Protein: TMX2
Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14)

Gene: TMX2
Organism: Homo sapiens
Interactions: 240
UniProt ID: Q9Y320

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005789 - endoplasmic reticulum membrane
GO:0007420 - brain development
GO:0015036 - disulfide oxidoreductase activity
GO:0031966 - mitochondrial membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491037

TMX2
Thioredoxin-related transmembrane protein 2

2

6

High-throughput

0.783

High

1358633

BT2A2
Butyrophilin subfamily 2 member A2

2

2

High-throughput

0.700

High

1491040

SRPRB
Signal recognition particle receptor subunit beta

3

3

High-throughput

0.667

High

1431798

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

3

3

High-throughput

0.653

High

328608

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

3

0

High-throughput

0.638

High

940097

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

3

0

High-throughput

0.638

High

1403506

KCNKG
Potassium channel subfamily K member 16

3

0

High-throughput

0.638

High

1359376

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

2

High-throughput

0.628

High

669292

PTAFR
Platelet-activating factor receptor

1

1

High-throughput

0.625

High

936141

PAR2
Proteinase-activated receptor 2

1

1

High-throughput

0.625

High

1438496

RXFP1
Relaxin receptor 1

1

1

High-throughput

0.618

High

333263

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

1

High-throughput

0.606

High

720077

HMOX2
Heme oxygenase 2

2

2

High-throughput

0.606

High

934299

BI1
Bax inhibitor 1

2

1

High-throughput

0.606

High

1050074

PLP2
Proteolipid protein 2

2

1

High-throughput

0.606

High

1152897

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

2

2

High-throughput

0.606

High

1359673

GIMA1
GTPase IMAP family member 1

2

4

High-throughput

0.606

High

1406203

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

2

5

High-throughput

0.606

High

1411250

REEP2
Receptor expression-enhancing protein 2

2

1

High-throughput

0.606

High

1414512

DERL1
Derlin-1

2

1

High-throughput

0.606

High

1414545

HTAI2
Protein HTATIP2

2

2

High-throughput

0.606

High

1416311

SFXN3
Sideroflexin-3

2

1

High-throughput

0.606

High

1434964

REEP4
Receptor expression-enhancing protein 4

2

1

High-throughput

0.606

High

1436977

SFXN1
Sideroflexin-1

2

1

High-throughput

0.606

High

1449030

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

2

2

High-throughput

0.606

High

1449034

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

2

2

High-throughput

0.606

High

1449822

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.606

High

1450032

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

2

2

High-throughput

0.606

High

1453853

VAPA
Vesicle-associated membrane protein-associated protein A

2

1

High-throughput

0.606

High

1454002

TM14C
Transmembrane protein 14C

2

1

High-throughput

0.606

High

595128

KCNA2
Potassium voltage-gated channel subfamily A member 2

2

2

High-throughput

0.601

High

858209

BKRB1
B1 bradykinin receptor

1

0

High-throughput

0.584

High

869812

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.584

High

144504

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

155522

C2C2L
Phospholipid transfer protein C2CD2L

2

0

High-throughput

0.580

High

162292

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.580

High

167028

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.580

High

180115

BET1
BET1 homolog

2

0

High-throughput

0.580

High

325625

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

328280

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

2

0

High-throughput

0.580

High

331496

LRAT
Lecithin retinol acyltransferase

2

0

High-throughput

0.580

High

341492

CDS2
Phosphatidate cytidylyltransferase 2

2

0

High-throughput

0.580

High

789979

FDFT
Squalene synthase

2

0

High-throughput

0.580

High

843354

NSG1
Neuronal vesicle trafficking-associated protein 1

2

0

High-throughput

0.580

High

858587

IEX1
Radiation-inducible immediate-early gene IEX-1

2

0

High-throughput

0.580

High

941762

TM50B
Transmembrane protein 50B

2

0

High-throughput

0.580

High

1005421

CP4F2
Cytochrome P450 4F2

2

0

High-throughput

0.580

High

1086146

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.580

High

1092001

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.580

High

1092105

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

2

0

High-throughput

0.580

High

1198956

ORML2
ORM1-like protein 2

2

0

High-throughput

0.580

High

1209052

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

2

0

High-throughput

0.580

High

1243006

TMM71
Transmembrane protein 71

2

0

High-throughput

0.580

High

1244676

TMM65
Transmembrane protein 65

2

0

High-throughput

0.580

High

1251317

HACD2
Very-long-chain

2

0

High-throughput

0.580

High

1253317

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

0

High-throughput

0.580

High

1272384

FA2H
Fatty acid 2-hydroxylase

2

0

High-throughput

0.580

High

1328723

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

0

High-throughput

0.580

High

1328824

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.580

High

1329676

SERP2
Stress-associated endoplasmic reticulum protein 2

2

0

High-throughput

0.580

High

1381091

TM203
Transmembrane protein 203

2

0

High-throughput

0.580

High

1382732

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

2

0

High-throughput

0.580

High

1394426

FXDC2
Fatty acid hydroxylase domain-containing protein 2

2

0

High-throughput

0.580

High

1410444

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.580

High

1413818

TM208
Transmembrane protein 208

2

0

High-throughput

0.580

High

1416224

FUND2
FUN14 domain-containing protein 2

2

0

High-throughput

0.580

High

1429151

MFF
Mitochondrial fission factor

2

0

High-throughput

0.580

High

1431695

ARV1
Protein ARV1

2

0

High-throughput

0.580

High

1439401

HHATL
Protein-cysteine N-palmitoyltransferase HHAT-like protein

2

0

High-throughput

0.580

High

1449458

TREX1
Three-prime repair exonuclease 1

2

0

High-throughput

0.580

High

1449587

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

0

High-throughput

0.580

High

1459911

NAT8
N-acetyltransferase 8

2

0

High-throughput

0.580

High

1491038

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

0

High-throughput

0.580

High

1491041

INSI2
Insulin-induced gene 2 protein

2

0

High-throughput

0.580

High

1491042

IR3IP
Immediate early response 3-interacting protein 1

2

0

High-throughput

0.580

High

1491043

PEX16
Peroxisomal membrane protein PEX16

2

0

High-throughput

0.580

High

1491044

SELK
Selenoprotein K

2

0

High-throughput

0.580

High

648849

KCNA5
Potassium voltage-gated channel subfamily A member 5

2

2

High-throughput

0.574

High

1156956

CNGA3
Cyclic nucleotide-gated channel alpha-3

2

1

High-throughput

0.574

High

1421375

S39A8
Metal cation symporter ZIP8

2

2

High-throughput

0.574

High

1042794

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

2

High-throughput

0.558

High

49715

T120B
Transmembrane protein 120B

2

1

High-throughput

0.553

High

183888

OBRG
Leptin receptor gene-related protein

2

1

High-throughput

0.553

High

189944

STX7
Syntaxin-7

2

4

High-throughput

0.553

High

252643

TSN2
Tetraspanin-2

2

1

High-throughput

0.553

High

257687

PRAF2
PRA1 family protein 2

2

2

High-throughput

0.553

High

278583

VAMP4
Vesicle-associated membrane protein 4

2

3

High-throughput

0.553

High

328765

VAMP5
Vesicle-associated membrane protein 5

2

4

High-throughput

0.553

High

329680

LERL1
Leptin receptor overlapping transcript-like 1

2

1

High-throughput

0.553

High

451680

TRBM
Thrombomodulin

2

1

High-throughput

0.553

High

539504

ITAM
Integrin alpha-M

2

1

High-throughput

0.553

High

662369

VAMP1
Vesicle-associated membrane protein 1

2

3

High-throughput

0.553

High

719090

MIP
Lens fiber major intrinsic protein

2

1

High-throughput

0.553

High

849050

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

2

High-throughput

0.553

High

932775

EMP3
Epithelial membrane protein 3

2

1

High-throughput

0.553

High

948968

CD81
CD81 antigen

2

1

High-throughput

0.553

High

1100744

STX3
Syntaxin-3

2

2

High-throughput

0.553

High

1109097

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

1154790

VAMP3
Vesicle-associated membrane protein 3

2

4

High-throughput

0.553

High

1210329

MF14B
Hippocampus abundant transcript-like protein 1

2

2

High-throughput

0.553

High

1279396

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

3

High-throughput

0.553

High

1294869

STX12
Syntaxin-12

2

4

High-throughput

0.553

High

1334071

DHB11
Estradiol 17-beta-dehydrogenase 11

2

3

High-throughput

0.553

High

1384639

S67A1
Solute carrier family 67 member A1

2

2

High-throughput

0.553

High

1390253

GIMA5
GTPase IMAP family member 5

2

4

High-throughput

0.553

High

1391138

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

1

High-throughput

0.553

High

1416329

YIPF2
Protein YIPF2

2

1

High-throughput

0.553

High

1416871

TACAN
Transmembrane protein 120A

2

1

High-throughput

0.553

High

1460197

PRAF1
Prenylated Rab acceptor protein 1

2

2

High-throughput

0.553

High

1490447

RNF24
RING finger protein 24

2

1

High-throughput

0.553

High

1491039

YIPF1
Protein YIPF1

2

1

High-throughput

0.553

High

565746

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

1

High-throughput

0.549

High

547346

CP19A
Aromatase

1

1

High-throughput

0.536

High

699278

CALX
Calnexin

1

1

High-throughput

0.536

High

773696

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.536

High

397279

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

927626

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

1381369

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

1382254

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1454159

TM63C
Osmosensitive cation channel TMEM63C

1

0

High-throughput

0.513

High

851245

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

1

High-throughput

0.489

High

880223

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.489

High

1308522

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

1

High-throughput

0.489

High

63839

PEDS1
Plasmanylethanolamine desaturase 1

1

1

High-throughput

0.481

High

483988

HMOX1
Heme oxygenase 1

1

2

High-throughput

0.481

High

1406411

MGLL
Monoglyceride lipase

1

1

High-throughput

0.481

High

174156

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

705871

DHI1
11-beta-hydroxysteroid dehydrogenase 1

1

3

High-throughput

0.479

High

2845

A0A0C4DFN3
Monoglyceride lipase

1

1

High-throughput

0.470

High

48211

A0AVG3
t-SNARE domain containing 1

1

4

High-throughput

0.470

High

116737

I3L0A0
HCG2044781

1

4

High-throughput

0.470

High

1196852

Q4VAQ0
COL8A2 protein

1

3

High-throughput

0.470

High

1202538

Q59EV6
Carboxypeptidase

1

1

High-throughput

0.470

High

1390459

Q96FB2
SLC29A2 protein

1

1

High-throughput

0.470

High

1421302

THS7B
Thrombospondin type-1 domain-containing protein 7B

1

2

High-throughput

0.470

High

1447792

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1490850

S27A5
Long-chain fatty acid transport protein 5

1

2

High-throughput

0.445

High

407926

PRP1
Basic salivary proline-rich protein 1

1

1

High-throughput

0.439

High

528730

PPGB
Lysosomal protective protein

1

1

High-throughput

0.439

High

668797

CO8A2
Collagen alpha-2(VIII) chain

1

3

High-throughput

0.439

High

1127902

S29A2
Equilibrative nucleoside transporter 2

1

1

High-throughput

0.439

High

1398908

TSNA1
t-SNARE domain-containing protein 1

1

4

High-throughput

0.439

High

218991

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

590092

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

623602

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.437

High

696932

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769578

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1163445

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.437

High

1256200

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1335091

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.437

High

1360217

5HT3C
5-hydroxytryptamine receptor 3C

1

2

High-throughput

0.437

High

1434295

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1459589

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

1

High-throughput

0.437

High

1462011

ALK
ALK tyrosine kinase receptor

1

5

Small-scale

0.437

High

1291529

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.426

High

1391535

BSCL2
Seipin

1

0

High-throughput

0.426

High

835422

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.407

High

869696

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

1

High-throughput

0.407

High

870336

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.407

High

1103465

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.407

High

1197910

S39AC
Zinc transporter ZIP12

1

2

High-throughput

0.407

High

1203845

TTMP
TPA-induced transmembrane protein

3

0

High-throughput

0.346

High

1450144

OTULL
Inactive ubiquitin thioesterase OTULINL

3

0

High-throughput

0.340

High

252293

TLR5
Toll-like receptor 5

2

0

High-throughput

0.328

High

1180873

S4A8
Electroneutral sodium bicarbonate exchanger 1

2

0

High-throughput

0.328

High

1390905

ASIC4
Acid-sensing ion channel 4

2

0

High-throughput

0.328

High

74201

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.316

High

297325

SERF1
Small EDRK-rich factor 1

2

0

High-throughput

0.316

High

391762

STAT
Statherin

2

0

High-throughput

0.316

High

455945

ASGR1
Asialoglycoprotein receptor 1

2

0

High-throughput

0.316

High

482275

PAEP
Glycodelin

2

0

High-throughput

0.316

High

549466

CD20
B-lymphocyte antigen CD20

2

0

High-throughput

0.316

High

556628

MOTI
Promotilin [Cleaved into: Motilin; Motilin-associated peptide

2

0

High-throughput

0.316

High

562858

CCL2
C-C motif chemokine 2

2

0

High-throughput

0.316

High

666038

IBP5
Insulin-like growth factor-binding protein 5

2

0

High-throughput

0.316

High

706062

CXB2
Gap junction beta-2 protein

2

0

High-throughput

0.316

High

895171

EMD
Emerin

2

0

High-throughput

0.316

High

928885

LIPR1
Inactive pancreatic lipase-related protein 1

2

0

High-throughput

0.316

High

1007422

S35A1
CMP-sialic acid transporter

2

0

High-throughput

0.316

High

1081336

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.316

High

1089170

TM115
Transmembrane protein 115

2

0

High-throughput

0.316

High

1092040

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

2

0

High-throughput

0.316

High

1092840

MALL
MAL-like protein

2

0

High-throughput

0.316

High

1127337

WFDC2
WAP four-disulfide core domain protein 2

2

0

High-throughput

0.316

High

1195556

CTXN3
Cortexin-3

2

0

High-throughput

0.316

High

1203149

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.316

High

1203355

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

1206203

CX066
Uncharacterized protein CXorf66

2

0

High-throughput

0.316

High

1208749

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

1210024

TM201
Transmembrane protein 201

2

0

High-throughput

0.316

High

1245947

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.316

High

1256663

TPRG1
Tumor protein p63-regulated gene 1 protein

2

0

High-throughput

0.316

High

1292383

UN93A
Protein unc-93 homolog A

2

0

High-throughput

0.316

High

1312833

NRM
Nurim

2

0

High-throughput

0.316

High

1322732

F177A
Protein FAM177A1

2

0

High-throughput

0.316

High

1346733

SCAM5
Secretory carrier-associated membrane protein 5

2

0

High-throughput

0.316

High

1347222

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.316

High

1349024

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

1357645

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.316

High

1359048

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1363581

FAM3C
Protein FAM3C

2

0

High-throughput

0.316

High

1386938

F241B
Protein FAM241B

2

0

High-throughput

0.316

High

1388820

YIPF6
Protein YIPF6

2

0

High-throughput

0.316

High

1392199

RUSF1
RUS family member 1

2

0

High-throughput

0.316

High

1393362

T176A
Transmembrane protein 176A

2

0

High-throughput

0.316

High

1413374

TM121
Transmembrane protein 121

2

0

High-throughput

0.316

High

1430299

TM222
Transmembrane protein 222

2

0

High-throughput

0.316

High

1448768

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.316

High

1450223

TM140
Transmembrane protein 140

2

0

High-throughput

0.316

High

1450885

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.316

High

1451128

TMM51
Transmembrane protein 51

2

0

High-throughput

0.316

High

1452878

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

0

High-throughput

0.316

High

1453242

NINJ2
Ninjurin-2

2

0

High-throughput

0.316

High

1453738

CC167
Coiled-coil domain-containing protein 167

2

0

High-throughput

0.316

High

1106818

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

0

High-throughput

0.279

Low

1329607

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

1331211

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.279

Low

1390375

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1411167

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

0

High-throughput

0.279

Low

63353

A5D903
PRB1 protein

1

0

High-throughput

0.268

Low

1451664

COMD8
COMM domain-containing protein 8

1

0

High-throughput

0.265

Low

183985

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.251

Low

1207792

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

1430288

FXYD6
FXYD domain-containing ion transport regulator 6

1

0

High-throughput

0.251

Low

1431629

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.251

Low

178447

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

227717

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

828474

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.249

Low

1005271

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1288128

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

0

High-throughput

0.249

Low

1406336

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.249

Low

1449741

GINM1
Glycoprotein integral membrane protein 1

1

0

High-throughput

0.249

Low

248961

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

1236384

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1242276

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

1338787

NCKX4
Sodium/potassium/calcium exchanger 4

1

0

High-throughput

0.232

Low

1350621

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.232

Low

1389633

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

1401558

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025