Protein: EYA1
Protein phosphatase eya-1 (EC 3.1.3.48) (Eyes absent homolog 1)

Gene: EYA1, eya-1
Organism: Caenorhabditis elegans
Interactions: 153
UniProt ID: O17670

Gene Ontology (top 5):
GO:0002119 - nematode larval development
GO:0003713 - transcription coactivator activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

196356

HM34
Homeobox protein ceh-34

4

20

Small-scale

0.695

High

196276

HM35
Homeobox protein unc-39

3

20

High-throughput

0.677

High

196305

POP1
Protein pop-1

3

9

High-throughput

0.677

High

196387

PICAL
Phosphatidylinositol-binding clathrin assembly protein unc-11

2

1

High-throughput

0.654

High

196357

HM33
Homeobox protein ceh-33

2

20

High-throughput

0.620

High

116566

H8ESF3
SWI/SNF complex subunit SMARCC2

2

5

High-throughput

0.595

High

196293

FOZI1
Formin-homology and zinc finger domains protein 1

2

0

High-throughput

0.594

High

196330

MEGG2
Protein meg-2

2

1

High-throughput

0.584

High

196367

Q9N4P3
R3H domain-containing protein

2

3

High-throughput

0.584

High

92564

D3YT85
DM domain-containing protein

2

1

High-throughput

0.584

High

196358

Q95QZ3
NOT2/NOT3/NOT5 C-terminal domain-containing protein

2

3

High-throughput

0.584

High

196289

ABL1
Tyrosine-protein kinase abl-1

1

3

High-throughput

0.560

High

196306

Q10923
NOT2/NOT3/NOT5 C-terminal domain-containing protein

2

3

High-throughput

0.544

High

110858

G5ECJ4
Mec-8 protein

1

3

High-throughput

0.541

High

114009

TAF1
Transcription initiation factor TFIID subunit 1

1

7

High-throughput

0.541

High

115752

H2L031
NOT2/NOT3/NOT5 C-terminal domain-containing protein

1

4

High-throughput

0.541

High

196277

O44447
SH3 domain-containing protein

1

9

High-throughput

0.541

High

196290

MAB5
Homeobox protein mab-5

1

4

High-throughput

0.541

High

196291

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.541

High

196296

CLP1
Protein clpf-1

1

2

High-throughput

0.541

High

196299

EGL27
Egg-laying defective protein 27

1

5

High-throughput

0.541

High

196304

FOX1
Sex determination protein fox-1

1

4

High-throughput

0.541

High

196315

Q18241
Helicase ARIP4

1

9

High-throughput

0.541

High

196331

NFIL3
Transcription factor atf-2

1

4

High-throughput

0.541

High

196368

NHR13
Nuclear hormone receptor family member nhr-13

1

8

High-throughput

0.541

High

196377

TFG
Protein tfg-1

1

8

High-throughput

0.541

High

113174

SEM4
Spalt-like protein sem-4

1

0

High-throughput

0.518

High

196283

PQN59
Prion-like

1

0

High-throughput

0.518

High

196288

O62332
Importin N-terminal domain-containing protein

1

0

High-throughput

0.518

High

196300

LAG3
Protein lag-3

1

0

High-throughput

0.518

High

196321

Q19007
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.518

High

196326

Q20956
Spt4 domain-containing protein

1

0

High-throughput

0.518

High

196359

GLD3
Defective in germ line development protein 3

1

0

High-throughput

0.518

High

196382

Q9XV36
Phospholipid scramblase

1

1

High-throughput

0.512

High

63457

SIN3
Paired amphipathic helix protein sin-3

1

1

High-throughput

0.508

High

110838

FOS1
Transcription factor fos-1

1

1

High-throughput

0.508

High

111453

PAX3H
Paired box protein 3 homolog

1

5

High-throughput

0.508

High

146019

UNC37
Transcription factor unc-37

1

7

High-throughput

0.508

High

195242

O16213
BZIP domain-containing protein

1

6

High-throughput

0.508

High

196279

NH111
Nuclear hormone receptor family member nhr-111

1

7

High-throughput

0.508

High

196280

NHR49
Nuclear hormone receptor family member nhr-49

1

6

High-throughput

0.508

High

196281

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.508

High

196287

KLF2
Kruppel-like factor 2

1

2

High-throughput

0.508

High

196294

WBS14
Protein WBSCR14 homolog

1

8

High-throughput

0.508

High

196297

UNC30
Homeobox protein unc-30

1

3

High-throughput

0.508

High

196302

NHR22
Nuclear hormone receptor family member nhr-22

1

10

High-throughput

0.508

High

196307

FKH6
Forkhead transcription factor fkh-6

1

3

High-throughput

0.508

High

196309

PHA4
Defective pharyngeal development protein 4

1

1

High-throughput

0.508

High

196316

NHR43
Nuclear hormone receptor family member nhr-43

1

6

High-throughput

0.508

High

196318

UN130
Forkhead box protein unc-130

1

1

High-throughput

0.508

High

196332

Q21372
Nuclear Hormone Receptor family

1

5

High-throughput

0.508

High

196335

Q22805
C3H1-type domain-containing protein

1

3

High-throughput

0.508

High

196337

HM30
Homeobox protein ceh-30

1

5

High-throughput

0.508

High

196338

EGL13
Transcription factor egl-13

1

9

High-throughput

0.508

High

196363

Q9N2W3
Nuclear receptor

1

10

High-throughput

0.508

High

196370

ODD2
Protein odd-skipped-related 2

1

1

High-throughput

0.508

High

196371

TBX39
Putative T-box protein 39

1

1

High-throughput

0.508

High

196374

Q9TXN8
DM domain-containing protein

1

1

High-throughput

0.508

High

196375

CEH51
Homeobox protein ceh-51

1

5

High-throughput

0.508

High

196384

Q9XVN4
Homeobox domain-containing protein

1

8

High-throughput

0.508

High

196385

NHR67
Nuclear hormone receptor family member nhr-67

1

7

High-throughput

0.508

High

110142

G5EBV4
Galectin

1

1

High-throughput

0.494

High

113600

G5EFY6
WD_REPEATS_REGION domain-containing protein

1

2

High-throughput

0.494

High

113840

G5EGG0
Uso1_p115_head domain-containing protein

1

1

High-throughput

0.494

High

196282

RLE1
Regulation of longevity by E3 ubiquitin-protein ligase

1

1

High-throughput

0.494

High

196301

GUAA
Probable GMP synthase [glutamine-hydrolyzing]

1

1

High-throughput

0.494

High

196329

MEGG1
Protein meg-1

1

1

High-throughput

0.494

High

196347

Q86G90
Nuclear Pore complex Protein

1

2

High-throughput

0.494

High

196350

Q8MQ25
C2H2-type domain-containing protein

1

1

High-throughput

0.494

High

196355

Q93619
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

1

High-throughput

0.494

High

196360

Q9BIC1
Afadin

1

5

High-throughput

0.494

High

196362

Q9GYQ9
CCR4-NOT transcription complex subunit 4

1

1

High-throughput

0.494

High

196373

Q9NAE9
Phospholipid scramblase

1

1

High-throughput

0.494

High

196320

Q18999
Putative RNA-binding protein PTB-1a

1

3

High-throughput

0.494

High

112000

G5EDU4
EOR-1

1

0

High-throughput

0.486

High

196295

SMA4
Dwarfin sma-4

1

0

High-throughput

0.486

High

196314

SPE44
Transcription regulator spe-44

1

0

High-throughput

0.486

High

196334

TBX9
T-box transcription factor tbx-9

1

0

High-throughput

0.486

High

196336

Q22826
Fork-head domain-containing protein

1

0

High-throughput

0.486

High

196381

ZIP3
Transcription factor zip-3

1

0

High-throughput

0.486

High

94703

E0AHC2
ETS domain-containing protein

1

3

High-throughput

0.481

High

115122

HAM2
Zinc finger protein ham-2

1

1

High-throughput

0.481

High

115603

H2KZU3
NR LBD domain-containing protein

1

11

High-throughput

0.481

High

145678

O02174
C3H1-type domain-containing protein

1

1

High-throughput

0.481

High

196348

Q86G94
RRM domain-containing protein

1

3

High-throughput

0.481

High

196349

Q86PI8
Nuclear receptor NHR-114

1

11

High-throughput

0.481

High

196352

Q8T3E6
Putative RNA-binding protein PTB-1b

1

2

High-throughput

0.481

High

196353

Q93156
BED-type domain-containing protein

1

5

High-throughput

0.481

High

196317

Q18477
Histone deacetylase 11

1

2

High-throughput

0.464

High

196322

ZTF2
Zinc finger protein ztf-2

1

1

High-throughput

0.464

High

196324

Q19760
JmjC domain-containing protein

1

2

High-throughput

0.464

High

196339

MOE2
CCCH-type zinc finger protein oma-2

1

1

High-throughput

0.464

High

196344

NU301
Nucleosome-remodeling factor subunit NURF301-like

1

10

High-throughput

0.464

High

196372

Q9NAE4
BZIP domain-containing protein

1

7

High-throughput

0.464

High

196378

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.464

High

196383

MOE3
CCCH-type zinc finger protein moe-3

1

2

High-throughput

0.464

High

92412

D3NQC0
C2H2-type domain-containing protein

1

0

High-throughput

0.460

High

63374

EFL2
Transcription factor efl-2

1

2

High-throughput

0.457

High

110631

G5EC57
Ets-domain protein

1

3

High-throughput

0.457

High

111884

VAB3
Paired box protein 6 homolog

1

3

High-throughput

0.457

High

112608

NH114
Nuclear hormone receptor 114

1

9

High-throughput

0.457

High

112857

G5EEW7
RNA-binding protein ASD-1

1

3

High-throughput

0.457

High

113016

G5EF87
SWI/SNF complex subunit SMARCC2

1

9

High-throughput

0.457

High

113149

ASD2
RNA-binding protein asd-2

1

4

High-throughput

0.457

High

115509

H2KZI6
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

115626

H2KZU4
NR LBD domain-containing protein

1

7

High-throughput

0.457

High

115700

ZTF16
Zinc finger protein ztf-16

1

3

High-throughput

0.457

High

117750

UNC42
Homeobox protein unc-42

1

2

High-throughput

0.457

High

196284

ELT7
Transcription factor elt-7

1

2

High-throughput

0.457

High

196286

O62159
DM domain-containing protein

1

1

High-throughput

0.457

High

196340

Q27420
NOT2/NOT3/NOT5 C-terminal domain-containing protein

1

3

High-throughput

0.457

High

196341

EHN3
Zinc finger protein ehn-3

1

2

High-throughput

0.457

High

196342

KLF3
Kruppel-like factor 3

1

2

High-throughput

0.457

High

196345

SMA9
Transcription factor sma-9

1

2

High-throughput

0.457

High

196380

Q9U3S8
BED-type domain-containing protein

1

2

High-throughput

0.457

High

145866

O02289
C3H1-type domain-containing protein

1

1

High-throughput

0.451

High

196319

Q18937
RRM domain-containing protein

1

7

High-throughput

0.451

High

86639

B9WRT8
C3H1-type domain-containing protein

1

1

High-throughput

0.439

High

90581

C1P629
RRM domain-containing protein

1

6

High-throughput

0.439

High

116632

H9G305
Kelch domain-containing protein 10

1

2

High-throughput

0.439

High

196343

Q65ZJ0
Uncharacterized protein

1

1

High-throughput

0.439

High

196346

Q86DA8
C2H2-type domain-containing protein

1

0

High-throughput

0.438

High

196379

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.438

High

112472

G5EEG5
Kelch domain-containing protein 3

1

2

High-throughput

0.417

High

115866

H2L0B3
Uncharacterized protein

1

1

High-throughput

0.417

High

196328

Q21021
Nuclear Pore complex Protein

1

2

High-throughput

0.417

High

115426

H2KZ78
Reverse transcriptase domain-containing protein

2

0

High-throughput

0.334

High

196308

YL18
Uncharacterized protein C02F12.8

2

0

High-throughput

0.334

High

196386

Q9XXU2
Uncharacterized protein

2

0

High-throughput

0.334

High

113001

G5EF74
Serpentine Receptor, class D

1

0

High-throughput

0.282

High

116082

H2L0M8
Protein Upregulated in Glial Subsets

1

0

High-throughput

0.282

High

196285

O62020
GATA-type domain-containing protein

1

0

High-throughput

0.282

High

196292

YL87
Uncharacterized protein F54C8.7

1

0

High-throughput

0.282

High

196303

YR01
Uncharacterized protein T25E4.1

1

0

High-throughput

0.282

High

196310

Q17508
Uncharacterized protein

1

0

High-throughput

0.282

High

196311

YTE4
Uncharacterized protein C09G1.4

1

0

High-throughput

0.282

High

196312

Q17979
YDG domain-containing protein

1

0

High-throughput

0.282

High

196313

Q18043
Annexin A7

1

0

High-throughput

0.282

High

196323

Q19610
DUF148 domain-containing protein

1

0

High-throughput

0.282

High

196325

Q20677
WaRThog

1

0

High-throughput

0.282

High

196327

Q20968
LYSozyme

1

0

High-throughput

0.282

High

196333

Q22178
G patch domain-containing protein 11

1

0

High-throughput

0.282

High

196351

DYC1
Dystrophin-like protein 1

1

0

High-throughput

0.282

High

196361

Q9GUC8
IBR domain-containing protein

1

0

High-throughput

0.282

High

196364

Q9N3A3
Histone acetyltransferase

1

0

High-throughput

0.282

High

196366

Q9N4L9
SS18 N-terminal domain-containing protein

1

0

High-throughput

0.282

High

196369

Q9N582
RanBP2-type domain-containing protein

1

0

High-throughput

0.282

High

196278

O44505
C2H2-type domain-containing protein

1

0

High-throughput

0.265

Low

196354

Q93616
STI1 domain-containing protein

1

0

High-throughput

0.265

Low

196365

Q9N410
BHLH domain-containing protein

1

0

High-throughput

0.265

Low

196298

LST1
Lateral signaling target 1 protein

1

0

High-throughput

0.257

Low

196376

Q9U1S2
Bypass of Response to Pheromone in yeast

1

0

High-throughput

0.257

Low

115883

H2L0D2
WW domain-binding protein 11

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025