HitPredict

Interactor 1: EXOS9 (Q06265)
Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)
Gene: EXOSC9

Interactor 2: EXOS2 (Q13868)
Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)
Gene: EXOSC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.956

The method score is based on:

Property Details
Experiments 26496610, 27173435, 24981860, 33961781, 12788944, 17412707, 11719186
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ECR1_N~RNase_PH, ECR1_N~RNase_PH_C
Common GO terms GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
and 14 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 439
Hs

1 293
+ Hs
+ Hs
+ Sp
+ At
+ Hs
+ Dm
+ Sc
+ Sp
+ At
+ Pf
+ At
+ Dm
+ Dm
+ Sp
+ At
+ At
+ Tb
+ Sc
+ Sc
+ Tb

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Last updated: 15 Jul 2024