Protein: NC2A
Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)

Gene: NC2A, DRAP1
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q14919

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001046 - core promoter sequence-specific DNA binding
GO:0001091 - RNA polymerase II general transcription initiation factor binding
GO:0005634 - nucleus
GO:0006366 - transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1031898

NC2B
Protein Dr1

16

20

Small-scale

0.985

High

1133363

DPOE3
DNA polymerase epsilon subunit 3

5

20

High-throughput

0.937

High

628781

TBP
TATA-box-binding protein

4

2

Small-scale

0.886

High

670078

NFYB
Nuclear transcription factor Y subunit beta

2

20

High-throughput

0.834

High

1133346

NC2A
Dr1-associated corepressor

2

6

High-throughput

0.826

High

1133348

TAF9
Transcription initiation factor TFIID subunit 9

6

4

High-throughput

0.741

High

1133360

TAF9B
Transcription initiation factor TFIID subunit 9B

4

4

High-throughput

0.705

High

681814

RBTN2
Rhombotin-2

4

1

High-throughput

0.700

High

1025100

TF2B
Transcription initiation factor IIB

3

2

High-throughput

0.675

High

140270

SDCB1
Syntenin-1

3

1

High-throughput

0.671

High

1133349

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.665

High

1133358

H2B1N
Histone H2B type 1-N

1

3

High-throughput

0.665

High

1133354

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

4

1

High-throughput

0.623

High

749032

RL9
Large ribosomal subunit protein uL6

2

0

High-throughput

0.580

High

1133356

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

288089

FOXH1
Forkhead box protein H1

1

11

Small-scale

0.561

High

1133353

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.553

High

1006410

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.550

High

222083

NCK2
Cytoplasmic protein NCK2

1

0

High-throughput

0.549

High

1029680

FOXK2
Forkhead box protein K2

1

9

High-throughput

0.536

High

1133369

FOXD3
Forkhead box protein D3

1

10

High-throughput

0.536

High

405459

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.518

High

842961

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

0

High-throughput

0.518

High

1133364

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1133352

LNX2
Ligand of Numb protein X 2

1

1

High-throughput

0.512

High

1133365

DJB11
DnaJ homolog subfamily B member 11

1

4

High-throughput

0.508

High

1133370

TTF2
Transcription termination factor 2

1

5

Small-scale

0.508

High

1133357

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.481

High

1133371

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

179206

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

2

Small-scale

0.479

High

315591

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

408879

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

606775

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

1133347

SMAD2
Mothers against decapentaplegic homolog 2

1

2

High-throughput

0.479

High

1133367

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1133359

PKHF2
Pleckstrin homology domain-containing family F member 2

1

2

High-throughput

0.464

High

790050

ZEB1
Zinc finger E-box-binding homeobox 1

1

0

Small-scale

0.460

High

485150

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

533937

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

629872

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

422113

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

1133368

FEZ2
Fasciculation and elongation protein zeta-2

1

1

Small-scale

0.439

High

1056733

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

861164

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.437

High

959159

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.437

High

1133350

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

765525

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

1133351

Q8N381
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

1

High-throughput

0.417

High

330155

VENTX
Homeobox protein VENTX

1

5

High-throughput

0.407

High

1133362

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

1133366

MO4L1
Mortality factor 4-like protein 1

2

0

High-throughput

0.316

High

1012184

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.279

Low

1133355

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.265

Low

522663

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

High-throughput

0.249

Low

1016015

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

1133361

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

0

High-throughput

0.238

Low

771122

APJ
Apelin receptor

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025