Protein: HIF1
Hypoxia-inducible factor 1 (Hypoxia-induced factor 1)

Gene: HIF1, hif-1
Organism: Caenorhabditis elegans
Interactions: 56
UniProt ID: G5EGD2

Gene Ontology (top 5):
GO:0000160 - phosphorelay signal transduction system
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001666 - response to hypoxia
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

113753

AHA1
Aryl hydrocarbon receptor nuclear translocator homolog

3

19

Small-scale

0.860

High

113765

LIN2
Protein lin-2

3

1

High-throughput

0.599

High

113776

APR1
Adenomatous polyposis coli protein-related protein 1

2

1

High-throughput

0.594

High

110994

G5ECN8
C2H2-type domain-containing protein

1

2

High-throughput

0.508

High

111442

PAX3H
Paired box protein 3 homolog

1

7

High-throughput

0.508

High

111992

G5EDU4
EOR-1

1

2

High-throughput

0.508

High

113751

O01960
C2H2-type domain-containing protein

1

1

High-throughput

0.508

High

113754

O02273
C2H2-type domain-containing protein

1

1

High-throughput

0.508

High

113755

NHR62
Nuclear hormone receptor family member nhr-62

1

20

High-throughput

0.508

High

113759

NH111
Nuclear hormone receptor family member nhr-111

1

20

High-throughput

0.508

High

113761

TAF9
Transcription initiation factor TFIID subunit 9

1

2

High-throughput

0.508

High

113762

KLF2
Kruppel-like factor 2

1

9

High-throughput

0.508

High

113763

O76398
C2H2-type domain-containing protein

1

2

High-throughput

0.508

High

113766

DPFF1
Zinc finger protein dpff-1

1

8

High-throughput

0.508

High

113768

FKH6
Forkhead transcription factor fkh-6

1

8

High-throughput

0.508

High

113769

PHA4
Defective pharyngeal development protein 4

1

7

High-throughput

0.508

High

113770

NHR43
Nuclear hormone receptor family member nhr-43

1

20

High-throughput

0.508

High

113774

Q19862
Transcription factor AP-2 C-terminal domain-containing protein

1

1

High-throughput

0.508

High

113777

Q21372
Nuclear Hormone Receptor family

1

20

High-throughput

0.508

High

113779

EGL13
Transcription factor egl-13

1

19

High-throughput

0.508

High

113784

MED11
Mediator of RNA polymerase II transcription subunit 11

1

1

High-throughput

0.508

High

113785

Q9BKZ8
Nuclear receptor domain-containing protein

1

20

High-throughput

0.508

High

113786

Q9N410
BHLH domain-containing protein

1

1

High-throughput

0.508

High

113789

KLF1
Kruppel-like factor 1

1

9

High-throughput

0.508

High

113790

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.508

High

113794

Q9XWJ8
Inhibitor of growth protein

1

1

High-throughput

0.508

High

112055

OVOLH
Transcription factor ovo-like homolog lin-48

1

0

High-throughput

0.486

High

113749

O01527
C2H2-type domain-containing protein

1

0

High-throughput

0.486

High

113778

Q22826
Fork-head domain-containing protein

1

0

High-throughput

0.486

High

113788

ODD2
Protein odd-skipped-related 2

1

0

High-throughput

0.486

High

113745

H2KZU3
NR LBD domain-containing protein

1

20

High-throughput

0.481

High

113752

O02174
C3H1-type domain-containing protein

1

1

High-throughput

0.481

High

113764

CBP1
Protein cbp-1

1

20

Small-scale

0.481

High

113783

Q86PI8
Nuclear receptor NHR-114

1

20

High-throughput

0.481

High

113758

O45491
C3H1-type domain-containing protein

1

3

High-throughput

0.464

High

113771

Q18477
Histone deacetylase 11

1

8

High-throughput

0.464

High

113775

Q21177
Uncharacterized protein

1

1

High-throughput

0.464

High

113780

MOE2
CCCH-type zinc finger protein oma-2

1

3

High-throughput

0.464

High

113792

MOE3
CCCH-type zinc finger protein moe-3

1

3

High-throughput

0.464

High

113772

VHL
von Hippel-Lindau tumor suppressor homolog

1

0

Small-scale

0.458

High

112599

NH114
Nuclear hormone receptor 114

1

20

High-throughput

0.457

High

113744

H2KZI6
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

113746

H2KZU4
NR LBD domain-containing protein

1

20

High-throughput

0.457

High

113748

UNC42
Homeobox protein unc-42

1

3

High-throughput

0.457

High

113781

EHN3
Zinc finger protein ehn-3

1

1

High-throughput

0.457

High

113782

SMA9
Transcription factor sma-9

1

2

High-throughput

0.457

High

113787

LSY2
Zinc finger protein lsy-2

1

1

High-throughput

0.457

High

113747

H9G331
non-specific serine/threonine protein kinase

1

7

Small-scale

0.439

High

113767

TX1B3
Tax1-binding protein 3 homolog

1

1

High-throughput

0.439

High

113791

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.438

High

113756

O44505
C2H2-type domain-containing protein

1

0

High-throughput

0.265

Low

113760

O45550
Protein Dr1

1

0

High-throughput

0.265

Low

113773

Q19760
JmjC domain-containing protein

1

0

High-throughput

0.265

Low

113793

Q9XW80
BZIP domain-containing protein

1

0

High-throughput

0.265

Low

113750

UNC89
Muscle M-line assembly protein unc-89

1

0

Small-scale

0.251

Low

113757

O45075
PHD-type domain-containing protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025