HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: AKAP6 (Q13023)
A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP)
Gene: AKAP6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 2319
+	Hs
		593978 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		AKAP6_HUMAN (1-2319): 0: 2655: 100.00
+	Hs
		362270 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		AKAP6_HUMAN (1-2319): 0: 2655: 100.00
+	Hs
		440522 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		AKAP6_HUMAN (1-2319): 0: 2655: 100.00
+	Hs
		987621 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SPTN1_HUMAN (913-1371): 1.08e-24: 115: 12.58
+	Hs
		987548 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SPTB2_HUMAN (620-1335): 1.01e-21: 106: 8.79
+	Hs
		772723 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH9_HUMAN (809-1373): 1.05e-19: 99.3: 11.21
+	Hs
		987557 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		DYST_HUMAN (803-1297): 5.81e-09: 64.2: 11.73
+	Hs
		440069 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SPTN1_HUMAN (913-1371): 1.08e-24: 115: 12.58
+	Hs
		440030 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SPTB2_HUMAN (620-1335): 1.01e-21: 106: 8.79
+	Hs
		174688 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SPTN2_HUMAN (841-1378): 1.02e-19: 99.7: 11.25
+	Hs
		362286 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		SPTN1_HUMAN (913-1371): 1.08e-24: 115: 12.58
+	Hs
		440243 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MACF1_HUMAN (492-1261): 3.47e-11: 71.5: 10.78
+	Hs
		440036 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		DYST_HUMAN (803-1297): 5.81e-09: 64.2: 11.73
+	Hs
		1117374 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		SPTN1_HUMAN (913-1371): 1.08e-24: 115: 12.58
+	Hs
		1028778 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		SPTB2_HUMAN (620-1335): 1.01e-21: 106: 8.79
+	Hs
		440414 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MYH9_HUMAN (809-1373): 1.05e-19: 99.3: 11.21
+	Hs
		117127 J3QRU1_HUMAN (71-215): 6.6e-12: 65.8: 16.33		MYH9_HUMAN (809-1373): 1.05e-19: 99.3: 11.21
+	Hs
		463006 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		MYH9_HUMAN (809-1373): 1.05e-19: 99.3: 11.21
+	Hs
		1040391 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		DYST_HUMAN (803-1297): 5.81e-09: 64.2: 11.73
+	Hs
		1040304 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		DYST_HUMAN (803-1297): 5.81e-09: 64.2: 11.73