Protein: UBP20
Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)

Gene: UBP20, USP20
Organism: Homo sapiens
Interactions: 203
UniProt ID: Q9Y2K6

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356320

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

17

High-throughput

0.789

High

476599

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.755

High

310870

VAPB
Vesicle-associated membrane protein-associated protein B/C

7

6

High-throughput

0.747

High

320068

HERC2
E3 ubiquitin-protein ligase HERC2

6

15

Small-scale

0.730

High

1306423

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

5

4

High-throughput

0.720

High

1349657

VAPA
Vesicle-associated membrane protein-associated protein A

5

6

High-throughput

0.720

High

327869

CBX7
Chromobox protein homolog 7

5

7

High-throughput

0.716

High

1356041

DBNL
Drebrin-like protein

3

11

High-throughput

0.667

High

1301531

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

19

High-throughput

0.647

High

1377299

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

19

High-throughput

0.647

High

1281130

FATE1
Fetal and adult testis-expressed transcript protein

3

0

High-throughput

0.646

High

1306301

MDFI
MyoD family inhibitor

3

0

High-throughput

0.646

High

734816

TRI23
E3 ubiquitin-protein ligase TRIM23

2

7

High-throughput

0.628

High

1203594

STING
Stimulator of interferon genes protein

2

8

Small-scale

0.624

High

1377300

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.624

High

924439

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

7

Small-scale

0.618

High

1257046

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

18

Small-scale

0.618

High

1281492

FBXW7
F-box/WD repeat-containing protein 7

1

6

Small-scale

0.618

High

1377297

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

17

Small-scale

0.618

High

1222773

IHO1
Interactor of HORMAD1 protein 1

3

1

High-throughput

0.616

High

885460

VSX2
Visual system homeobox 2

3

4

High-throughput

0.609

High

876728

BRPF1
Peregrin

2

4

High-throughput

0.606

High

942583

CTG1B
Cancer/testis antigen 1

2

1

High-throughput

0.606

High

1023998

RM28
Large ribosomal subunit protein bL28m

2

1

High-throughput

0.606

High

1032282

CENPR
Centromere protein R

2

1

High-throughput

0.606

High

1148039

ZFY26
Zinc finger FYVE domain-containing protein 26

2

2

High-throughput

0.606

High

1150506

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

2

High-throughput

0.606

High

1158447

ZN343
Zinc finger protein 343

2

1

High-throughput

0.606

High

1161666

GASP3
G protein-coupled receptor associated sorting protein 3

2

2

High-throughput

0.606

High

1287759

GASP2
G-protein coupled receptor-associated sorting protein 2

2

2

High-throughput

0.606

High

1301570

TRIB3
Tribbles homolog 3

2

13

High-throughput

0.606

High

1306555

EPAS1
Endothelial PAS domain-containing protein 1

2

11

High-throughput

0.606

High

117867

MYO1C
Unconventional myosin-Ic

2

19

Small-scale

0.601

High

1295622

NEUL4
Neuralized-like protein 4

2

4

Small-scale

0.601

High

1353944

MYO1A
Unconventional myosin-Ia

2

20

Small-scale

0.601

High

1335008

CLSPN
Claspin

2

1

Small-scale

0.596

High

772211

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.586

High

279053

RAD17
Cell cycle checkpoint protein RAD17

2

4

Small-scale

0.585

High

146883

CDKA1
Cyclin-dependent kinase 2-associated protein 1

2

0

High-throughput

0.580

High

253234

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

318301

VATG2
V-type proton ATPase subunit G 2

2

0

High-throughput

0.580

High

330024

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.580

High

581216

TNNI1
Troponin I, slow skeletal muscle

2

0

High-throughput

0.580

High

1138811

IKBP1
Interleukin-1 receptor-associated kinase 1-binding protein 1

2

0

High-throughput

0.580

High

1161237

TT23L
Tetratricopeptide repeat protein 23-like

2

0

High-throughput

0.580

High

1318837

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.580

High

1327855

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

262329

ULK1
Serine/threonine-protein kinase ULK1

1

16

Small-scale

0.578

High

1301596

CRML
Protein cramped-like

2

1

High-throughput

0.574

High

1302656

MA7D2
MAP7 domain-containing protein 2

2

10

High-throughput

0.574

High

208208

SPY2
Protein sprouty homolog 2

1

2

High-throughput

0.573

High

526466

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

High-throughput

0.573

High

796360

MAGAB
Melanoma-associated antigen 11

1

1

High-throughput

0.573

High

1038339

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

13

Small-scale

0.561

High

1085553

MK06
Mitogen-activated protein kinase 6

1

9

Small-scale

0.561

High

1085729

HIF1A
Hypoxia-inducible factor 1-alpha

1

11

Small-scale

0.561

High

840640

ASCL1
Achaete-scute homolog 1

2

5

High-throughput

0.553

High

887292

MCCD1
Mitochondrial coiled-coil domain protein 1

2

1

High-throughput

0.553

High

899133

HAND2
Heart- and neural crest derivatives-expressed protein 2

2

15

High-throughput

0.553

High

957681

ZXDB
Zinc finger X-linked protein ZXDB

2

2

High-throughput

0.553

High

978252

ARI5A
AT-rich interactive domain-containing protein 5A

2

2

High-throughput

0.553

High

1100840

RSPO4
R-spondin-4

2

1

High-throughput

0.553

High

1131055

VAX1
Ventral anterior homeobox 1

2

4

High-throughput

0.553

High

1263096

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

2

High-throughput

0.553

High

1288601

ZBT10
Zinc finger and BTB domain-containing protein 10

2

1

High-throughput

0.553

High

1301926

CCNL2
Cyclin-L2

2

2

High-throughput

0.553

High

1315299

C1QT2
Complement C1q tumor necrosis factor-related protein 2

2

3

High-throughput

0.553

High

1317428

PBX4
Pre-B-cell leukemia transcription factor 4

2

3

High-throughput

0.553

High

1334233

ZN408
Zinc finger protein 408

2

1

High-throughput

0.553

High

1166739

WDR82
WD repeat-containing protein 82

1

10

Small-scale

0.553

High

1316240

DUS16
Dual specificity protein phosphatase 16

1

7

High-throughput

0.536

High

1332575

TM134
Transmembrane protein 134

1

1

High-throughput

0.536

High

429158

ADRB2
Beta-2 adrenergic receptor

2

3

Small-scale

0.533

High

1184600

BEND5
BEN domain-containing protein 5

1

1

High-throughput

0.523

High

121876

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

12

High-throughput

0.515

High

122109

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

7

High-throughput

0.515

High

267462

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.515

High

507657

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.515

High

548137

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

14

High-throughput

0.515

High

834690

NU153
Nuclear pore complex protein Nup153

1

14

High-throughput

0.515

High

849286

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

9

High-throughput

0.515

High

861994

PLK1
Serine/threonine-protein kinase PLK1

1

15

High-throughput

0.515

High

888464

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

High-throughput

0.515

High

1062901

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

11

High-throughput

0.515

High

1068706

PLEC
Plectin

1

9

High-throughput

0.515

High

1108912

MA7D1
MAP7 domain-containing protein 1

1

8

High-throughput

0.515

High

1135369

ATD3B
ATPase family AAA domain-containing protein 3B

1

10

High-throughput

0.515

High

1153467

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.515

High

1284184

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.515

High

1305037

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

2

High-throughput

0.515

High

1305519

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

2

High-throughput

0.515

High

1316169

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.515

High

1348806

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

2

High-throughput

0.515

High

46512

A0A286YEY3
SLIT-ROBO Rho GTPase activating protein 2B

1

5

High-throughput

0.515

High

537575

PA2GA
Phospholipase A2, membrane associated

1

5

Small-scale

0.501

High

568840

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

11

Small-scale

0.501

High

1245317

PJA1
E3 ubiquitin-protein ligase Praja-1

1

5

High-throughput

0.501

High

1354196

SPAST
Spastin

1

11

Small-scale

0.501

High

666360

NK3R
Neuromedin-K receptor

1

4

High-throughput

0.489

High

1330175

KCNF1
Potassium voltage-gated channel subfamily F member 1

1

2

High-throughput

0.489

High

360555

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.481

High

483674

SRG2B
SLIT-ROBO Rho GTPase-activating protein 2B

1

6

High-throughput

0.481

High

838367

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.481

High

1355512

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

1

Small-scale

0.481

High

1377298

KLH20
Kelch-like protein 20

1

8

High-throughput

0.481

High

159636

ML12B
Myosin regulatory light chain 12B

1

5

Small-scale

0.479

High

160866

AURKA
Aurora kinase A

1

20

Small-scale

0.479

High

200710

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

Small-scale

0.479

High

297432

MYO1D
Unconventional myosin-Id

1

20

Small-scale

0.479

High

326831

SNAI1
Zinc finger protein SNAI1

1

12

Small-scale

0.479

High

363954

ALBU
Albumin

1

2

Small-scale

0.479

High

396301

ARGI1
Arginase-1

1

1

Small-scale

0.479

High

396825

S10A8
Protein S100-A8

1

11

Small-scale

0.479

High

416544

S10A9
Protein S100-A9

1

12

Small-scale

0.479

High

419083

TPM3
Tropomyosin alpha-3 chain

1

3

Small-scale

0.479

High

427138

CATD
Cathepsin D

1

2

Small-scale

0.479

High

428511

TBB5
Tubulin beta chain

1

13

Small-scale

0.479

High

495638

THIO
Thioredoxin

1

1

Small-scale

0.479

High

502703

BIP
Endoplasmic reticulum chaperone BiP

1

11

Small-scale

0.479

High

519109

PIP
Prolactin-inducible protein

1

2

Small-scale

0.479

High

542484

PLAK
Junction plakoglobin

1

20

Small-scale

0.479

High

551874

DESP
Desmoplakin

1

14

Small-scale

0.479

High

642686

RL13
Large ribosomal subunit protein eL13

1

4

Small-scale

0.479

High

678529

S10A7
Protein S100-A7

1

12

Small-scale

0.479

High

686100

ARRB2
Beta-arrestin-2

1

4

Small-scale

0.479

High

717452

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

725080

MYH9
Myosin-9

1

18

Small-scale

0.479

High

725271

MYH10
Myosin-10

1

18

Small-scale

0.479

High

739355

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

Small-scale

0.479

High

751888

GRP75
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

760398

RL3
Large ribosomal subunit protein uL3

1

2

Small-scale

0.479

High

807271

RS5
Small ribosomal subunit protein uS7

1

2

Small-scale

0.479

High

807598

RS10
Small ribosomal subunit protein eS10

1

3

Small-scale

0.479

High

839242

EMD
Emerin

1

1

High-throughput

0.479

High

871839

HSP72
Heat shock-related 70 kDa protein 2

1

9

Small-scale

0.479

High

890529

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

891627

MYL6
Myosin light polypeptide 6

1

8

Small-scale

0.479

High

892131

ACTB
Actin, cytoplasmic 1

1

6

Small-scale

0.479

High

908226

RS16
Small ribosomal subunit protein uS9

1

3

Small-scale

0.479

High

910969

RS18
Small ribosomal subunit protein uS13

1

2

Small-scale

0.479

High

913846

RL7A
Large ribosomal subunit protein eL8

1

5

Small-scale

0.479

High

932926

EF1A1
Elongation factor 1-alpha 1

1

6

Small-scale

0.479

High

946629

DCD
Dermcidin

1

2

Small-scale

0.479

High

963455

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

11

Small-scale

0.479

High

970864

DSG1
Desmoglein-1

1

5

Small-scale

0.479

High

983945

KPCZ
Protein kinase C zeta type

1

10

Small-scale

0.479

High

989554

SOX4
Transcription factor SOX-4

1

8

Small-scale

0.479

High

1020995

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1037015

SQSTM
Sequestosome-1

1

11

Small-scale

0.479

High

1040306

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1045570

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

9

Small-scale

0.479

High

1087499

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.479

High

1125365

FILA2
Filaggrin-2

1

13

Small-scale

0.479

High

1140866

RN123
E3 ubiquitin-protein ligase RNF123

1

15

High-throughput

0.479

High

1175264

TBA1A
Tubulin alpha-1A chain

1

11

Small-scale

0.479

High

1206210

HORN
Hornerin

1

13

Small-scale

0.479

High

1240367

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1262633

LMO7
LIM domain only protein 7

1

9

Small-scale

0.479

High

1287948

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

1

Small-scale

0.479

High

1299109

SPB12
Serpin B12

1

4

Small-scale

0.479

High

1303643

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

1313111

DERL1
Derlin-1

1

3

High-throughput

0.479

High

1327722

SHRPN
Sharpin

1

5

Small-scale

0.479

High

1343492

XPP3
Xaa-Pro aminopeptidase 3

1

1

Small-scale

0.479

High

1346215

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.479

High

1348619

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

165790

N4BP3
NEDD4-binding protein 3

1

20

High-throughput

0.470

High

722062

RFC4
Replication factor C subunit 4

1

3

High-throughput

0.470

High

722171

RFC2
Replication factor C subunit 2

1

3

High-throughput

0.470

High

778055

RFC3
Replication factor C subunit 3

1

3

High-throughput

0.470

High

1153233

ZN770
Zinc finger protein 770

1

1

High-throughput

0.470

High

1254456

ALAT2
Alanine aminotransferase 2

1

2

High-throughput

0.470

High

1286296

SYTL4
Synaptotagmin-like protein 4

1

3

High-throughput

0.470

High

1122073

Q53XM7
VAMP

1

6

High-throughput

0.470

High

1151310

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.470

High

1310959

Q9BS75
KLHL20 protein

1

8

High-throughput

0.470

High

66321

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

345154

CYTA
Cystatin-A

1

0

Small-scale

0.458

High

994032

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

Small-scale

0.458

High

1134450

KPRP
Keratinocyte proline-rich protein

1

0

Small-scale

0.458

High

241388

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

5

Small-scale

0.437

High

344134

ANT3
Antithrombin-III

1

4

Small-scale

0.437

High

441658

ADRB1
Beta-1 adrenergic receptor

1

6

Small-scale

0.437

High

559527

H13
Histone H1.3

1

7

Small-scale

0.437

High

637095

ATPA
ATP synthase subunit alpha, mitochondrial

1

10

Small-scale

0.437

High

918167

H4
Histone H4

1

8

Small-scale

0.437

High

1038196

ATR
Serine/threonine-protein kinase ATR

1

6

Small-scale

0.437

High

1074593

CDSN
Corneodesmosin

1

1

Small-scale

0.437

High

1087139

H2A2C
Histone H2A type 2-C

1

20

Small-scale

0.437

High

1147982

Q68DG8
Uncharacterized protein DKFZp781N1423

1

4

High-throughput

0.437

High

1271288

IOD2
Type II iodothyronine deiodinase

1

1

Small-scale

0.437

High

1237285

BEND7
BEN domain-containing protein 7

3

0

High-throughput

0.352

High

1169365

ZN620
Zinc finger protein 620

2

0

High-throughput

0.316

High

1237704

SAM12
Sterile alpha motif domain-containing protein 12

2

0

High-throughput

0.316

High

275144

RENR
Renin receptor

1

0

High-throughput

0.269

Low

612077

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.269

Low

1355243

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.269

Low

629200

ZA2G
Zinc-alpha-2-glycoprotein

1

0

Small-scale

0.249

Low

887077

DEF1
Neutrophil defensin 1

1

0

Small-scale

0.249

Low

1165504

SBSN
Suprabasin

1

0

Small-scale

0.249

Low

1245494

OR1L3
Olfactory receptor 1L3

1

0

Small-scale

0.249

Low

1342281

BPIA1
BPI fold-containing family A member 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024