Protein: NLK
Serine/threonine kinase NLK (EC 2.7.11.24) (Loss of intestine protein 1) (Nemo-like kinase)

Gene: NLK, lit-1
Organism: Caenorhabditis elegans
Interactions: 62
UniProt ID: Q9U9Y8

Gene Ontology (top 5):
GO:0001714 - endodermal cell fate specification
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458190

NLK
Serine/threonine kinase NLK

3

18

Small-scale

0.840

High

760220

TRA1
Sex-determining transformer protein 1

2

2

High-throughput

0.767

High

1083921

WRM1
Armadillo repeat-containing protein wrm-1

6

7

Small-scale

0.743

High

1165073

Q17795
CRIB domain-containing protein

1

2

Small-scale

0.713

High

1083593

POP1
Protein pop-1

4

8

Small-scale

0.696

High

1169905

TRA4
Zinc finger protein tra-4

3

1

High-throughput

0.661

High

234238

CPL1
Cathepsin L-like

2

2

High-throughput

0.634

High

1166859

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

3

1

High-throughput

0.621

High

515957

ACT3
Actin-3

1

7

High-throughput

0.621

High

534411

ACT4
Actin-4

1

7

Small-scale

0.621

High

1458191

MOM4
Mitogen-activated protein kinase kinase kinase mom-4

1

20

Small-scale

0.618

High

1165783

SPE44
Transcription regulator spe-44

2

0

High-throughput

0.613

High

1019059

SPD5
Spindle-defective protein 5

2

13

High-throughput

0.594

High

1171110

TPM1
Tropomyosin isoforms a/b/d/f

2

6

High-throughput

0.576

High

759335

EMB30
Abnormal embryogenesis protein 30

2

0

High-throughput

0.551

High

1204728

NFI1
Nuclear factor I family protein

1

1

High-throughput

0.541

High

1306825

Q8ITV6
FHA domain-containing protein

1

1

High-throughput

0.541

High

1457755

Q9TYS3
Ferritin

1

1

High-throughput

0.541

High

86655

B9WRT8
C3H1-type domain-containing protein

2

2

High-throughput

0.533

High

1165206

Q17979
YDG domain-containing protein

2

1

High-throughput

0.526

High

1166615

Q19371
Protein transport protein Sec24C

2

3

High-throughput

0.526

High

1169871

BAT38
BTB and MATH domain-containing protein 38

2

6

High-throughput

0.526

High

1171190

Q23079
YDG domain-containing protein

2

1

High-throughput

0.526

High

1457753

Q9TYS1
Protein SON

2

2

High-throughput

0.526

High

1457921

Q9U290
Serine-rich adhesin for platelets

2

3

High-throughput

0.526

High

1018886

CHDP1
Calponin homology domain-containing protein

1

0

High-throughput

0.518

High

1377036

PAT12
Protein pat-12

1

0

High-throughput

0.518

High

145730

O02174
C3H1-type domain-containing protein

1

1

High-throughput

0.508

High

233258

O44490
ELKS/RAB6-interacting/CAST family member 2

1

15

High-throughput

0.494

High

145882

O02289
C3H1-type domain-containing protein

1

2

High-throughput

0.494

High

196615

O17921
Tubulin beta chain

1

8

High-throughput

0.494

High

1409456

Q9BL68
PIN domain-containing protein

1

1

High-throughput

0.494

High

1169445

Q1T6W7
PIN domain-containing protein

1

1

High-throughput

0.481

High

1457613

Q9TXM1
Uncharacterized protein

1

0

High-throughput

0.458

High

115500

H2KZI3
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

1306827

Q8ITV7
FHA domain-containing protein

1

1

High-throughput

0.457

High

1019168

P91503
HAP1 N-terminal domain-containing protein

1

12

High-throughput

0.451

High

62788

A4UVJ7
3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein

1

2

High-throughput

0.439

High

1302117

Q8I7K9
LIn-26 Related

1

2

High-throughput

0.439

High

47231

FPEB1
FLYWCH-type zinc finger-containing protein peb-1

1

0

High-throughput

0.438

High

1285985

ATF7
Transcription factor atf-7

1

0

High-throughput

0.438

High

109764

G5EBR0
LIR-1A protein

1

2

High-throughput

0.417

High

1194871

Q4JFB7
C3H1-type domain-containing protein

1

2

High-throughput

0.417

High

1458193

Q9Y050
LIR-1C protein

1

2

High-throughput

0.417

High

1170319

Q21636
GATA-type domain-containing protein

4

0

High-throughput

0.363

High

1445063

Q9N582
RanBP2-type domain-containing protein

3

0

High-throughput

0.340

High

303935

O76449
Protein F37C4.5

2

0

High-throughput

0.334

High

1457884

Q9U1S2
Bypass of Response to Pheromone in yeast

2

0

High-throughput

0.313

High

62789

A4UVJ8
SCP domain-containing protein

2

0

High-throughput

0.300

High

75825

B3WFT8
AIP3 domain-containing protein

2

0

High-throughput

0.300

High

1457911

Q9U211
EB domain-containing protein

2

0

High-throughput

0.300

High

1458192

FLH1
FLYWCH transcription factor 1

2

0

High-throughput

0.295

High

111598

G5EDA0
C2H2-type domain-containing protein

1

0

High-throughput

0.282

High

196517

O17859
Coiled-coil domain-containing protein

1

0

High-throughput

0.282

High

196733

O18098
Serpentine Receptor, class T

1

0

High-throughput

0.282

High

304085

O76621
Coiled-coil domain-containing protein 96

1

0

High-throughput

0.282

High

836462

YPT6
Uncharacterized protein F37A4.6

1

0

High-throughput

0.282

High

1164893

Q17492
F-box domain-containing protein

1

0

High-throughput

0.282

High

1165018

Q17732
SH2 domain-containing protein

1

0

High-throughput

0.282

High

1320883

Q8MPS4
Uncharacterized protein

1

0

High-throughput

0.282

High

1019433

LST1
Lateral signaling target 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025