB5 interactor 1

2

0

High-throughput

0.585

High

983673

SKAP1
Src kinase-associated phosphoprotein 1

2

0

High-throughput

0.585

High

983696

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.585

High

983704

RPAP3
RNA polymerase II-associated protein 3

2

0

High-throughput

0.585

High

983727

UXT
Protein UXT

2

0

High-throughput

0.585

High

262508

MCE1
mRNA-capping enzyme

2

2

High-throughput

0.584

High

954782

PSA6
Proteasome subunit alpha type-6

2

0

High-throughput

0.580

High

983657

PCH2
Pachytene checkpoint protein 2 homolog

2

0

High-throughput

0.580

High

983714

F217B
Protein FAM217B

2

0

High-throughput

0.580

High

983675

PHC2
Polyhomeotic-like protein 2

1

1

High-throughput

0.573

High

983687

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

1

High-throughput

0.573

High

983692

SPAG5
Sperm-associated antigen 5

1

1

High-throughput

0.573

High

259753

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

983703

MED28
Mediator of RNA polymerase II transcription subunit 28

2

0

High-throughput

0.559

High

229320

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.549

High

983652

ASPP2
Apoptosis-stimulating of p53 protein 2

1

0

High-throughput

0.549

High

983678

BANP
Protein BANP

1

0

High-throughput

0.549

High

983718

THAP1
THAP domain-containing protein 1

1

0

High-throughput

0.549

High

983654

GRB7
Growth factor receptor-bound protein 7

2

0

High-throughput

0.547

High

628741

TBP
TATA-box-binding protein

1

1

High-throughput

0.536

High

895431

SPB8
Serpin B8

1

4

High-throughput

0.536

High

983662

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.536

High

983700

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

4

High-throughput

0.536

High

983732

SPB13
Serpin B13

1

4

High-throughput

0.536

High

983737

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

354940

CHK2
Serine/threonine-protein kinase Chk2

1

0

High-throughput

0.518

High

983660

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

216659

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

276577

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.513

High

423630

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

477986

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480086

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

574208

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

774987

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

791262

SYUA
Alpha-synuclein

1

0

High-throughput

0.513

High

839538

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

911823

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.513

High

973877

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

983644

DSG1
Desmoglein-1

1

0

High-throughput

0.513

High

983653

PKP1
Plakophilin-1

1

0

High-throughput

0.513

High

983667

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

983669

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

983677

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

983721

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

983722

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.513

High

983723

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.513

High

983724

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

High-throughput

0.513

High

983731

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.513

High

289250

SPB7
Serpin B7

1

5

High-throughput

0.489

High

424495

PAI2
Plasminogen activator inhibitor 2

1

4

High-throughput

0.489

High

983674

SPA12
Serpin A12

1

4

High-throughput

0.489

High

983688

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

983691

SPB12
Serpin B12

1

4

High-throughput

0.489

High

983694

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

239561

MED14
Mediator of RNA polymerase II transcription subunit 14

1

3

High-throughput

0.479

High

371687

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406014

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

979455

H4
Histone H4

1

1

High-throughput

0.479

High

983646

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.479

High

983706

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.479

High

983726

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.479

High

983729

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.479

High

877595

CCN3
CCN family member 3

1

0

Small-scale

0.460

High

983713

EXOS5
Exosome complex component RRP46

1

0

High-throughput

0.460

High

326319

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

345634

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

472605

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

567355

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

606580

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

651259

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

878919

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

937694

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

947137

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

948505

ELOF1
Transcription elongation factor 1 homolog

1

0

Small-scale

0.458

High

983648

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

983649

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

983650

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.458

High

983651

CUL3
Cullin-3

1

0

High-throughput

0.458

High

983655

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

983658

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.458

High

983659

IKBB
NF-kappa-B inhibitor beta

1

0

High-throughput

0.458

High

983661

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.458

High

983666

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

983668

INT5
Integrator complex subunit 5

1

0

High-throughput

0.458

High

983671

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

983672

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

983683

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

983684

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

983685

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

983686

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.458

High

983705

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

983707

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

983711

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

983716

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

983728

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

983733

INT6
Integrator complex subunit 6

1

0

High-throughput

0.458

High

505952

MYZAP
Myocardial zonula adherens protein

1

1

High-throughput

0.445

High

983663

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

516796

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

983665

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

983715

PDRG1
p53 and DNA damage-regulated protein 1

2

0

High-throughput

0.318

High

353218

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.316

High

983734

SNX7
Sorting nexin-7

1

0

High-throughput

0.282

High

556909

MYH7
Myosin-7

1

0

High-throughput

0.279

Low

983647

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.279

Low

983656

CDSN
Corneodesmosin

1

0

High-throughput

0.279

Low

983679

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.279

Low

983681

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

983682

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

182108

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.249

Low

293521

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

983680

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

983689

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

983699

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025