Interactor 1: VAMP2 (P63027)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2
Interactor 2: STX1A (Q16623)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.971 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 10100611, 9030619, 32296183, 10449403, 7553862, 12093152, 23100443, 11832227, 20798282, unassigned1304 |
| Identification Methods | pull down, two hybrid, far western blotting, affinity chromatography technology, x-ray crystallography, anti bait coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, validated two hybrid |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | SNARE~Synaptobrevin, Synaptobrevin~Syntaxin |
| Common GO terms | GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006887 - exocytosis and 13 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
