HitPredict

Interactor 1: STX1A (Q24547)
Syntaxin-1A (dSynt1)
Gene: Syx1A

Interactor 2: Q7JYX5 (Q7JYX5)
Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1)
Gene: Vamp7

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	15710747, 28403141, 22036573, 38944040
Identification Methods	two hybrid, affinity chromatography technology, two hybrid fragment pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005765 - lysosomal membrane GO:0006887 - exocytosis GO:0006906 - vesicle fusion and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 291 Dm			1 218
+	Rn
		746118 STX1A_RAT (3-290): 2.6e-76: 236: 68.40		VAMP7_RAT (1-218): 2.89e-85: 253: 51.84
+	Hs
		908014 STX1A_HUMAN (3-290): 2.05e-75: 233: 68.40		VAMP7_HUMAN (1-218): 9.61e-85: 252: 52.29
+	Hs
		908006 STX4_HUMAN (3-287): 3.64e-58: 189: 40.41		VAMP7_HUMAN (1-218): 9.61e-85: 252: 52.29
+	Hs
		908007 STX3_HUMAN (3-267): 2.32e-57: 187: 58.87		VAMP7_HUMAN (1-218): 9.61e-85: 252: 52.29
+	Mm
		147440 STX1A_MOUSE (3-290): 3.2e-76: 235: 68.75		SC22B_MOUSE (23-206): 1.19e-64: 200: 20.54
+	Hs
		280213 STX1A_HUMAN (3-290): 2.05e-75: 233: 68.40		SC22B_HUMAN (23-206): 1.19e-64: 200: 20.54
+	Hs
		280135 STX2_HUMAN (3-287): 1.31e-73: 229: 60.35		SC22B_HUMAN (23-206): 1.19e-64: 200: 20.54
+	Dm
		121793 STX1A_DROME (1-291): 4.27e-78: 240: 100.00		M9PGI6_DROME (24-206): 7.07e-57: 181: 25.54
+	Dm
		305560 STX1A_DROME (1-291): 4.27e-78: 240: 100.00		O77434_DROME (24-206): 1.12e-56: 180: 25.54
+	Dm
		1174554 STX1A_DROME (1-291): 4.27e-78: 240: 100.00		Q9W3M8_DROME (5-179): 1.89e-50: 164: 22.16
+	Hs
		280189 STX4_HUMAN (3-287): 3.64e-58: 189: 40.41		SC22B_HUMAN (23-206): 1.19e-64: 200: 20.54
+	Dm
		614903 STX1A_DROME (1-291): 4.27e-78: 240: 100.00		SYB_DROME (97-208): 1.45e-35: 124: 16.07
+	Hs
		192248 STX3_HUMAN (3-267): 2.32e-57: 187: 58.87		YKT6_HUMAN (22-179): 2.7e-54: 173: 27.67
+	Hs
		278503 STX1A_HUMAN (3-290): 2.05e-75: 233: 68.40		VAMP4_HUMAN (124-193): 1.01e-13: 67.4: 40.00
+	Hs
		1159628 STX1A_HUMAN (3-290): 2.05e-75: 233: 68.40		VAMP8_HUMAN (124-193): 2.61e-11: 60.1: 35.71
+	Rn
		746121 STX1A_RAT (3-290): 2.6e-76: 236: 68.40		VAMP8_RAT (124-189): 3.95e-10: 57: 34.85
+	Hs
		746221 STX2_HUMAN (3-287): 1.31e-73: 229: 60.35		VAMP8_HUMAN (124-193): 2.61e-11: 60.1: 35.71
+	Hs
		278494 STX4_HUMAN (3-287): 3.64e-58: 189: 40.41		VAMP4_HUMAN (124-193): 1.01e-13: 67.4: 40.00
+	Hs
		278497 STX3_HUMAN (3-267): 2.32e-57: 187: 58.87		VAMP4_HUMAN (124-193): 1.01e-13: 67.4: 40.00
+	Hs
		1087264 STX4_HUMAN (3-287): 3.64e-58: 189: 40.41		VAMP8_HUMAN (124-193): 2.61e-11: 60.1: 35.71