Protein: PTPS
6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) (Protein purple) (Sepiapterin synthase A)

Gene: PTPS, pr
Organism: Drosophila melanogaster
Interactions: 63
UniProt ID: P48611

Gene Ontology (top 5):
GO:0003874 - 6-pyruvoyltetrahydropterin synthase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0006728 - pteridine biosynthetic process
GO:0006729 - tetrahydrobiopterin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

875520

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

3

4

High-throughput

0.843

High

875541

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

2

1

High-throughput

0.571

High

875553

Q9VPU3
Drongo, isoform H

1

0

High-throughput

0.486

High

875523

JNK
Stress-activated protein kinase JNK

1

1

High-throughput

0.479

High

875559

PYRG
CTP synthase

1

0

High-throughput

0.458

High

875524

Q29QQ9
Ribosomal RNA-processing protein 42

1

1

High-throughput

0.445

High

68325

A8DYI2
TRPL translocation defect 14, isoform C

1

1

High-throughput

0.437

High

875535

Q9V3Q4
thioredoxin-dependent peroxiredoxin

1

1

High-throughput

0.437

High

875530

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.426

High

875533

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.426

High

875549

Q9VK19
FI07225p

1

0

High-throughput

0.426

High

875551

Q9VM14
dihydrolipoyllysine-residue acetyltransferase

1

0

High-throughput

0.426

High

875555

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.426

High

875556

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

0

High-throughput

0.426

High

875558

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.426

High

875561

SMN
Survival motor neuron protein

1

0

High-throughput

0.426

High

875562

Q9VWS1
Houki

1

0

High-throughput

0.426

High

875565

SYRC
Probable arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

875566

Q9VY76
AMP deaminase

1

0

High-throughput

0.426

High

875567

Q9VYT3
FI23714p1

1

0

High-throughput

0.426

High

875568

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.426

High

875573

SYQ
Probable glutamine--tRNA ligase

1

0

High-throughput

0.426

High

875529

TTD14
TRPL translocation defect protein 14

1

1

High-throughput

0.407

High

875539

RU2A
Probable U2 small nuclear ribonucleoprotein A'

1

1

High-throughput

0.407

High

875570

SAHH2
Adenosylhomocysteinase-like 1

2

0

High-throughput

0.298

High

838823

GRK
Protein gurken

1

0

High-throughput

0.282

High

95172

IYD
Iodotyrosine deiodinase

1

0

High-throughput

0.251

Low

714670

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.249

Low

875537

Q9V3V3
protein-tyrosine-phosphatase

1

0

High-throughput

0.249

Low

875554

BACC
Bacchus

1

0

High-throughput

0.249

Low

875557

Q9VTE7
MADF domain-containing protein

1

0

High-throughput

0.238

Low

53114

A1Z7K8
AaRS-interacting multifunctional protein 1

1

0

High-throughput

0.232

Low

56817

A1ZAK3
Protein DEK

1

0

High-throughput

0.232

Low

847852

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.232

Low

875521

MCM2
DNA replication licensing factor Mcm2

1

0

High-throughput

0.232

Low

875522

SET
Protein SET

1

0

High-throughput

0.232

Low

875525

Q494K2
Chromosome transmission fidelity 4

1

0

High-throughput

0.232

Low

875526

Q7JX41
Geminin

1

0

High-throughput

0.232

Low

875527

Q7K1Q7
Ribosome assembly factor mrt4

1

0

High-throughput

0.232

Low

875528

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.232

Low

875531

Q8SYM9
FI04119p

1

0

High-throughput

0.232

Low

875532

WDR55
WD repeat-containing protein 55 homolog

1

0

High-throughput

0.232

Low

875534

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.232

Low

875536

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

0

High-throughput

0.232

Low

875538

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.232

Low

875540

SYF2
Pre-mRNA-splicing factor Syf2

1

0

High-throughput

0.232

Low

875542

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.232

Low

875543

Q9VC93
Exosome complex exonuclease RRP44

1

0

High-throughput

0.232

Low

875544

BCCIP
Protein BCCIP homolog

1

0

High-throughput

0.232

Low

875545

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.232

Low

875546

Q9VHN4
GH14121p

1

0

High-throughput

0.232

Low

875547

Q9VHT5
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.232

Low

875548

NESD
Protein nessun dorma

1

0

High-throughput

0.232

Low

875550

Q9VKW8
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.232

Low

875552

Q9VPM0
GH06023p

1

0

High-throughput

0.232

Low

875560

Q9VUR4
FI11905p

1

0

High-throughput

0.232

Low

875563

RUXG
Probable small nuclear ribonucleoprotein G

1

0

High-throughput

0.232

Low

875564

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.232

Low

875569

THUM1
THUMP domain-containing protein 1 homolog

1

0

High-throughput

0.232

Low

875571

Q9W108
FI01540p

1

0

High-throughput

0.232

Low

875572

Q9W4J4
GM14292p

1

0

High-throughput

0.232

Low

875574

Q9Y134
RNA helicase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025