Protein: NPHP4
Nephrocystin-4 (Nephroretinin)

Gene: NPHP4
Organism: Mus musculus
Interactions: 207
UniProt ID: P59240

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005814 - centriole
GO:0005829 - cytosol
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

947788

NPHP1
Nephrocystin-1

1

4

High-throughput

0.590

High

947743

FTM
Protein fantom

1

7

High-throughput

0.586

High

462105

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.536

High

602285

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.536

High

947731

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

947725

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.493

High

947797

Q9Z1R9
trypsin

1

3

High-throughput

0.489

High

59536

CNTRL
Centriolin

1

5

High-throughput

0.479

High

98049

DESP
Desmoplakin

1

4

High-throughput

0.479

High

98430

E9QQ96
non-specific serine/threonine protein kinase

1

1

High-throughput

0.479

High

385197

K1C10
Keratin, type I cytoskeletal 10

1

17

High-throughput

0.479

High

399478

GFAP
Glial fibrillary acidic protein

1

15

High-throughput

0.479

High

403094

K2C1
Keratin, type II cytoskeletal 1

1

13

High-throughput

0.479

High

426888

TBA1B
Tubulin alpha-1B chain

1

6

High-throughput

0.479

High

456908

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

465810

ENPL
Endoplasmin

1

4

High-throughput

0.479

High

518544

ANXA1
Annexin A1

1

1

High-throughput

0.479

High

547241

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

547941

K2C8
Keratin, type II cytoskeletal 8

1

11

High-throughput

0.479

High

572877

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.479

High

627461

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

628488

VIME
Vimentin

1

14

High-throughput

0.479

High

663469

CRYAB
Alpha-crystallin B chain

1

1

High-throughput

0.479

High

801609

HSPA9
Stress-70 protein, mitochondrial

1

7

High-throughput

0.479

High

947651

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.479

High

947652

ACTA
Actin, aortic smooth muscle

1

3

High-throughput

0.479

High

947654

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.479

High

947655

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

947657

ACTG
Actin, cytoplasmic 2

1

3

High-throughput

0.479

High

947659

TBA4A
Tubulin alpha-4A chain

1

5

High-throughput

0.479

High

947660

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.479

High

947661

TBB4B
Tubulin beta-4B chain

1

7

High-throughput

0.479

High

947665

PKP1
Plakophilin-1

1

1

High-throughput

0.479

High

947667

TBB5
Tubulin beta-5 chain

1

7

High-throughput

0.479

High

947674

K22E
Keratin, type II cytoskeletal 2 epidermal

1

11

High-throughput

0.479

High

947688

SRC8
Src substrate cortactin

1

1

High-throughput

0.479

High

947693

DSG1A
Desmoglein-1-alpha

1

1

High-throughput

0.479

High

947694

K1C14
Keratin, type I cytoskeletal 14

1

14

High-throughput

0.479

High

947695

MYH10
Myosin-10

1

1

High-throughput

0.479

High

947698

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

3

High-throughput

0.479

High

947702

K1C42
Keratin, type I cytoskeletal 42

1

16

High-throughput

0.479

High

947710

FHOD1
FH1/FH2 domain-containing protein 1

1

1

High-throughput

0.479

High

947715

TBB2A
Tubulin beta-2A chain

1

7

High-throughput

0.479

High

947720

FLNB
Filamin-B

1

4

High-throughput

0.479

High

947727

FLNA
Filamin-A

1

4

High-throughput

0.479

High

947732

VP13C
Intermembrane lipid transfer protein VPS13C

1

1

High-throughput

0.479

High

947740

FEM1C
Protein fem-1 homolog C

1

2

High-throughput

0.479

High

947750

EPIPL
Epiplakin

1

2

High-throughput

0.479

High

947753

MYH9
Myosin-9

1

1

High-throughput

0.479

High

947755

FLNC
Filamin-C

1

4

High-throughput

0.479

High

947760

SMTN
Smoothelin

1

3

High-throughput

0.479

High

947761

TBB6
Tubulin beta-6 chain

1

7

High-throughput

0.479

High

947763

K2C5
Keratin, type II cytoskeletal 5

1

12

High-throughput

0.479

High

947771

K1C20
Keratin, type I cytoskeletal 20

1

17

High-throughput

0.479

High

947772

TSSK4
Testis-specific serine/threonine-protein kinase 4

1

1

High-throughput

0.479

High

947777

K2C7
Keratin, type II cytoskeletal 7

1

11

High-throughput

0.479

High

947778

TBB3
Tubulin beta-3 chain

1

7

High-throughput

0.479

High

947785

K1C17
Keratin, type I cytoskeletal 17

1

16

High-throughput

0.479

High

947786

PLEC
Plectin

1

5

High-throughput

0.479

High

947790

RPGR
X-linked retinitis pigmentosa GTPase regulator

1

2

Small-scale

0.479

High

947791

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.479

High

61343

RGPA2
Ral GTPase-activating protein subunit alpha-2

1

0

High-throughput

0.458

High

62340

GL1D1
Glycosyltransferase 1 domain-containing protein 1

1

0

High-throughput

0.458

High

64306

SAC31
SAC3 domain-containing protein 1

1

0

High-throughput

0.458

High

148424

PKD1
Polycystin-1

1

0

High-throughput

0.458

High

205694

PITM1
Membrane-associated phosphatidylinositol transfer protein 1

1

0

High-throughput

0.458

High

312062

O88325
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.458

High

508934

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

559564

GELS
Gelsolin

1

0

High-throughput

0.458

High

580356

CADH2
Cadherin-2

1

0

High-throughput

0.458

High

701624

ACOHC
Cytoplasmic aconitate hydratase

1

0

High-throughput

0.458

High

771734

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.458

High

776003

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.458

High

832284

ID3
DNA-binding protein inhibitor ID-3

1

0

High-throughput

0.458

High

893272

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.458

High

944876

PCBP3
Poly(rC)-binding protein 3

1

0

High-throughput

0.458

High

947650

MRTFB
Myocardin-related transcription factor B

1

0

High-throughput

0.458

High

947656

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

947663

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.458

High

947664

DAB1
Disabled homolog 1

1

0

High-throughput

0.458

High

947668

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

0

High-throughput

0.458

High

947669

PLAK
Junction plakoglobin

1

0

High-throughput

0.458

High

947670

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.458

High

947682

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.458

High

947685

AN13B
Ankyrin repeat domain-containing protein 13B

1

0

High-throughput

0.458

High

947689

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

947691

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

947707

SIK3
Serine/threonine-protein kinase SIK3

1

0

High-throughput

0.458

High

947708

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.458

High

947711

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

947714

ERI1
3'-5' exoribonuclease 1

1

0

High-throughput

0.458

High

947724

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.458

High

947734

RBM4
RNA-binding protein 4

1

0

High-throughput

0.458

High

947738

FXL13
F-box and leucine-rich repeat protein 13

1

0

High-throughput

0.458

High

947739

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.458

High

947752

EMAL3
Echinoderm microtubule-associated protein-like 3

1

0

High-throughput

0.458

High

947756

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.458

High

947757

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

947762

KIF2C
Kinesin-like protein KIF2C

1

0

High-throughput

0.458

High

947764

MYO5A
Unconventional myosin-Va

1

0

High-throughput

0.458

High

947768

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

947773

SPB7
Serpin B7

1

0

High-throughput

0.458

High

947775

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.458

High

947779

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

947780

GSDMA
Gasdermin-A

1

0

High-throughput

0.458

High

947781

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.458

High

947782

PAR6G
Partitioning defective 6 homolog gamma

1

0

High-throughput

0.458

High

947787

DREB
Drebrin

1

0

High-throughput

0.458

High

947789

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

High-throughput

0.458

High

947793

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.458

High

947795

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.458

High

947799

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

59722

A2APS1
Nephrocystin-1

1

4

High-throughput

0.445

High

947719

SPAT7
Spermatogenesis-associated protein 7 homolog

1

1

Small-scale

0.445

High

67204

A6PWA5
PRAME like 25

1

1

High-throughput

0.437

High

73008

B1ART2
Vacuolar protein sorting 13D

1

1

High-throughput

0.437

High

73009

B1ARV6
PRAME like 15

1

1

High-throughput

0.437

High

86339

B9EKJ1
Spectrin alpha chain, non-erythrocytic 1

1

4

High-throughput

0.437

High

98278

E9QAH1
Golgin B1

1

4

High-throughput

0.437

High

205635

CALU
Calumenin

1

2

High-throughput

0.437

High

470794

NFM
Neurofilament medium polypeptide

1

15

High-throughput

0.437

High

475787

K1C13
Keratin, type I cytoskeletal 13

1

17

High-throughput

0.437

High

895417

K2C6A
Keratin, type II cytoskeletal 6A

1

12

High-throughput

0.437

High

947658

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.437

High

947666

KRT86
Keratin, type II cuticular Hb6

1

10

High-throughput

0.437

High

947671

DNAL1
Dynein axonemal light chain 1

1

1

High-throughput

0.437

High

947675

YETS2
YEATS domain-containing protein 2

1

2

High-throughput

0.437

High

947678

K22O
Keratin, type II cytoskeletal 2 oral

1

14

High-throughput

0.437

High

947681

KRT35
Keratin, type I cuticular Ha5

1

16

High-throughput

0.437

High

947687

MYPC2
Myosin-binding protein C, fast-type

1

2

High-throughput

0.437

High

947690

CAB45
45 kDa calcium-binding protein

1

2

High-throughput

0.437

High

947692

K1C15
Keratin, type I cytoskeletal 15

1

17

High-throughput

0.437

High

947696

KT33B
Keratin, type I cuticular Ha3-II

1

16

High-throughput

0.437

High

947701

Q6IFT3
Keratin Kb40

1

12

High-throughput

0.437

High

947703

K2C1B
Keratin, type II cytoskeletal 1b

1

12

High-throughput

0.437

High

947705

K2C73
Keratin, type II cytoskeletal 73

1

13

High-throughput

0.437

High

947713

Q792Z1
trypsin

1

3

High-throughput

0.437

High

947716

ACTN1
Alpha-actinin-1

1

1

High-throughput

0.437

High

947718

NAV3
Neuron navigator 3

1

6

High-throughput

0.437

High

947726

RCN2
Reticulocalbin-2

1

2

High-throughput

0.437

High

947729

Q8BUJ0
Titin

1

2

High-throughput

0.437

High

947733

Q8BXZ6
Uncharacterized protein

1

1

High-throughput

0.437

High

947736

TTC27
Tetratricopeptide repeat protein 27

1

1

High-throughput

0.437

High

947737

CALI
Calicin

1

1

High-throughput

0.437

High

947744

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

3

High-throughput

0.437

High

947745

EP400
E1A-binding protein p400

1

1

High-throughput

0.437

High

947748

ABC8B
ABC-type organic anion transporter ABCA8B

1

1

High-throughput

0.437

High

947749

ABC8A
ABC-type organic anion transporter ABCA8A

1

1

High-throughput

0.437

High

947754

K2C79
Keratin, type II cytoskeletal 79

1

13

High-throughput

0.437

High

947758

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.437

High

947765

KRT82
Keratin, type II cuticular Hb2

1

10

High-throughput

0.437

High

947766

Q9CPN9
trypsin

1

3

High-throughput

0.437

High

947767

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.437

High

947783

TRY5
Trypsin-5

1

3

High-throughput

0.437

High

947784

FAK2
Protein-tyrosine kinase 2-beta

1

1

Small-scale

0.437

High

947798

K1C16
Keratin, type I cytoskeletal 16

1

16

High-throughput

0.437

High

947649

NPHP4
Nephrocystin-4

1

0

High-throughput

0.426

High

59235

MED14
Mediator of RNA polymerase II transcription subunit 14

1

0

High-throughput

0.249

Low

85510

B7ZNL9
TatD DNase domain containing 2

1

0

High-throughput

0.249

Low

92708

D3Z3J7
RNA exonuclease 5

1

0

High-throughput

0.249

Low

92759

D3Z4Z0
Transcriptional adapter

1

0

High-throughput

0.249

Low

97702

E9PWB6
Mucin-2

1

0

High-throughput

0.249

Low

198264

O19442
Histocompatibility 2, M region locus 9

1

0

High-throughput

0.249

Low

204796

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.249

Low

312055

NID2
Nidogen-2

1

0

High-throughput

0.249

Low

633590

HXB9
Homeobox protein Hox-B9

1

0

High-throughput

0.249

Low

686764

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.249

Low

704312

SNAB
Beta-soluble NSF attachment protein

1

0

High-throughput

0.249

Low

947653

HPCL1
Hippocalcin-like protein 1

1

0

High-throughput

0.249

Low

947662

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

0

High-throughput

0.249

Low

947672

CDK12
Cyclin-dependent kinase 12

1

0

High-throughput

0.249

Low

947673

ML12B
Myosin regulatory light chain 12B

1

0

High-throughput

0.249

Low

947676

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.249

Low

947677

PROM2
Prominin-2

1

0

High-throughput

0.249

Low

947679

GUC2C
Guanylyl cyclase C

1

0

High-throughput

0.249

Low

947680

Q3UX37
Pleckstrin homology domain containing, family G

1

0

High-throughput

0.249

Low

947683

TR150
Thyroid hormone receptor-associated protein 3

1

0

High-throughput

0.249

Low

947684

LIN54
Protein lin-54 homolog

1

0

High-throughput

0.249

Low

947686

NOL10
Nucleolar protein 10

1

0

High-throughput

0.249

Low

947697

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.249

Low

947699

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

947700

EX3L4
Exocyst complex component 3-like protein 4

1

0

High-throughput

0.249

Low

947704

Q6IMH7
A disintegrin and metallopeptidase domain 6B

1

0

High-throughput

0.249

Low

947706

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.249

Low

947709

Q6P9L5
Nup205 protein

1

0

High-throughput

0.249

Low

947712

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.249

Low

947717

ZSWM5
Zinc finger SWIM domain-containing protein 5

1

0

High-throughput

0.249

Low

947721

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

0

High-throughput

0.249

Low

947722

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.249

Low

947723

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.249

Low

947728

Q8BU90
Olfactomedin 5

1

0

High-throughput

0.249

Low

947730

Q8BUX1
BTB domain-containing protein

1

0

High-throughput

0.249

Low

947735

F161B
Protein FAM161B

1

0

High-throughput

0.249

Low

947741

Q8CEW7
Uncharacterized protein

1

0

High-throughput

0.249

Low

947742

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.249

Low

947746

SAYS1
SAYSvFN domain-containing protein 1

1

0

High-throughput

0.249

Low

947747

FRRS1
Ferric-chelate reductase 1

1

0

High-throughput

0.249

Low

947751

ANGL6
Angiopoietin-related protein 6

1

0

High-throughput

0.249

Low

947759

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.249

Low

947769

ZDH13
Palmitoyltransferase ZDHHC13

1

0

High-throughput

0.249

Low

947770

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

947774

Q9DAN0
IQ domain-containing protein M

1

0

High-throughput

0.249

Low

947776

CALY
Neuron-specific vesicular protein calcyon

1

0

High-throughput

0.249

Low

947792

CCR9
C-C chemokine receptor type 9

1

0

High-throughput

0.249

Low

947794

OSR1
Protein odd-skipped-related 1

1

0

High-throughput

0.249

Low

947796

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025