HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: DREB (Q16643)
Drebrin (Developmentally-regulated brain protein)
Gene: DBN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.848

Property	Details
Experiments	30890647, 30021884, 34349018
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005737 - cytoplasm GO:0007015 - actin filament organization GO:0015629 - actin cytoskeleton GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 649
+	Hs
		952855 ACTB_HUMAN (4-377): 0: 598: 94.12		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		993194 ACTG_HUMAN (4-377): 0: 598: 94.39		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		977706 ACTA_HUMAN (1-377): 0: 597: 98.41		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		995882 ACTC_HUMAN (1-377): 0: 599: 100.00		DBNL_HUMAN (3-464): 9.9e-75: 248: 29.98
+	Hs
		953170 ACTB_HUMAN (4-377): 0: 598: 94.12		DBNL_HUMAN (3-464): 9.9e-75: 248: 29.98
+	Ce
		534399 ACT2_CAEEL (1-377): 0: 600: 94.43		Q9XUT0_CAEEL (4-619): 3.41e-47: 178: 16.46
+	Hs
		952994 ACTB_HUMAN (4-377): 0: 598: 94.12		CTTB2_HUMAN (131-627): 2.71e-32: 136: 14.70
+	Hs
		215916 ACTC_HUMAN (1-377): 0: 599: 100.00		SYNJ1_HUMAN (126-645): 3.15e-29: 126: 9.77
+	Dm
		1014444 ACT6_DROME (1-377): 0: 594: 92.84		TITIN_DROME (173-542): 3.1e-27: 120: 13.80
+	Dm
		1014448 ACT6_DROME (1-377): 0: 594: 92.84		Q9VDF4_DROME (152-461): 2.5e-18: 91: 14.82
+	Dm
		56405 ACT6_DROME (1-377): 0: 594: 92.84		A1ZA72_DROME (119-643): 3.13e-17: 88.7: 8.97