Protein: GRAP2
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)

Gene: GRAP2
Organism: Homo sapiens
Interactions: 104
UniProt ID: O75791

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

292831

LCP2
Lymphocyte cytosolic protein 2

20

20

Small-scale

0.991

High

292833

GAB1
GRB2-associated-binding protein 1

7

20

Small-scale

0.963

High

292883

GAB2
GRB2-associated-binding protein 2

6

20

Small-scale

0.948

High

292868

PTN23
Tyrosine-protein phosphatase non-receptor type 23

4

20

Small-scale

0.905

High

292796

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.902

High

292861

ITCH
E3 ubiquitin-protein ligase Itchy homolog

3

17

High-throughput

0.861

High

292870

SH24A
SH2 domain-containing protein 4A

2

20

High-throughput

0.783

High

292799

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

292857

BLNK
B-cell linker protein

2

20

Small-scale

0.768

High

292794

STABP
STAM-binding protein

9

1

Small-scale

0.752

High

292869

GARE1
GRB2-associated and regulator of MAPK protein 1

7

9

High-throughput

0.745

High

292819

DYN2
Dynamin-2

1

20

High-throughput

0.723

High

292886

ZSC21
Zinc finger and SCAN domain-containing protein 21

5

7

High-throughput

0.717

High

292814

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

5

17

Small-scale

0.716

High

292803

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

292805

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.691

High

292804

CD28
T-cell-specific surface glycoprotein CD28

3

5

Small-scale

0.687

High

292813

CDC27
Cell division cycle protein 27 homolog

3

12

High-throughput

0.667

High

292834

TNIP1
TNFAIP3-interacting protein 1

3

20

High-throughput

0.667

High

292841

TRI68
E3 ubiquitin-protein ligase TRIM68

3

16

High-throughput

0.667

High

292860

APC16
Anaphase-promoting complex subunit 16

3

2

High-throughput

0.667

High

292862

SNX18
Sorting nexin-18

3

20

High-throughput

0.667

High

292876

CDC23
Cell division cycle protein 23 homolog

3

11

High-throughput

0.667

High

292879

ANC2
Anaphase-promoting complex subunit 2

3

7

High-throughput

0.667

High

292811

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.654

High

292800

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

Small-scale

0.647

High

292810

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

292823

GRB2
Growth factor receptor-bound protein 2

1

19

Small-scale

0.647

High

292826

SOS2
Son of sevenless homolog 2

1

20

Small-scale

0.647

High

292835

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

292881

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

20

Small-scale

0.647

High

292858

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

2

20

Small-scale

0.644

High

292859

RBPMS
RNA-binding protein with multiple splicing

2

2

High-throughput

0.640

High

292818

INAR2
Interferon alpha/beta receptor 2

3

0

High-throughput

0.634

High

221071

SPY2
Protein sprouty homolog 2

2

20

High-throughput

0.633

High

292821

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

20

High-throughput

0.632

High

220328

LAT
Linker for activation of T-cells family member 1

2

10

Small-scale

0.624

High

292795

ABL1
Tyrosine-protein kinase ABL1

1

19

Small-scale

0.618

High

292816

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

292878

APC5
Anaphase-promoting complex subunit 5

2

2

High-throughput

0.611

High

292797

MOS
Proto-oncogene serine/threonine-protein kinase mos

2

9

High-throughput

0.606

High

292808

ZN250
Zinc finger protein 250

2

5

High-throughput

0.606

High

292820

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

7

High-throughput

0.606

High

292839

KPRP
Keratinocyte proline-rich protein

2

3

High-throughput

0.606

High

292848

RAVR1
Ribonucleoprotein PTB-binding 1

2

10

High-throughput

0.606

High

292873

ZN319
Zinc finger protein 319

2

2

High-throughput

0.606

High

292812

PBLD
Phenazine biosynthesis-like domain-containing protein

2

0

High-throughput

0.580

High

292832

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

High-throughput

0.576

High

292853

RIN3
Ras and Rab interactor 3

2

20

High-throughput

0.576

High

178065

FYB1
FYN-binding protein 1

1

20

Small-scale

0.575

High

160956

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.561

High

131627

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

17

High-throughput

0.560

High

159439

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.560

High

292793

BAG4
BAG family molecular chaperone regulator 4

1

7

High-throughput

0.560

High

292806

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.560

High

292809

GATA1
Erythroid transcription factor

1

1

High-throughput

0.560

High

292815

ETV5
ETS translocation variant 5

1

10

High-throughput

0.560

High

292827

TLE5
TLE family member 5

1

1

High-throughput

0.560

High

292829

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

1

High-throughput

0.560

High

292830

TRAF1
TNF receptor-associated factor 1

1

12

High-throughput

0.560

High

292838

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

20

High-throughput

0.560

High

292840

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

20

High-throughput

0.560

High

292846

KRA13
Keratin-associated protein 1-3

1

9

High-throughput

0.560

High

292850

LNX2
Ligand of Numb protein X 2

1

20

High-throughput

0.560

High

292852

PNMA1
Paraneoplastic antigen Ma1

1

10

High-throughput

0.560

High

292854

LNX1
E3 ubiquitin-protein ligase LNX

1

20

High-throughput

0.560

High

292855

CCHCR
Coiled-coil alpha-helical rod protein 1

1

10

High-throughput

0.560

High

292856

ZN526
Zinc finger protein 526

1

4

High-throughput

0.560

High

292866

KR411
Keratin-associated protein 4-11

1

7

High-throughput

0.560

High

292872

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.560

High

292880

IKZF3
Zinc finger protein Aiolos

1

9

High-throughput

0.560

High

292887

MAGD1
Melanoma-associated antigen D1

1

6

High-throughput

0.560

High

292792

CCDB1
Cyclin-D1-binding protein 1

1

0

Small-scale

0.549

High

180132

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

12

High-throughput

0.541

High

292807

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.541

High

292822

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.541

High

292863

KR412
Keratin-associated protein 4-12

1

8

High-throughput

0.541

High

292842

RINT1
RAD50-interacting protein 1

1

0

High-throughput

0.536

High

292874

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.536

High

292802

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

292798

ALBU
Albumin

1

1

High-throughput

0.536

High

292871

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

1

4

High-throughput

0.536

High

292844

Q7Z783
Protein sprouty homolog 2

1

20

High-throughput

0.515

High

292865

PECR
Peroxisomal trans-2-enoyl-CoA reductase

1

0

High-throughput

0.513

High

292828

GOGA2
Golgin subfamily A member 2

1

17

High-throughput

0.512

High

292817

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

14

Small-scale

0.501

High

292824

RACK1
Small ribosomal subunit protein RACK1

1

9

Small-scale

0.501

High

292825

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

Small-scale

0.501

High

76480

B4DXD0
Translin associated factor X interacting protein 1

1

1

High-throughput

0.494

High

292837

TXIP1
Translin-associated factor X-interacting protein 1

1

1

High-throughput

0.481

High

292847

LAX1
Lymphocyte transmembrane adapter 1

1

1

Small-scale

0.479

High

292867

APC1
Anaphase-promoting complex subunit 1

1

2

High-throughput

0.479

High

292877

APC7
Anaphase-promoting complex subunit 7

1

12

High-throughput

0.479

High

292882

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

7

High-throughput

0.479

High

292884

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.460

High

292875

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.458

High

292864

MND1
Meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.445

High

292845

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.426

High

292801

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

292849

IHO1
Interactor of HORMAD1 protein 1

1

0

High-throughput

0.292

High

292851

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.292

High

292885

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.292

High

292843

BEND5
BEN domain-containing protein 5

1

0

High-throughput

0.282

High

292836

TMED2
Transmembrane emp24 domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025