Protein: PTPRO
Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)

Gene: PTPRO
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q16827

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0002548 - monocyte chemotaxis
GO:0003093 - regulation of glomerular filtration
GO:0003105 - negative regulation of glomerular filtration
GO:0004725 - protein tyrosine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

441515

MET
Hepatocyte growth factor receptor

2

20

High-throughput

0.799

High

1087946

PTPRO
Receptor-type tyrosine-protein phosphatase O

2

16

Small-scale

0.793

High

403895

ITB1
Integrin beta-1

2

7

High-throughput

0.789

High

1031135

PTK7
Inactive tyrosine-protein kinase 7

2

20

High-throughput

0.789

High

1087998

COR1C
Coronin-1C

1

4

High-throughput

0.691

High

1087987

SDF2L
Stromal cell-derived factor 2-like protein 1

3

2

High-throughput

0.656

High

1087993

DJB11
DnaJ homolog subfamily B member 11

3

3

High-throughput

0.656

High

1088001

HYOU1
Hypoxia up-regulated protein 1

3

5

High-throughput

0.656

High

182168

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

6

High-throughput

0.647

High

383836

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

384920

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.647

High

411401

INSR
Insulin receptor

1

20

High-throughput

0.647

High

411740

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.647

High

452433

PGFRB
Platelet-derived growth factor receptor beta

1

18

High-throughput

0.647

High

581167

EPOR
Erythropoietin receptor

1

20

High-throughput

0.647

High

610425

CBL
E3 ubiquitin-protein ligase CBL

1

6

High-throughput

0.647

High

647596

MK03
Mitogen-activated protein kinase 3

1

14

High-throughput

0.647

High

782792

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.647

High

788996

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.647

High

972332

TIE2
Angiopoietin-1 receptor

1

17

High-throughput

0.647

High

160926

RAB7L
Ras-related protein Rab-7L1

1

7

High-throughput

0.618

High

161662

GAK
Cyclin-G-associated kinase

1

2

High-throughput

0.618

High

299564

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

7

High-throughput

0.618

High

382439

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.618

High

433155

LAMB1
Laminin subunit beta-1

1

7

High-throughput

0.618

High

488241

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.618

High

489969

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

16

High-throughput

0.618

High

499270

KIT
Mast/stem cell growth factor receptor Kit

1

16

Small-scale

0.618

High

502836

LAMC1
Laminin subunit gamma-1

1

7

High-throughput

0.618

High

537520

NID1
Nidogen-1

1

3

High-throughput

0.618

High

570332

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

4

High-throughput

0.618

High

665257

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.618

High

796584

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

877415

LAMB2
Laminin subunit beta-2

1

7

High-throughput

0.618

High

1087957

AN13A
Ankyrin repeat domain-containing protein 13A

1

2

High-throughput

0.618

High

1087980

RAB34
Ras-related protein Rab-34

1

5

High-throughput

0.618

High

1028053

DNJC3
DnaJ homolog subfamily C member 3

2

9

High-throughput

0.611

High

531846

PDIA4
Protein disulfide-isomerase A4

3

13

High-throughput

0.599

High

1087949

CNNM4
Metal transporter CNNM4

1

0

High-throughput

0.586

High

364293

TFR1
Transferrin receptor protein 1

2

0

High-throughput

0.585

High

423243

PDIA1
Protein disulfide-isomerase

2

13

High-throughput

0.584

High

653609

CALR
Calreticulin

2

9

High-throughput

0.584

High

654374

CALX
Calnexin

2

9

High-throughput

0.584

High

671825

PDIA3
Protein disulfide-isomerase A3

2

14

High-throughput

0.584

High

825431

LMAN1
Protein ERGIC-53

2

2

High-throughput

0.584

High

874988

TERA
Transitional endoplasmic reticulum ATPase

2

3

Small-scale

0.584

High

1058435

GANAB
Neutral alpha-glucosidase AB

2

4

High-throughput

0.584

High

1067718

PDIA6
Protein disulfide-isomerase A6

2

14

High-throughput

0.584

High

1068999

NOMO1
BOS complex subunit NOMO1

2

2

High-throughput

0.584

High

1087967

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

2

1

High-throughput

0.584

High

1087979

ERP44
Endoplasmic reticulum resident protein 44

2

14

High-throughput

0.584

High

1087990

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

2

4

High-throughput

0.584

High

1087997

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

2

1

High-throughput

0.584

High

1087960

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.559

High

1088003

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

2

0

High-throughput

0.559

High

165205

PLXB2
Plexin-B2

1

17

High-throughput

0.536

High

536373

GLU2B
Glucosidase 2 subunit beta

2

3

High-throughput

0.533

High

1034456

OS9
Protein OS-9

2

1

High-throughput

0.533

High

1087969

ERLEC
Endoplasmic reticulum lectin 1

2

1

High-throughput

0.533

High

1087974

SDF2
Stromal cell-derived factor 2

2

2

High-throughput

0.533

High

1087983

TMX1
Thioredoxin-related transmembrane protein 1

2

17

High-throughput

0.533

High

1087994

SE1L1
Protein sel-1 homolog 1

2

2

High-throughput

0.533

High

1088000

DJC16
DnaJ homolog subfamily C member 16

2

19

High-throughput

0.533

High

927094

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.508

High

1087975

SH3G1
Endophilin-A2

1

10

High-throughput

0.508

High

1087976

SH3G3
Endophilin-A3

1

8

High-throughput

0.508

High

394811

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

580238

CADH2
Cadherin-2

1

20

High-throughput

0.501

High

717127

CTNB1
Catenin beta-1

1

19

High-throughput

0.501

High

790677

WASP
Actin nucleation-promoting factor WAS

1

6

High-throughput

0.501

High

803926

NSF
Vesicle-fusing ATPase

1

9

High-throughput

0.501

High

823408

PAXI
Paxillin

1

10

High-throughput

0.501

High

121777

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

5

High-throughput

0.479

High

122030

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

6

High-throughput

0.479

High

123612

PGRC1
Membrane-associated progesterone receptor component 1

1

3

High-throughput

0.479

High

129392

GOLI4
Golgi integral membrane protein 4

1

4

High-throughput

0.479

High

234624

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

1

High-throughput

0.479

High

237064

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

3

High-throughput

0.479

High

360646

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.479

High

448974

VILI
Villin-1

1

1

Small-scale

0.479

High

502156

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

572368

LEG3
Galectin-3

1

20

High-throughput

0.479

High

572972

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.479

High

575462

EGR1
Early growth response protein 1

1

2

High-throughput

0.479

High

614337

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.479

High

762996

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.479

High

833231

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.479

High

838525

MMP14
Matrix metalloproteinase-14

1

2

High-throughput

0.479

High

972752

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

3

High-throughput

0.479

High

1027669

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.479

High

1048596

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

1071770

TMED2
Transmembrane emp24 domain-containing protein 2

1

1

High-throughput

0.479

High

1087948

P210L
Nuclear pore membrane glycoprotein 210-like

1

2

High-throughput

0.479

High

1087950

CD109
CD109 antigen

1

1

High-throughput

0.479

High

1087951

QSOX2
Sulfhydryl oxidase 2

1

14

High-throughput

0.479

High

1087952

TMTC3
Protein O-mannosyl-transferase TMTC3

1

3

High-throughput

0.479

High

1087956

DJC10
DnaJ homolog subfamily C member 10

1

19

High-throughput

0.479

High

1087961

PO210
Nuclear pore membrane glycoprotein 210

1

2

High-throughput

0.479

High

1087963

NICA
Nicastrin

1

1

High-throughput

0.479

High

1087968

ASTRA
Protein Aster-A

1

1

High-throughput

0.479

High

1087970

ERO1A
ERO1-like protein alpha

1

1

High-throughput

0.479

High

1087973

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.479

High

1087977

CAB45
45 kDa calcium-binding protein

1

1

High-throughput

0.479

High

1087985

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.479

High

1087989

DJB12
DnaJ homolog subfamily B member 12

1

5

High-throughput

0.479

High

1087996

LCAP
Leucyl-cystinyl aminopeptidase

1

1

High-throughput

0.479

High

1087999

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

2

High-throughput

0.479

High

1088002

SRPRB
Signal recognition particle receptor subunit beta

1

4

High-throughput

0.479

High

298553

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

58812

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.458

High

275017

RENR
Renin receptor

1

0

High-throughput

0.458

High

280255

CBPD
Carboxypeptidase D

1

0

High-throughput

0.458

High

295726

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.458

High

315836

AGRL2
Adhesion G protein-coupled receptor L2

1

0

High-throughput

0.458

High

390919

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

437374

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

1016588

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.458

High

1050319

MLEC
Malectin

1

0

High-throughput

0.458

High

1079816

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.458

High

1087947

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.458

High

1087955

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.458

High

1087958

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1087964

EXT2
Exostosin-2

1

0

High-throughput

0.458

High

1087965

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.458

High

1087966

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.458

High

1087988

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.458

High

1087992

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.458

High

1035378

GAB1
GRB2-associated-binding protein 1

1

5

High-throughput

0.457

High

929882

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.457

High

161074

CLGN
Calmegin

1

9

High-throughput

0.437

High

207943

XPOT
Exportin-T

1

13

High-throughput

0.437

High

776124

ARL1
ADP-ribosylation factor-like protein 1

1

4

High-throughput

0.437

High

1072681

UBE3C
Ubiquitin-protein ligase E3C

1

3

High-throughput

0.437

High

1087959

TTC13
Tetratricopeptide repeat protein 13

1

4

High-throughput

0.437

High

1087962

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.437

High

1087972

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

8

High-throughput

0.437

High

1087982

TMX4
Thioredoxin-related transmembrane protein 4

1

16

High-throughput

0.437

High

1087986

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

1

High-throughput

0.437

High

1087971

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

2

0

High-throughput

0.305

High

1087981

SIL1
Nucleotide exchange factor SIL1

2

0

High-throughput

0.305

High

1087954

YTHD3
YTH domain-containing family protein 3

1

0

High-throughput

0.279

Low

1087995

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.269

Low

147336

DPYL4
Dihydropyrimidinase-related protein 4

1

0

High-throughput

0.265

Low

1087953

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.265

Low

237663

SEP15
Selenoprotein F

1

0

High-throughput

0.249

Low

327180

TXD12
Thioredoxin domain-containing protein 12

1

0

High-throughput

0.249

Low

891405

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.249

Low

894856

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.249

Low

1062952

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.249

Low

1087978

PGAP4
Post-GPI attachment to proteins factor 4

1

0

High-throughput

0.249

Low

1087984

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

1087991

CNIH4
Protein cornichon homolog 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024