HitPredict

Interactor 1: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24255178
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1748 Hs			1 1088
+	Hs
		325703 ZO1_HUMAN (1-1748): 0: 925: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		1232507 PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		990961 ZO1_HUMAN (1-1748): 0: 925: 100.00		MRCKB_HUMAN (658-1007): 1.11e-70: 261: 40.34
+	Hs
		1020225 PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1246440 INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		280078 MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1344959 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		325806 PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325709 PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325820 INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		280011 MPDZ_HUMAN (31-489): 8.85e-18: 92.6: 13.61		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325824 DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325929 ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Ce
		1089258 Q20398_CAEEL (31-800): 9.99e-97: 340: 19.06		AKT1_CAEEL (532-1060): 4.03e-133: 416: 21.90
+	Mm
		554913 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92
+	Mm
		933108 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		KAPCB_MOUSE (638-1022): 3.87e-133: 409: 31.62
+	Mm
		1143553 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		KS6A2_MOUSE (519-973): 2.65e-79: 277: 19.79
+	Hs
		942348 DLG4_HUMAN (1-112): 2.58e-27: 122: 29.92		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Mm
		936586 DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92		ROCK2_MOUSE (640-1008): 1.72e-66: 247: 37.17