HitPredict

Interactor 1: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Interactor 2: ANR54 (Q6NXT1)
Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein)
Gene: ANKRD54

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	28514442, 33961781, 32707033, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 659 Hs			1 300
+	Hs
		788998 TEC_HUMAN (5-658): 0: 711: 53.43		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Mm
		976833 ITK_MOUSE (4-657): 0: 682: 48.72		ANR54_MOUSE (1-300): 4.51e-70: 220: 92.00
+	Hs
		433389 YES_HUMAN (133-653): 5.05e-180: 523: 32.77		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		523028 SRC_HUMAN (164-653): 1.04e-178: 520: 35.14		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Mm
		639458 LYN_MOUSE (154-653): 7.83e-170: 496: 35.12		ANR54_MOUSE (1-300): 4.51e-70: 220: 92.00
+	Hs
		411697 LCK_HUMAN (207-653): 1.53e-171: 500: 38.14		ANK3_HUMAN (83-297): 6.75e-61: 211: 20.31
+	Hs
		433832 LYN_HUMAN (154-653): 1.58e-168: 493: 34.92		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		411885 LCK_HUMAN (207-653): 1.53e-171: 500: 38.14		KDIS_HUMAN (1-260): 6.37e-60: 208: 15.89
+	Hs
		433730 LYN_HUMAN (154-653): 1.58e-168: 493: 34.92		ANK3_HUMAN (83-297): 6.75e-61: 211: 20.31
+	Hs
		433701 LYN_HUMAN (154-653): 1.58e-168: 493: 34.92		ANK2_HUMAN (82-297): 7.44e-60: 208: 19.62
+	Hs
		434071 LYN_HUMAN (154-653): 1.58e-168: 493: 34.92		KDIS_HUMAN (1-260): 6.37e-60: 208: 15.89
+	Hs
		846484 BLK_HUMAN (156-653): 1.82e-164: 482: 35.98		ANR54_HUMAN (1-300): 7.42e-69: 217: 100.00
+	Hs
		337406 ABL1_HUMAN (181-659): 2.77e-165: 505: 38.76		DAPK1_HUMAN (103-298): 1.54e-38: 146: 19.19
+	Hs
		434072 LYN_HUMAN (154-653): 1.58e-168: 493: 34.92		ANR50_HUMAN (124-297): 4.84e-39: 148: 21.17
+	Dm
		337696 SRC64_DROME (169-653): 9.9e-163: 480: 34.62		TNKS_DROME (24-295): 3.24e-30: 121: 15.83