HitPredict

Interactor 1: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Interactor 2: CSK23 (Q8NEV1)
Casein kinase II subunit alpha 3 (CK II alpha 3) (EC 2.7.11.1) (Casein kinase II alpha 1 polypeptide pseudogene)
Gene: CSNK2A3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~Pkinase, PB1~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0008284 - positive regulation of cell population proliferation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 391
+	Hs
		934118 KPCZ_HUMAN (1-592): 0: 688: 100.00		CSK21_HUMAN (1-391): 1.68e-138: 401: 98.47
+	Hs
		783975 KPCI_HUMAN (1-592): 0: 654: 69.87		CSK21_HUMAN (1-391): 1.68e-138: 401: 98.47
+	Hs
		784048 KPCI_HUMAN (1-592): 0: 654: 69.87		CSK23_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		623866 KPCL_HUMAN (6-585): 0: 568: 33.49		CDK2_HUMAN (36-330): 1.23e-124: 363: 29.74
+	Hs
		681782 AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39		CSK21_HUMAN (1-391): 1.68e-138: 401: 98.47
+	Hs
		616697 KS6B1_HUMAN (227-590): 1.48e-144: 430: 35.60		CSK21_HUMAN (1-391): 1.68e-138: 401: 98.47
+	Hs
		682166 AKT2_HUMAN (148-582): 5.85e-155: 455: 36.12		CDK3_HUMAN (36-331): 1.46e-122: 358: 31.27
+	Rn
		576046 AKT1_RAT (172-582): 4.45e-154: 452: 36.39		GSK3B_RAT (10-389): 2.55e-118: 351: 26.34
+	Hs
		682150 AKT2_HUMAN (148-582): 5.85e-155: 455: 36.12		GSK3B_HUMAN (39-381): 8.2e-110: 329: 28.85
+	Hs
		681743 AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39		GSK3B_HUMAN (39-381): 8.2e-110: 329: 28.85
+	Hs
		836099 AKT3_HUMAN (171-582): 2.36e-153: 450: 37.24		GSK3B_HUMAN (39-381): 8.2e-110: 329: 28.85
+	Hs
		568590 KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06		GSK3B_HUMAN (39-381): 8.2e-110: 329: 28.85
+	Hs
		850635 KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47		CSK21_HUMAN (1-391): 1.68e-138: 401: 98.47
+	Hs
		850684 KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47		CSK23_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		586628 KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47		CSK22_HUMAN (1-334): 8.26e-120: 352: 84.78
+	Dm
		437053 KPC3_DROME (6-207): 1.15e-27: 120: 19.37		CSK2A_DROME (6-338): 6.22e-130: 378: 86.19
+	Hs
		566279 KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63		CSK22_HUMAN (1-334): 8.26e-120: 352: 84.78
+	Hs
		566330 KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63		GSK3B_HUMAN (39-381): 8.2e-110: 329: 28.85