HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: KCC2A (P11798)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: Camk2a

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	27507650, 28706196, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0014069 - postsynaptic density GO:0045202 - synapse GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1340 Mm			1 478
+	Hs
		1039019 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		KCC2G_HUMAN (1-475): 0: 617: 71.71
+	Hs
		1039152 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		KCC2D_HUMAN (2-475): 0: 552: 87.55
+	Mm
		99917 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		KCC2B_MOUSE (1-475): 1.19e-178: 513: 71.06
+	Rn
		88547 D3ZCL8_RAT (16-1292): 0: 1012: 98.91		KCC2A_RAT (1-478): 0: 569: 100.00
+	Hs
		1038915 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		KCC2B_HUMAN (218-475): 9.21e-59: 206: 42.44
+	Hs
		809299 IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97		KCC2G_HUMAN (1-475): 0: 617: 71.71
+	Mm
		515255 IQGA1_MOUSE (219-731): 1.36e-107: 377: 13.95		KCC2A_MOUSE (1-478): 0: 569: 100.00
+	Hs
		598473 NF1_HUMAN (408-712): 2.96e-82: 301: 23.21		KCC2G_HUMAN (1-475): 0: 617: 71.71
+	Hs
		598474 NF1_HUMAN (408-712): 2.96e-82: 301: 23.21		KCC2D_HUMAN (2-475): 0: 552: 87.55
+	Rn
		956839 NF1_RAT (408-712): 7.31e-86: 312: 25.08		CSKP_RAT (9-307): 2.45e-85: 282: 46.08
+	Hs
		598472 NF1_HUMAN (408-712): 2.96e-82: 301: 23.21		KCC2B_HUMAN (218-475): 9.21e-59: 206: 42.44