HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	15136563, 15664194, 16415179, 16096645, 15308690
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HAT_KAT11~Histone
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2414 Hs			1 129
+	Hs
		998866 EP300_HUMAN (1-2414): 0: 1113: 100.00		H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83
+	Hs
		391671 EP300_HUMAN (1-2414): 0: 1113: 100.00		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		555430 EP300_HUMAN (1-2414): 0: 1113: 100.00		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Mm
		70932 EP300_MOUSE (1-2414): 0: 1090: 93.01		H2A3_MOUSE (1-127): 5.35e-65: 195: 95.28
+	Hs
		391923 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		555661 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	At
		286875 GCN5_ARATH (1000-1159): 2.86e-39: 158: 27.98		H2A3_ARATH (1-129): 1.33e-62: 189: 73.08
+	Hs
		1066979 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Hs
		631492 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83
+	Hs
		1067038 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83
+	Hs
		1067005 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64
+	Hs
		391554 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		555299 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		555470 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Sp
		391996 YK82_SCHPO (990-1155): 2.19e-28: 126: 20.48		H2A1_SCHPO (1-121): 5.12e-54: 167: 83.74
+	Hs
		555434 BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		554260 MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		555463 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Sc
		392189 GCN5_YEAST (1074-1156): 2.55e-12: 73.6: 38.55		H2A1_YEAST (16-129): 1.56e-52: 163: 78.95
+	Sc
		392549 GCN5_YEAST (1074-1156): 2.55e-12: 73.6: 38.55		H2A2_YEAST (16-129): 1.63e-52: 163: 78.95