HitPredict

Interactor 1: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030054 - cell junction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1748 Hs			1 1128
+	Hs
		990915 ZO1_HUMAN (1-1748): 0: 925: 100.00		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Hs
		1043700 PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		280042 MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		1043768 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		1296387 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Hs
		280009 MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61		TNKS1_HUMAN (808-1080): 1.68e-44: 178: 12.84
+	Mm
		1143380 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		DAPK1_MOUSE (824-1047): 9.29e-35: 146: 15.63
+	Hs
		280069 MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61		TNKS2_HUMAN (893-1127): 6.78e-43: 172: 14.54
+	Mm
		103602 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		ANK3_MOUSE (681-1011): 3.26e-23: 109: 12.69
+	Dm
		677732 DLG1_DROME (1-118): 1.51e-24: 114: 25.00		Q9W2I0_DROME (858-1064): 2.14e-25: 116: 15.71
+	Mm
		1194495 UNC5B_MOUSE (1634-1718): 4.24e-11: 70.1: 43.53		DAPK1_MOUSE (824-1047): 9.29e-35: 146: 15.63
+	Dm
		113976 M9PB30_DROME (1108-1664): 5.31e-24: 113: 15.83		M9PB30_DROME (335-930): 6.34e-12: 72.8: 9.61
+	Hs
		280085 MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61		DAPLE_HUMAN (33-349): 6.45e-16: 85.6: 16.36
+	Hs
		306907 UNC5C_HUMAN (1635-1728): 1.98e-13: 77.8: 47.37		DAPK1_HUMAN (791-1011): 1.31e-20: 100: 13.12
+	Hs
		862073 UNC5B_HUMAN (1634-1718): 3.49e-11: 70.5: 44.71		DAPK1_HUMAN (791-1011): 1.31e-20: 100: 13.12
+	Hs
		1354501 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		ANR50_HUMAN (836-995): 6.95e-17: 88.7: 16.88