HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	25281560, 36089195, 25634209, 37823591, 37797621
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-RING_6
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046982 - protein heterodimerization activity
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 777
+	Hs
		1017155 H33_HUMAN (1-136): 1.45e-61: 186: 96.32		BARD1_HUMAN (1-777): 0: 649: 100.00
+	Hs
		998722 H31_HUMAN (1-136): 1.85e-62: 189: 100.00		MPP8_HUMAN (119-549): 6.78e-52: 196: 15.51
+	Hs
		1017152 H33_HUMAN (1-136): 1.45e-61: 186: 96.32		MPP8_HUMAN (119-549): 6.78e-52: 196: 15.51
+	Hs
		1016968 H33_HUMAN (1-136): 1.45e-61: 186: 96.32		BCOR_HUMAN (152-543): 7.62e-45: 176: 23.93
+	Hs
		998263 H31_HUMAN (1-136): 1.85e-62: 189: 100.00		ANK3_HUMAN (130-480): 1.69e-43: 173: 14.09
+	Hs
		998221 H31_HUMAN (1-136): 1.85e-62: 189: 100.00		ANK2_HUMAN (135-447): 8.22e-34: 142: 8.92
+	Hs
		1030664 H32_HUMAN (1-136): 3.8e-61: 186: 99.27		ANK2_HUMAN (135-447): 8.22e-34: 142: 8.92
+	Hs
		883586 CENPA_HUMAN (9-133): 7.51e-45: 144: 50.00		ANR11_HUMAN (280-544): 1.61e-42: 169: 25.74
+	Hs
		998678 H31_HUMAN (1-136): 1.85e-62: 189: 100.00		TONSL_HUMAN (423-532): 1.16e-20: 99.8: 46.90
+	Hs
		1161999 H31T_HUMAN (1-136): 9.24e-62: 187: 97.06		TONSL_HUMAN (423-532): 1.16e-20: 99.8: 46.90
+	Hs
		1017115 H33_HUMAN (1-136): 1.45e-61: 186: 96.32		TONSL_HUMAN (423-532): 1.16e-20: 99.8: 46.90
+	Hs
		1258914 H32_HUMAN (1-136): 3.8e-61: 186: 99.27		TONSL_HUMAN (423-532): 1.16e-20: 99.8: 46.90