Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2
Interactor 2: GARE1 (Q9H706)
GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
Gene: GAREM1
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 0.60 | 0.758 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25416956, 28514442, 31980649, 20936779, 32296183, 33961781, 21988832, unassigned1304, unassigned2173, 21706016, unassigned3799 |
| Identification Methods | two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005886 - plasma membrane GO:0007173 - epidermal growth factor receptor signaling pathway |
| Homologous interactions | 6 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
