Protein: RBX2
RING-box protein 2 (Rbx2) (EC 2.3.2.27) (EC 2.3.2.32) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)

Gene: RBX2, RNF7
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9UBF6

Gene Ontology (top 5):
GO:0005507 - copper ion binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1371889

CUL5
Cullin-5

27

20

Small-scale

0.993

High

906809

UB2D1
Ubiquitin-conjugating enzyme E2 D1

12

20

Small-scale

0.979

High

1380511

UBE2F
NEDD8-conjugating enzyme UBE2F

9

20

Small-scale

0.968

High

1112757

CUL1
Cullin-1

7

20

Small-scale

0.953

High

982350

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.945

High

144198

UBE2C
Ubiquitin-conjugating enzyme E2 C

4

20

Small-scale

0.899

High

1147298

ELOB
Elongin-B

4

1

Small-scale

0.893

High

957223

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

Small-scale

0.885

High

1162709

UBE2S
Ubiquitin-conjugating enzyme E2 S

3

20

Small-scale

0.861

High

1115114

CUL4A
Cullin-4A

3

20

Small-scale

0.854

High

1115472

CUL4B
Cullin-4B

3

20

Small-scale

0.847

High

883349

UB2R1
Ubiquitin-conjugating enzyme E2 R1

3

20

Small-scale

0.845

High

1310802

CUL9
Cullin-9

2

9

High-throughput

0.776

High

1113009

CUL2
Cullin-2

2

20

Small-scale

0.767

High

1114533

CUL3
Cullin-3

2

20

Small-scale

0.755

High

1451554

ASB6
Ankyrin repeat and SOCS box protein 6

5

4

Small-scale

0.714

High

1402158

RB40C
Ras-related protein Rab-40C

4

11

Small-scale

0.698

High

1458374

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1383787

TTC28
Tetratricopeptide repeat protein 28

1

2

High-throughput

0.691

High

1434861

ASB7
Ankyrin repeat and SOCS box protein 7

4

7

Small-scale

0.687

High

1458372

FBW1A
F-box/WD repeat-containing protein 1A

3

14

Small-scale

0.664

High

1281075

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

1

0

High-throughput

0.663

High

1405983

SPSB2
SPRY domain-containing SOCS box protein 2

3

9

Small-scale

0.662

High

1458377

ASB1
Ankyrin repeat and SOCS box protein 1

3

11

Small-scale

0.657

High

1086748

RB40B
Ras-related protein Rab-40B

3

10

Small-scale

0.656

High

1146406

LRC41
Leucine-rich repeat-containing protein 41

3

1

Small-scale

0.650

High

1400504

ASB2
Ankyrin repeat and SOCS box protein 2

3

2

Small-scale

0.650

High

1448614

TULP4
Tubby-related protein 4

3

2

Small-scale

0.650

High

1458378

WSB1
WD repeat and SOCS box-containing protein 1

3

6

Small-scale

0.650

High

335197

ARI2
E3 ubiquitin-protein ligase ARIH2

1

9

Small-scale

0.647

High

957539

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

Small-scale

0.647

High

996033

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

1371210

GLMN
Glomulin

1

1

Small-scale

0.647

High

1458366

RBX2
RING-box protein 2

1

13

Small-scale

0.647

High

861822

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

5

Small-scale

0.629

High

998082

CSK21
Casein kinase II subunit alpha

2

3

Small-scale

0.629

High

995322

CSK2B
Casein kinase II subunit beta

3

0

Small-scale

0.627

High

155969

SOCS3
Suppressor of cytokine signaling 3

2

13

Small-scale

0.619

High

1244464

DCNL2
DCN1-like protein 2

1

9

Small-scale

0.618

High

1310001

DCNL3
DCN1-like protein 3

1

9

Small-scale

0.618

High

1364793

DCNL4
DCN1-like protein 4

1

9

Small-scale

0.618

High

1413519

DCNL5
DCN1-like protein 5

1

9

Small-scale

0.618

High

155133

SOCS2
Suppressor of cytokine signaling 2

2

12

Small-scale

0.611

High

1361066

ASB13
Ankyrin repeat and SOCS box protein 13

2

8

High-throughput

0.611

High

1382398

SPSB4
SPRY domain-containing SOCS box protein 4

2

10

Small-scale

0.611

High

1147141

ELOC
Elongin-C

2

2

Small-scale

0.602

High

273317

SOCS5
Suppressor of cytokine signaling 5

2

10

High-throughput

0.601

High

1245016

SPSB3
SPRY domain-containing SOCS box protein 3

2

12

High-throughput

0.601

High

1291257

CAND1
Cullin-associated NEDD8-dissociated protein 1

2

6

High-throughput

0.601

High

1356714

TGFA1
Transforming growth factor-beta receptor-associated protein 1

2

3

High-throughput

0.601

High

1360866

SOCS4
Suppressor of cytokine signaling 4

2

14

High-throughput

0.601

High

1398166

PCMD1
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1

2

1

High-throughput

0.601

High

1431603

VPS11
Vacuolar protein sorting-associated protein 11 homolog

2

1

High-throughput

0.601

High

1437201

CSN7B
COP9 signalosome complex subunit 7b

2

2

High-throughput

0.601

High

1450301

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

2

1

High-throughput

0.601

High

1452782

WSB2
WD repeat and SOCS box-containing protein 2

2

8

High-throughput

0.601

High

1119535

PEBB
Core-binding factor subunit beta

2

1

Small-scale

0.595

High

1458379

NEMO
NF-kappa-B essential modulator

1

12

High-throughput

0.594

High

1438289

DEFM
Peptide deformylase, mitochondrial

2

0

High-throughput

0.576

High

1417012

CAR14
Caspase recruitment domain-containing protein 14

1

2

Small-scale

0.552

High

908793

MAT1
CDK-activating kinase assembly factor MAT1

1

1

High-throughput

0.541

High

1278503

TRI46
Tripartite motif-containing protein 46

1

6

High-throughput

0.541

High

1389449

CHFR
E3 ubiquitin-protein ligase CHFR

1

2

High-throughput

0.541

High

1420190

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

4

High-throughput

0.541

High

155182

SOCS7
Suppressor of cytokine signaling 7

1

9

High-throughput

0.536

High

156089

SOCS6
Suppressor of cytokine signaling 6

1

13

High-throughput

0.536

High

163182

CHK1
Serine/threonine-protein kinase Chk1

1

2

High-throughput

0.536

High

253790

UGDH
UDP-glucose 6-dehydrogenase

1

1

High-throughput

0.536

High

885913

KC1E
Casein kinase I isoform epsilon

1

5

High-throughput

0.536

High

1054807

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

1154221

TBCE
Tubulin-specific chaperone E

1

1

High-throughput

0.536

High

1357994

RN138
E3 ubiquitin-protein ligase RNF138

1

3

High-throughput

0.536

High

1363100

DDB2
DNA damage-binding protein 2

1

7

High-throughput

0.536

High

1384502

SPSB1
SPRY domain-containing SOCS box protein 1

1

10

Small-scale

0.536

High

1418011

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

1

3

High-throughput

0.536

High

1435548

ASB8
Ankyrin repeat and SOCS box protein 8

1

9

High-throughput

0.536

High

1449361

CISH
Cytokine-inducible SH2-containing protein

1

12

High-throughput

0.536

High

1458376

ASB3
Ankyrin repeat and SOCS box protein 3

1

4

High-throughput

0.536

High

1093733

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.518

High

1361075

ASB12
Ankyrin repeat and SOCS box protein 12

1

9

Small-scale

0.515

High

339187

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.513

High

619124

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.513

High

873759

GSH0
Glutamate--cysteine ligase regulatory subunit

1

0

High-throughput

0.513

High

897094

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

1251634

KAT3
Kynurenine--oxoglutarate transaminase 3

1

0

High-throughput

0.513

High

1387041

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.513

High

1411518

PDD2L
Programmed cell death protein 2-like

1

0

High-throughput

0.513

High

1458367

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

0

High-throughput

0.513

High

933909

GEM
GTP-binding protein GEM

1

10

High-throughput

0.508

High

1117317

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

Small-scale

0.501

High

1308065

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

1

High-throughput

0.501

High

1360837

ASB11
Ankyrin repeat and SOCS box protein 11

1

6

Small-scale

0.501

High

1400044

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

5

High-throughput

0.501

High

1401949

ERBIN
Erbin

1

2

Small-scale

0.501

High

1438530

ABC3G
DNA dC->dU-editing enzyme APOBEC-3G

1

1

High-throughput

0.501

High

1447604

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.494

High

551308

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.493

High

1311884

DHX40
Probable ATP-dependent RNA helicase DHX40

1

4

High-throughput

0.489

High

1387729

TBC31
TBC1 domain family member 31

1

3

High-throughput

0.489

High

1368503

CBP
CREB-binding protein

1

3

Small-scale

0.481

High

1450411

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

1

Small-scale

0.481

High

1348714

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

0

Small-scale

0.480

High

822893

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.479

High

840092

CASP3
Caspase-3

1

4

Small-scale

0.479

High

935229

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

1057279

PRDX1
Peroxiredoxin-1

1

6

Small-scale

0.479

High

1101919

SKP2
S-phase kinase-associated protein 2

1

10

Small-scale

0.479

High

1117516

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

4

High-throughput

0.479

High

1360887

ASB10
Ankyrin repeat and SOCS box protein 10

1

5

High-throughput

0.479

High

1434127

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1458368

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1458369

FBW1B
F-box/WD repeat-containing protein 11

1

14

Small-scale

0.479

High

1458370

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.479

High

1458375

ASB4
Ankyrin repeat and SOCS box protein 4

1

5

High-throughput

0.479

High

190507

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.445

High

273236

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

5

High-throughput

0.445

High

1405814

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.445

High

1454683

KLH42
Kelch-like protein 42

1

12

High-throughput

0.445

High

1458373

KLDC2
Kelch domain-containing protein 2

1

13

High-throughput

0.445

High

1249717

CLC4G
C-type lectin domain family 4 member G

1

5

High-throughput

0.417

High

533859

GHR
Growth hormone receptor

1

1

Small-scale

0.408

High

351030

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.279

Low

1203975

DALD3
DALR anticodon-binding domain-containing protein 3

1

0

High-throughput

0.279

Low

1363506

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

0

High-throughput

0.279

Low

1458371

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025