HitPredict

Interactor 1: SYB (P18489)
Synaptobrevin
Gene: SYB

Interactor 2: Q7JYX5 (Q7JYX5)
Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1)
Gene: Vamp7

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Longin~Synaptobrevin, Synaptobrevin~Synaptobrevin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0006906 - vesicle fusion GO:0019905 - syntaxin binding GO:0031201 - SNARE complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 152 Dm			1 218
+	Hs
		907983 VAMP7_HUMAN (3-112): 4.71e-31: 112: 22.32		VAMP7_HUMAN (1-218): 9.61e-85: 252: 52.29
+	Hs
		908012 VAMP3_HUMAN (34-115): 1.55e-28: 102: 60.98		VAMP7_HUMAN (1-218): 9.61e-85: 252: 52.29
+	Dm
		121784 SYB_DROME (1-152): 1.12e-53: 168: 100.00		M9PGI6_DROME (24-206): 7.07e-57: 181: 25.54
+	Dm
		305552 SYB_DROME (1-152): 1.12e-53: 168: 100.00		O77434_DROME (24-206): 1.12e-56: 180: 25.54
+	Dm
		614978 SYB_DROME (1-152): 1.12e-53: 168: 100.00		Q9W3M8_DROME (5-179): 1.89e-50: 164: 22.16
+	Dm
		121797 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		M9PGI6_DROME (24-206): 7.07e-57: 181: 25.54
+	Dm
		305566 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		O77434_DROME (24-206): 1.12e-56: 180: 25.54
+	Dm
		1263482 Q7JYX5_DROME (4-127): 3.99e-39: 133: 14.29		Q9W3M8_DROME (5-179): 1.89e-50: 164: 22.16
+	Dm
		305601 NSYB_DROME (37-130): 1.25e-31: 113: 68.09		O77434_DROME (24-206): 1.12e-56: 180: 25.54
+	Sc
		646209 SEC22_YEAST (3-129): 6.21e-37: 127: 19.38		SEC22_YEAST (37-206): 5.35e-51: 166: 21.64
+	Sc
		646230 SEC22_YEAST (3-129): 6.21e-37: 127: 19.38		YKT6_YEAST (5-179): 1.79e-51: 166: 21.02
+	Dm
		121839 M9PGI6_DROME (3-128): 8.27e-37: 127: 16.67		Q9W3M8_DROME (5-179): 1.89e-50: 164: 22.16
+	Dm
		305604 O77434_DROME (3-128): 9.32e-37: 127: 16.67		Q9W3M8_DROME (5-179): 1.89e-50: 164: 22.16
+	Sc
		646227 SNC2_YEAST (18-115): 5.49e-29: 104: 29.59		SEC22_YEAST (37-206): 5.35e-51: 166: 21.64
+	Hs
		1154728 VAMP3_HUMAN (34-115): 1.55e-28: 102: 60.98		VAMP8_HUMAN (124-193): 2.61e-11: 60.1: 35.71
+	Hs
		989378 VAMP2_HUMAN (41-117): 5.68e-28: 101: 74.03		VAMP8_HUMAN (124-193): 2.61e-11: 60.1: 35.71