HitPredict - High confidence protein-protein interactions

Interactor 1: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Interactor 2: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	18082144, 32296183, 35271311, 36508083, 19211765, 12628923, 10512750, 15882073, 24013921, unassigned1304
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology, protein kinase assay, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 27 others more... GO:0005886 - plasma membrane GO:0005956 - protein kinase CK2 complex GO:0006302 - double-strand break repair GO:0006915 - apoptotic process GO:0006974 - DNA damage response GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0016055 - Wnt signaling pathway GO:0016301 - kinase activity GO:0016605 - PML body GO:0017148 - negative regulation of translation GO:0030177 - positive regulation of Wnt signaling pathway GO:0030307 - positive regulation of cell growth GO:0032435 - negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0045732 - positive regulation of protein catabolic process GO:0048511 - rhythmic process GO:0050821 - protein stabilization GO:0051726 - regulation of cell cycle GO:0051879 - Hsp90 protein binding GO:0070822 - Sin3-type complex GO:0075342 - symbiont-mediated disruption of host cell PML body GO:0106310 - protein serine kinase activity GO:1901797 - negative regulation of signal transduction by p53 class mediator GO:1905337 - positive regulation of aggrephagy GO:1905818 - regulation of chromosome separation GO:2000042 - negative regulation of double-strand break repair via homologous recombination GO:2001234 - negative regulation of apoptotic signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	391
Hs

1	391

Service provided by Combinatics, Japan

Last updated: 11Aug2025