Protein: TIMP3
Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)

Gene: TIMP3
Organism: Homo sapiens
Interactions: 89
UniProt ID: P35625

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005576 - extracellular region
GO:0005604 - basement membrane
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439230

MMP2
72 kDa type IV collagenase

3

20

Small-scale

0.866

High

439265

MMP3
Stromelysin-1

2

20

High-throughput

0.789

High

726505

MMP14
Matrix metalloproteinase-14

1

20

High-throughput

0.691

High

554805

TIMP2
Metalloproteinase inhibitor 2

3

1

High-throughput

0.667

High

726508

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

3

5

Small-scale

0.660

High

526646

GILT
Gamma-interferon-inducible lysosomal thiol reductase

3

0

High-throughput

0.638

High

726529

NELL1
Protein kinase C-binding protein NELL1

2

4

High-throughput

0.628

High

726539

COL11
Collectin-11

2

3

High-throughput

0.611

High

726556

COL10
Collectin-10

2

4

High-throughput

0.611

High

362370

CRP

2

0

High-throughput

0.602

High

394225

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.602

High

726502

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

2

0

High-throughput

0.602

High

726537

ADPGK
ADP-dependent glucokinase

2

0

High-throughput

0.602

High

59735

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

1

High-throughput

0.574

High

273382

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.536

High

351055

LDLR
Low-density lipoprotein receptor

1

4

High-throughput

0.536

High

445154

IBP1
Insulin-like growth factor-binding protein 1

1

1

High-throughput

0.536

High

445250

CEL3B
Chymotrypsin-like elastase family member 3B

1

1

High-throughput

0.536

High

486233

CCL3
C-C motif chemokine 3

1

1

High-throughput

0.536

High

557052

PGFRA
Platelet-derived growth factor receptor alpha

1

4

High-throughput

0.536

High

561729

CL3L1
C-C motif chemokine 3-like 1

1

1

High-throughput

0.536

High

609650

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

1

High-throughput

0.536

High

610688

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

1

High-throughput

0.536

High

726501

PPM1A
Protein phosphatase 1A

1

1

High-throughput

0.536

High

726506

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

726507

DEF1
Neutrophil defensin 1

1

1

High-throughput

0.536

High

726512

DEF5
Defensin alpha 5

1

1

High-throughput

0.536

High

726521

FREM2
FRAS1-related extracellular matrix protein 2

1

2

High-throughput

0.536

High

726525

FRAS1
Extracellular matrix organizing protein FRAS1

1

5

High-throughput

0.536

High

726528

SORL
Sortilin-related receptor

1

4

High-throughput

0.536

High

726533

VWCE
von Willebrand factor C and EGF domain-containing protein

1

3

High-throughput

0.536

High

726536

WFDC6
WAP four-disulfide core domain protein 6

1

1

High-throughput

0.536

High

726540

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

1

High-throughput

0.536

High

726553

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

2

High-throughput

0.536

High

726555

ST14
Suppressor of tumorigenicity 14 protein

1

2

High-throughput

0.536

High

181684

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

0

High-throughput

0.513

High

231285

GANP
Germinal-center associated nuclear protein

1

0

High-throughput

0.513

High

295849

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.513

High

389444

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.513

High

423163

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.513

High

435943

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

517928

CO6A1

1

0

High-throughput

0.513

High

726513

NOTC2
Neurogenic locus notch homolog protein 2

1

0

High-throughput

0.513

High

726514

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.513

High

726515

SG2A2
Mammaglobin-A

1

0

High-throughput

0.513

High

726534

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.513

High

726535

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

726538

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.513

High

726544

CAD23
Cadherin-23

1

0

High-throughput

0.513

High

726549

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.513

High

257256

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

3

Small-scale

0.501

High

726554

ATS5
A disintegrin and metalloproteinase with thrombospondin motifs 5

1

3

Small-scale

0.501

High

195688

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

1

High-throughput

0.489

High

258297

LRP5
Low-density lipoprotein receptor-related protein 5

1

4

High-throughput

0.489

High

409500

HEPS
Serine protease hepsin

1

2

High-throughput

0.489

High

726509

IDD
Integral membrane protein DGCR2/IDD

1

6

High-throughput

0.489

High

726510

LRP2
Low-density lipoprotein receptor-related protein 2

1

4

High-throughput

0.489

High

726522

HECD3
E3 ubiquitin-protein ligase HECTD3

1

1

High-throughput

0.489

High

726524

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

6

High-throughput

0.489

High

726531

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.489

High

726542

TMPSD
Transmembrane protease serine 13

1

2

High-throughput

0.489

High

726543

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.489

High

726545

TOR3A
Torsin-3A

1

1

High-throughput

0.489

High

726548

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

5

High-throughput

0.489

High

726550

SE1L1
Protein sel-1 homolog 1

1

8

High-throughput

0.489

High

346093

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

379072

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

726516

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

5

Small-scale

0.479

High

443369

VIME
Vimentin

1

1

High-throughput

0.470

High

726517

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

726530

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

726551

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

726518

NTRK3
NT-3 growth factor receptor

1

3

High-throughput

0.457

High

401526

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

426816

ASGR2
Asialoglycoprotein receptor 2

3

0

High-throughput

0.347

High

726504

AGTR2
Type-2 angiotensin II receptor

1

0

Small-scale

0.305

High

679209

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.279

Low

726503

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.279

Low

726511

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.279

Low

726520

FUT11
Alpha-(1,3)-fucosyltransferase 11

1

0

High-throughput

0.279

Low

726523

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.279

Low

726526

STK40
Serine/threonine-protein kinase 40

1

0

High-throughput

0.279

Low

726527

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

726532

F136A
Protein FAM136A

1

0

High-throughput

0.279

Low

726541

TMM59
Transmembrane protein 59

1

0

High-throughput

0.279

Low

726552

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.279

Low

726519

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

726546

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

726547

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024