Protein: WDR59
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)

Gene: WDR59
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q6PJI9

Gene Ontology (top 5):
GO:0005765 - lysosomal membrane
GO:0005774 - vacuolar membrane
GO:0005829 - cytosol
GO:0031669 - cellular response to nutrient levels
GO:0032008 - positive regulation of TOR signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

878196

SEC13
Protein SEC13 homolog

7

20

Small-scale

0.966

High

1162296

WDR24
GATOR2 complex protein WDR24

5

18

Small-scale

0.932

High

1162291

SEH1
Nucleoporin SEH1

3

18

Small-scale

0.847

High

1031676

GRB10
Growth factor receptor-bound protein 10

2

7

High-throughput

0.811

High

254986

DEPD5
GATOR1 complex protein DEPDC5

2

4

Small-scale

0.754

High

245613

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

18

High-throughput

0.726

High

1162288

CAST1
Cytosolic arginine sensor for mTORC1 subunit 1

5

3

Small-scale

0.718

High

885130

SESN2
Sestrin-2

4

6

Small-scale

0.708

High

1162310

MIOS
GATOR2 complex protein MIOS

4

19

Small-scale

0.686

High

1162290

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.656

High

1162287

NPRL2
GATOR1 complex protein NPRL2

3

4

Small-scale

0.640

High

1021867

NPRL3
GATOR1 complex protein NPRL3

3

5

Small-scale

0.633

High

204685

E41L2
Band 4.1-like protein 2

2

3

High-throughput

0.628

High

1031221

SKP2
S-phase kinase-associated protein 2

2

5

High-throughput

0.628

High

1162306

DOCK5
Dedicator of cytokinesis protein 5

2

3

High-throughput

0.628

High

1162309

MOG1
Ran guanine nucleotide release factor

2

1

High-throughput

0.628

High

1162315

CRYL1
Lambda-crystallin homolog

2

3

High-throughput

0.628

High

234533

DSCAM
Cell adhesion molecule DSCAM

1

5

High-throughput

0.625

High

1070727

RBBP5
Retinoblastoma-binding protein 5

1

19

High-throughput

0.618

High

1073029

SF3B3
Splicing factor 3B subunit 3

1

20

High-throughput

0.618

High

1162302

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

18

High-throughput

0.618

High

1162286

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

13

High-throughput

0.618

High

1132329

SZT2
KICSTOR complex protein SZT2

2

1

Small-scale

0.611

High

1085262

NRF1
Nuclear respiratory factor 1

2

0

High-throughput

0.602

High

1162301

THTPA
Thiamine-triphosphatase

2

0

High-throughput

0.585

High

1162312

FAF1
FAS-associated factor 1

2

6

High-throughput

0.584

High

1162318

KPTN
KICSTOR complex protein kaptin

2

1

Small-scale

0.584

High

825062

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.578

High

260659

AVIL
Advillin

2

3

High-throughput

0.574

High

959488

VIGLN
Vigilin

2

20

High-throughput

0.574

High

1162279

NUP54
Nucleoporin p54

2

4

High-throughput

0.574

High

1162281

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

2

6

High-throughput

0.574

High

1162284

TSYL6
Testis-specific Y-encoded-like protein 6

2

3

High-throughput

0.574

High

1162303

PITH1
PITH domain-containing protein 1

2

2

High-throughput

0.574

High

1162311

CRNN
Cornulin

2

4

High-throughput

0.574

High

167090

ARHGB
Rho guanine nucleotide exchange factor 11

2

16

High-throughput

0.571

High

319885

HERC2
E3 ubiquitin-protein ligase HERC2

2

14

High-throughput

0.571

High

1162285

TXND5
Thioredoxin domain-containing protein 5

2

14

High-throughput

0.558

High

903313

WDR5
WD repeat-containing protein 5

1

18

Small-scale

0.553

High

943852

RAE1L
mRNA export factor RAE1

1

19

High-throughput

0.553

High

885147

SESN3
Sestrin-3

1

6

Small-scale

0.550

High

844114

FXR2
RNA-binding protein FXR2

1

9

High-throughput

0.541

High

63018

CAST2
Cytosolic arginine sensor for mTORC1 subunit 2

1

3

Small-scale

0.536

High

177324

HDAC3
Histone deacetylase 3

1

20

High-throughput

0.536

High

243465

DNJA2
DnaJ homolog subfamily A member 2

1

14

High-throughput

0.536

High

734957

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

14

High-throughput

0.536

High

943301

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

961165

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.536

High

1088094

UPP1
Uridine phosphorylase 1

1

1

High-throughput

0.536

High

1162278

TBA1A
Tubulin alpha-1A chain

1

17

High-throughput

0.536

High

1162299

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

1162305

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

1162316

PKHM1
Pleckstrin homology domain-containing family M member 1

1

3

Small-scale

0.536

High

277320

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

543029

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

996104

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.513

High

1140957

ANO1
Anoctamin-1

1

0

High-throughput

0.513

High

1162300

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.513

High

263263

SC22B
Vesicle-trafficking protein SEC22b

1

2

High-throughput

0.489

High

304976

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.489

High

450659

PAEP
Glycodelin

1

1

High-throughput

0.489

High

556892

CREB1
Cyclic AMP-responsive element-binding protein 1

1

3

High-throughput

0.489

High

1100064

INF2
Inverted formin-2

1

3

High-throughput

0.489

High

1162282

AN13A
Ankyrin repeat domain-containing protein 13A

1

5

High-throughput

0.489

High

1162283

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1162293

LOXL4
Lysyl oxidase homolog 4

1

1

High-throughput

0.489

High

1162294

F167A
Protein FAM167A

1

1

High-throughput

0.489

High

1162297

SIN3A
Paired amphipathic helix protein Sin3a

1

11

High-throughput

0.489

High

1162298

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.489

High

1162308

BRMS1
Breast cancer metastasis-suppressor 1

1

6

High-throughput

0.489

High

1162314

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.489

High

1162317

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.489

High

443596

VIME
Vimentin

1

6

High-throughput

0.481

High

998820

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.481

High

507074

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

Small-scale

0.479

High

527548

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

573322

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.479

High

598177

FLNA
Filamin-A

1

15

High-throughput

0.479

High

622594

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

2

High-throughput

0.479

High

684132

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

845009

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.479

High

845553

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

909695

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.479

High

1066278

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1151912

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1162280

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1162289

ITFG2
KICSTOR complex protein ITFG2

1

1

Small-scale

0.479

High

1162295

KICS2
KICSTOR subunit 2

1

1

Small-scale

0.479

High

1162307

ECT2
Protein ECT2

1

17

High-throughput

0.479

High

1162319

SESN1
Sestrin-1

1

6

Small-scale

0.479

High

1101125

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1162276

OLFM4
Olfactomedin-4

1

0

High-throughput

0.458

High

347095

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.437

High

385027

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

720737

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1162277

PKHG7
Pleckstrin homology domain-containing family G member 7

1

19

High-throughput

0.407

High

1162304

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.328

High

272362

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

942523

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.279

Low

1128324

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1162292

TRM61
tRNA

1

0

High-throughput

0.279

Low

1162313

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

352143

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024