Protein: TFE2
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)

Gene: TFE2, TCF3
Organism: Homo sapiens
Interactions: 181
UniProt ID: P15923

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551464

TAL1
T-cell acute lymphocytic leukemia protein 1

9

20

Small-scale

0.976

High

551502

ID2
DNA-binding protein inhibitor ID-2

8

20

Small-scale

0.975

High

551503

ID3
DNA-binding protein inhibitor ID-3

8

20

Small-scale

0.972

High

551478

ID1
DNA-binding protein inhibitor ID-1

8

20

Small-scale

0.971

High

546066

MYOG
Myogenin

6

20

Small-scale

0.947

High

545932

MYOD1
Myoblast determination protein 1

5

20

Small-scale

0.934

High

551530

TWST1
Twist-related protein 1

5

20

Small-scale

0.928

High

551521

NDF1
Neurogenic differentiation factor 1

4

20

Small-scale

0.899

High

551462

TFE2
Transcription factor E2-alpha

4

13

Small-scale

0.882

High

551056

ITF2
Transcription factor 4

3

13

High-throughput

0.863

High

551472

MYF6
Myogenic factor 6

3

20

Small-scale

0.863

High

551514

MESP2
Mesoderm posterior protein 2

3

6

High-throughput

0.861

High

551559

TWST2
Twist-related protein 2

3

20

High-throughput

0.858

High

551578

ASCL3
Achaete-scute homolog 3

3

20

High-throughput

0.858

High

551486

ASCL1
Achaete-scute homolog 1

3

20

Small-scale

0.852

High

330420

HAND1
Heart- and neural crest derivatives-expressed protein 1

3

20

Small-scale

0.849

High

551569

FER3L
Fer3-like protein

2

20

High-throughput

0.811

High

551594

NGN3
Neurogenin-3

2

20

High-throughput

0.811

High

551572

MESP1
Mesoderm posterior protein 1

2

6

Small-scale

0.793

High

551490

HAND2
Heart- and neural crest derivatives-expressed protein 2

2

20

Small-scale

0.793

High

551504

HEN1
Helix-loop-helix protein 1

2

20

Small-scale

0.793

High

551505

HEN2
Helix-loop-helix protein 2

2

20

High-throughput

0.789

High

526739

MYF5
Myogenic factor 5

2

20

Small-scale

0.767

High

551480

ID4
DNA-binding protein inhibitor ID-4

2

20

Small-scale

0.754

High

524532

LYL1
Protein lyl-1

1

20

Small-scale

0.740

High

551560

CBP
CREB-binding protein

6

10

Small-scale

0.740

High

146451

BHE40
Class E basic helix-loop-helix protein 40

1

8

Small-scale

0.713

High

210857

TCF21
Transcription factor 21

1

20

Small-scale

0.713

High

551470

USF1
Upstream stimulatory factor 1

1

6

Small-scale

0.713

High

63036

MSGN1
Mesogenin-1

1

20

High-throughput

0.691

High

238585

MUSC
Musculin

1

20

High-throughput

0.691

High

551515

TCF15
Transcription factor 15

1

20

High-throughput

0.691

High

551533

TAL2
T-cell acute lymphocytic leukemia protein 2

1

20

High-throughput

0.691

High

551540

FIGLA
Factor in the germline alpha

1

20

High-throughput

0.691

High

551542

ASCL4
Achaete-scute homolog 4

1

20

High-throughput

0.691

High

551546

TCF23
Transcription factor 23

1

20

High-throughput

0.691

High

551565

NGN1
Neurogenin-1

1

20

High-throughput

0.691

High

551577

NDF4
Neurogenic differentiation factor 4

1

20

High-throughput

0.691

High

551558

LMX1A
LIM homeobox transcription factor 1-alpha

1

3

Small-scale

0.680

High

551513

EP300
Histone acetyltransferase p300

3

9

Small-scale

0.670

High

551571

HTF4
Transcription factor 12

1

13

Small-scale

0.665

High

551562

KAT2B
Histone acetyltransferase KAT2B

2

4

Small-scale

0.629

High

253965

MTG16
Protein CBFA2T3

2

9

Small-scale

0.624

High

551547

SCX
Basic helix-loop-helix transcription factor scleraxis

1

20

Small-scale

0.621

High

345842

MYC
Myc proto-oncogene protein

1

6

Small-scale

0.618

High

378985

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.618

High

551520

OLIG2
Oligodendrocyte transcription factor 2

1

20

Small-scale

0.618

High

551543

BHA15
Class A basic helix-loop-helix protein 15

1

20

High-throughput

0.618

High

551544

PTF1A
Pancreas transcription factor 1 subunit alpha

1

20

Small-scale

0.618

High

551545

TCF24
Transcription factor 24

1

20

High-throughput

0.618

High

551553

ATOH7
Transcription factor ATOH7

1

20

Small-scale

0.618

High

551557

OLIG1
Oligodendrocyte transcription factor 1

1

20

Small-scale

0.618

High

551564

ATOH1
Transcription factor ATOH1

1

20

Small-scale

0.618

High

551570

ATOH8
Transcription factor ATOH8

1

20

High-throughput

0.618

High

551506

TLE1
Transducin-like enhancer protein 1

2

8

Small-scale

0.602

High

551561

KAT2A
Histone acetyltransferase KAT2A

2

11

Small-scale

0.602

High

551482

SOX2
Transcription factor SOX-2

2

4

Small-scale

0.584

High

551501

RUNX1
Runt-related transcription factor 1

2

1

Small-scale

0.584

High

551517

SKP2
S-phase kinase-associated protein 2

2

0

Small-scale

0.559

High

455052

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.552

High

551534

MAPK3
MAP kinase-activated protein kinase 3

1

1

Small-scale

0.549

High

122477

MEN1
Menin

1

0

Small-scale

0.537

High

122144

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

Small-scale

0.536

High

551575

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

551489

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.529

High

551497

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.527

High

551491

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.518

High

270760

FOXH1
Forkhead box protein H1

1

2

Small-scale

0.515

High

443304

VIME
Vimentin

1

1

High-throughput

0.515

High

551541

BCOR
BCL-6 corepressor

1

0

High-throughput

0.513

High

551556

KI18A
Kinesin-like protein KIF18A

1

0

High-throughput

0.513

High

310127

CCDB1
Cyclin-D1-binding protein 1

1

0

Small-scale

0.506

High

124159

TAF4
Transcription initiation factor TFIID subunit 4

1

1

Small-scale

0.501

High

266308

TAD2A
Transcriptional adapter 2-alpha

1

4

Small-scale

0.501

High

551483

MAPK2
MAP kinase-activated protein kinase 2

1

1

Small-scale

0.501

High

551584

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.501

High

551463

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

551468

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.493

High

160360

AURKA
Aurora kinase A

1

0

High-throughput

0.480

High

266470

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.480

High

551554

GLIS1
Zinc finger protein GLIS1

1

0

High-throughput

0.480

High

551573

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.480

High

551586

DACH1
Dachshund homolog 1

1

0

High-throughput

0.480

High

551592

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.480

High

153557

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.479

High

162386

XPO1
Exportin-1

1

2

High-throughput

0.479

High

214493

MYO1B
Unconventional myosin-Ib

1

1

High-throughput

0.479

High

231988

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

318568

EYA4
Eyes absent homolog 4

1

1

High-throughput

0.479

High

483594

SETLP
Protein SETSIP

1

1

High-throughput

0.479

High

487104

ANDR
Androgen receptor

1

1

Small-scale

0.479

High

551465

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

551473

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

551477

C2TA
MHC class II transactivator

1

1

Small-scale

0.479

High

551479

ELK3
ETS domain-containing protein Elk-3

1

2

Small-scale

0.479

High

551481

LEG7
Galectin-7

1

2

High-throughput

0.479

High

551484

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

551494

H4
Histone H4

1

1

High-throughput

0.479

High

551496

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.479

High

551507

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

551510

MTG8
Protein CBFA2T1

1

9

Small-scale

0.479

High

551522

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

551531

ELAV1
ELAV-like protein 1

1

1

High-throughput

0.479

High

551537

FILA2
Filaggrin-2

1

2

High-throughput

0.479

High

551539

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

551548

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

Small-scale

0.479

High

551549

LDB1
LIM domain-binding protein 1

1

2

Small-scale

0.479

High

551563

DDX17
Probable ATP-dependent RNA helicase DDX17

1

2

High-throughput

0.479

High

551566

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.479

High

551582

RNF14
E3 ubiquitin-protein ligase RNF14

1

3

Small-scale

0.479

High

551583

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.479

High

551585

DDX20
Probable ATP-dependent RNA helicase DDX20

1

6

High-throughput

0.479

High

551587

RCOR1
REST corepressor 1

1

2

High-throughput

0.479

High

551588

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

Small-scale

0.479

High

551589

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

530821

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.470

High

551523

CASL
Enhancer of filamentation 1

1

0

Small-scale

0.460

High

153868

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

High-throughput

0.458

High

202046

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

0

High-throughput

0.458

High

299837

ERLN2
Erlin-2

1

0

High-throughput

0.458

High

306450

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

High-throughput

0.458

High

345050

CYTA
Cystatin-A

1

0

High-throughput

0.458

High

414154

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

518955

PIP
Prolactin-inducible protein

1

0

High-throughput

0.458

High

551466

SON
Protein SON

1

0

High-throughput

0.458

High

551469

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

551471

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.458

High

551474

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

551476

CASPE
Caspase-14

1

0

High-throughput

0.458

High

551487

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

551492

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

551493

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

551495

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

551499

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

551508

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

551509

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.458

High

551511

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

551516

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

551525

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.458

High

551527

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.458

High

551528

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

551529

SAFB1
Scaffold attachment factor B1

1

0

High-throughput

0.458

High

551536

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.458

High

551538

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

551550

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

551555

IN80E
INO80 complex subunit E

1

0

High-throughput

0.458

High

551576

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.458

High

551579

LANC2
LanC-like protein 2

1

0

High-throughput

0.458

High

551580

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

551595

SPIN1
Spindlin-1

1

0

High-throughput

0.458

High

551467

NUCL
Nucleolin

1

1

Small-scale

0.457

High

551590

RUVB2
RuvB-like 2

1

1

High-throughput

0.445

High

551591

RUVB1
RuvB-like 1

1

1

High-throughput

0.445

High

271519

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.437

High

551485

SERPH
Serpin H1

1

1

High-throughput

0.437

High

551524

GSE1
Genetic suppressor element 1

1

1

High-throughput

0.437

High

551535

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.437

High

551567

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.437

High

551593

TCAF1
TRPM8 channel-associated factor 1

3

0

High-throughput

0.352

High

311314

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

0

High-throughput

0.328

High

551552

GT252
Procollagen galactosyltransferase 2

2

0

High-throughput

0.328

High

551518

PLD1
Phospholipase D1

1

0

High-throughput

0.268

Low

280198

CBPD
Carboxypeptidase D

1

0

High-throughput

0.249

Low

390699

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

518078

ADT1
ADP/ATP translocase 1

1

0

High-throughput

0.249

Low

537192

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.249

Low

538634

MYL6B
Myosin light chain 6B

1

0

High-throughput

0.249

Low

551475

CALX
Calnexin

1

0

High-throughput

0.249

Low

551488

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.249

Low

551498

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.249

Low

551500

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.249

Low

551512

TFF3
Trefoil factor 3

1

0

High-throughput

0.249

Low

551519

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.249

Low

551526

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.249

Low

551532

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

551551

DJC10
DnaJ homolog subfamily C member 10

1

0

High-throughput

0.249

Low

551568

ASB2
Ankyrin repeat and SOCS box protein 2

1

0

Small-scale

0.249

Low

551574

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.249

Low

551581

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.249

Low

344157

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024