HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: DREB (Q16643)
Drebrin (Developmentally-regulated brain protein)
Gene: DBN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	28514442, 33961781, 34079125, 37071682, 36652389, 39358380, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0015629 - actin cytoskeleton GO:0030863 - cortical cytoskeleton GO:0098978 - glutamatergic synapse
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 649
+	Hs
		1160646 ACTBL_HUMAN (2-375): 0: 735: 91.71		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		506950 POTEI_HUMAN (1-375): 0: 731: 91.20		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		993194 ACTG_HUMAN (1-375): 0: 601: 98.93		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		995623 ACTC_HUMAN (2-375): 0: 592: 94.12		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		977706 ACTA_HUMAN (2-375): 0: 591: 94.12		DREB_HUMAN (1-649): 3.27e-95: 308: 100.00
+	Hs
		953170 ACTB_HUMAN (1-375): 0: 603: 100.00		DBNL_HUMAN (3-464): 9.9e-75: 248: 29.98
+	Hs
		995882 ACTC_HUMAN (2-375): 0: 592: 94.12		DBNL_HUMAN (3-464): 9.9e-75: 248: 29.98
+	Ce
		534399 ACT2_CAEEL (2-375): 0: 600: 98.13		Q9XUT0_CAEEL (4-619): 3.41e-47: 178: 16.46
+	Hs
		952994 ACTB_HUMAN (1-375): 0: 603: 100.00		CTTB2_HUMAN (131-627): 2.71e-32: 136: 14.70
+	Sc
		587330 ACT_YEAST (1-375): 0: 591: 88.80		ABP1_YEAST (4-512): 1.46e-30: 128: 13.41
+	Hs
		215916 ACTC_HUMAN (2-375): 0: 592: 94.12		SYNJ1_HUMAN (126-645): 3.15e-29: 126: 9.77
+	Dm
		1014444 ACT6_DROME (2-375): 0: 594: 95.99		TITIN_DROME (173-542): 3.1e-27: 120: 13.80
+	Dm
		1014448 ACT6_DROME (2-375): 0: 594: 95.99		Q9VDF4_DROME (152-461): 2.5e-18: 91: 14.82
+	Dm
		56405 ACT6_DROME (2-375): 0: 594: 95.99		A1ZA72_DROME (119-643): 3.13e-17: 88.7: 8.97