Protein: TREX1
Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (Deoxyribonuclease III) (DNase III)

Gene: TREX1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q9NSU2

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001568 - blood vessel development
GO:0001822 - kidney development
GO:0002253 - activation of immune response
GO:0002281 - macrophage activation involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

950417

KR107
Keratin-associated protein 10-7

2

0

High-throughput

0.626

High

977839

ACTA
Actin, aortic smooth muscle

2

0

High-throughput

0.602

High

1449455

RAB23
Ras-related protein Rab-23

2

0

High-throughput

0.602

High

142114

PEX12
Peroxisome assembly protein 12

2

0

High-throughput

0.580

High

800321

INGR2
Interferon gamma receptor 2

2

0

High-throughput

0.580

High

883443

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.580

High

948942

CD81
CD81 antigen

2

0

High-throughput

0.580

High

1142951

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1279376

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

1328207

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1328812

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.580

High

1348647

S7A14
Solute carrier family 7 member 14

2

0

High-throughput

0.580

High

1417779

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

0

High-throughput

0.580

High

1428514

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.580

High

1449458

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

1029393

SET
Protein SET

1

0

Small-scale

0.561

High

166092

FFAR3
Free fatty acid receptor 3

2

2

High-throughput

0.553

High

1449456

UBQL1
Ubiquilin-1

1

0

Small-scale

0.537

High

683657

ITB8
Integrin beta-8

1

0

High-throughput

0.513

High

1360757

JPH3
Junctophilin-3

1

0

High-throughput

0.493

High

193458

GPR42
G-protein coupled receptor 42

1

2

High-throughput

0.470

High

1313708

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.460

High

1410465

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

1449457

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.460

High

417790

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

573896

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

1255728

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

70500

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

783024

CXA5
Gap junction alpha-5 protein

2

0

High-throughput

0.316

High

1109064

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1186053

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.316

High

1210316

MF14B
Hippocampus abundant transcript-like protein 1

2

0

High-throughput

0.316

High

1242818

RNK
Ribonuclease kappa

2

0

High-throughput

0.316

High

1248360

TM205
Transmembrane protein 205

2

0

High-throughput

0.316

High

1248904

TM207
Transmembrane protein 207

2

0

High-throughput

0.316

High

1308009

RELL1
RELT-like protein 1

2

0

High-throughput

0.316

High

1330620

CLD22
Claudin-22

2

0

High-throughput

0.316

High

1348792

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.316

High

1349126

F174A
Membrane protein FAM174A

2

0

High-throughput

0.316

High

1383965

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.316

High

1385810

T4S18
Transmembrane 4 L6 family member 18

2

0

High-throughput

0.316

High

1414230

CRUM3
Protein crumbs homolog 3

2

0

High-throughput

0.316

High

1449141

GKN1
Gastrokine-1

2

0

High-throughput

0.316

High

1449454

PRND
Prion-like protein doppel

2

0

High-throughput

0.316

High

1399688

FCRL4
Fc receptor-like protein 4

1

0

High-throughput

0.279

Low

183976

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.251

Low

1207634

F209A
Protein FAM209A

1

0

High-throughput

0.251

Low

1433715

RIBC2
RIB43A-like with coiled-coils protein 2

1

0

High-throughput

0.251

Low

1449459

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.251

Low

980407

H4
Histone H4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025