HitPredict

Interactor 1: EXOS9 (Q06265)
Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)
Gene: EXOSC9

Interactor 2: DI3L1 (Q8TF46)
DIS3-like exonuclease 1 (EC 3.1.13.1)
Gene: DIS3L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	26496610, 24981860, 20531386
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, RNB~RNase_PH, OB_Dis3~RNase_PH_C
Common GO terms	GO:0000175 - 3'-5'-RNA exonuclease activity GO:0000177 - cytoplasmic exosome (RNase complex) GO:0003723 - RNA binding GO:0005829 - cytosol GO:0006396 - RNA processing and 1 others more... GO:0006401 - RNA catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Hs			1 1054
+	Hs
		1257149 EXOS8_HUMAN (1-275): 1.68e-86: 267: 26.98		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		1063744 EXOS7_HUMAN (1-284): 9.95e-83: 257: 26.12		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		1257153 EXOS4_HUMAN (14-277): 2.36e-51: 175: 14.76		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		986739 EXOS9_HUMAN (1-439): 3.86e-146: 425: 100.00		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Hs
		1284999 EXOS8_HUMAN (1-275): 1.68e-86: 267: 26.98		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Hs
		1063785 EXOS7_HUMAN (1-284): 9.95e-83: 257: 26.12		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Dm
		1250326 Q8T4A9_DROME (3-338): 1.66e-93: 289: 32.49		Q9VC93_DROME (7-988): 0: 943: 31.52
+	Sp
		252320 RRP45_SCHPO (2-287): 1.15e-87: 270: 42.31		DIS3_SCHPO (5-972): 0: 941: 32.54
+	Hs
		1342631 EXOS4_HUMAN (14-277): 2.36e-51: 175: 14.76		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Dm
		1100453 Q29QQ9_DROME (1-284): 6e-72: 230: 25.68		Q9VC93_DROME (7-988): 0: 943: 31.52
+	Sp
		740351 RRP43_SCHPO (3-257): 1.28e-66: 215: 27.03		DIS3_SCHPO (5-972): 0: 941: 32.54
+	Sc
		984317 RRP45_YEAST (2-290): 7.5e-80: 250: 33.78		RRP44_YEAST (2-971): 0: 893: 31.47
+	Dm
		1362696 Q9VK19_DROME (19-272): 1.71e-47: 165: 17.05		Q9VC93_DROME (7-988): 0: 943: 31.52
+	At
		96521 RRP41_ARATH (20-276): 3.77e-51: 174: 16.73		F4INI6_ARATH (1-972): 0: 934: 31.24
+	Dm
		1362699 Q9VW53_DROME (27-319): 9.7e-45: 160: 18.67		Q9VC93_DROME (7-988): 0: 943: 31.52
+	Sp
		194782 RRP41_SCHPO (12-274): 2.41e-46: 161: 18.22		DIS3_SCHPO (5-972): 0: 941: 32.54
+	Sp
		223963 RRP42_SCHPO (4-268): 7.17e-34: 130: 18.06		DIS3_SCHPO (5-972): 0: 941: 32.54
+	Sc
		993688 RRP42_YEAST (4-267): 2.09e-41: 149: 16.43		RRP44_YEAST (2-971): 0: 893: 31.47
+	Sc
		809596 RRP41_YEAST (20-276): 9.25e-40: 144: 16.23		RRP44_YEAST (2-971): 0: 893: 31.47
+	Pf
		1212338 Q8ID62_PLAF7 (4-282): 4.35e-78: 252: 30.47		Q8IDB6_PLAF7 (6-301): 2.09e-67: 248: 16.57