Protein: JIP4
C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)

Gene: JIP4, SPAG9
Organism: Homo sapiens
Interactions: 185
UniProt ID: O60271

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0005078 - MAP-kinase scaffold activity
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

243921

ARF6
ADP-ribosylation factor 6

4

9

Small-scale

0.900

High

243887

NFKB1
Nuclear factor NF-kappa-B p105 subunit

4

11

High-throughput

0.887

High

244031

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

18

High-throughput

0.811

High

243869

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

17

Small-scale

0.768

High

243914

PLK1
Serine/threonine-protein kinase PLK1

8

3

Small-scale

0.752

High

64839

RCCD1
RCC1 domain-containing protein 1

4

4

High-throughput

0.697

High

243999

ARL5B
ADP-ribosylation factor-like protein 5B

1

10

High-throughput

0.691

High

141887

PODXL
Podocalyxin

3

3

High-throughput

0.662

High

243923

ARF1
ADP-ribosylation factor 1

1

9

Small-scale

0.647

High

243905

EAA3
Excitatory amino acid transporter 3

3

2

High-throughput

0.643

High

243974

MREG
Melanoregulin

3

0

High-throughput

0.638

High

243935

SCRB2
Lysosome membrane protein 2

3

0

High-throughput

0.634

High

166223

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

2

High-throughput

0.628

High

243880

TPM3
Tropomyosin alpha-3 chain

2

10

High-throughput

0.628

High

243881

SYPH
Synaptophysin

2

1

High-throughput

0.628

High

243882

TPM1
Tropomyosin alpha-1 chain

2

8

High-throughput

0.628

High

243897

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.618

High

243930

ARL16
ADP-ribosylation factor-like protein 16

1

15

High-throughput

0.618

High

243932

ANK3
Ankyrin-3

1

8

High-throughput

0.618

High

243886

LEUK
Leukosialin

2

0

High-throughput

0.602

High

243976

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

0

High-throughput

0.602

High

243889

EPHA1
Ephrin type-A receptor 1

2

7

High-throughput

0.601

High

244002

VPS35
Vacuolar protein sorting-associated protein 35

2

1

High-throughput

0.601

High

243917

RAB8A
Ras-related protein Rab-8A

2

10

Small-scale

0.588

High

243875

ZBED1
E3 SUMO-protein ligase ZBED1

2

1

High-throughput

0.574

High

243939

SMCO1
Single-pass membrane and coiled-coil domain-containing protein 1

2

1

High-throughput

0.574

High

244001

MERB1
bMERB domain-containing protein 1

2

1

High-throughput

0.574

High

243915

TERA
Transitional endoplasmic reticulum ATPase

2

6

High-throughput

0.571

High

243977

ARL10
ADP-ribosylation factor-like protein 10

1

13

High-throughput

0.553

High

243931

TP53B
TP53-binding protein 1

1

7

High-throughput

0.552

High

244029

CC018
Uncharacterized protein C3orf18

2

1

High-throughput

0.549

High

165728

PPE2
Serine/threonine-protein phosphatase with EF-hands 2

1

13

High-throughput

0.536

High

226387

SNG2
Synaptogyrin-2

1

1

High-throughput

0.536

High

226633

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

9

High-throughput

0.536

High

243874

TSN15
Tetraspanin-15

1

7

High-throughput

0.536

High

243890

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

11

High-throughput

0.536

High

243893

MK01
Mitogen-activated protein kinase 1

1

5

High-throughput

0.536

High

243896

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

1

High-throughput

0.536

High

243900

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

20

High-throughput

0.536

High

243916

TPTE
Putative tyrosine-protein phosphatase TPTE

1

5

High-throughput

0.536

High

243941

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

243950

KLH40
Kelch-like protein 40

1

3

High-throughput

0.536

High

243959

T184A
Transmembrane protein 184A

1

1

High-throughput

0.536

High

243962

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

1

High-throughput

0.536

High

243986

NEK7
Serine/threonine-protein kinase Nek7

1

17

High-throughput

0.536

High

243990

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

19

High-throughput

0.536

High

243995

BIRC7
Baculoviral IAP repeat-containing protein 7

1

5

High-throughput

0.536

High

244000

KI16B
Kinesin-like protein KIF16B

1

8

High-throughput

0.536

High

244003

PSKH2
Serine/threonine-protein kinase H2

1

5

High-throughput

0.536

High

244004

EYA1
Protein phosphatase EYA1

1

6

High-throughput

0.536

High

244035

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.536

High

243936

IF4A2
Eukaryotic initiation factor 4A-II

1

9

High-throughput

0.515

High

186175

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.513

High

243872

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.513

High

243912

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

243943

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.513

High

243954

VASN
Vasorin

1

0

High-throughput

0.513

High

243961

CYS1
Cystin-1

1

0

High-throughput

0.513

High

243964

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.513

High

243988

ACO12
Acetyl-coenzyme A thioesterase

1

0

High-throughput

0.513

High

243996

ATG4C
Cysteine protease ATG4C

1

0

High-throughput

0.513

High

244006

PDD2L
Programmed cell death protein 2-like

1

0

High-throughput

0.513

High

244015

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

243920

MAX
Protein max

1

5

Small-scale

0.512

High

244009

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.508

High

243992

EXOC4
Exocyst complex component 4

1

0

Small-scale

0.493

High

243993

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.493

High

226295

SNG1
Synaptogyrin-1

1

1

High-throughput

0.489

High

243883

F163B
Protein FAM163B

1

1

High-throughput

0.489

High

243913

EFNA4
Ephrin-A4

1

5

High-throughput

0.489

High

243957

STYK1
Tyrosine-protein kinase STYK1

1

12

High-throughput

0.489

High

243958

BTNL9
Butyrophilin-like protein 9

1

6

High-throughput

0.489

High

243980

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.489

High

243983

SYNPR
Synaptoporin

1

1

High-throughput

0.489

High

243997

F163A
Protein FAM163A

1

1

High-throughput

0.489

High

244013

CBX8
Chromobox protein homolog 8

1

7

High-throughput

0.489

High

244021

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

High-throughput

0.489

High

244034

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

5

High-throughput

0.489

High

244037

T184B
Transmembrane protein 184B

1

1

High-throughput

0.489

High

244016

PNRC2
Proline-rich nuclear receptor coactivator 2

1

0

High-throughput

0.486

High

243901

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

240214

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

243871

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

243873

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.479

High

243876

ABL1
Tyrosine-protein kinase ABL1

1

7

Small-scale

0.479

High

243877

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

243879

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

243884

BCR
Breakpoint cluster region protein

1

13

High-throughput

0.479

High

243885

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

243894

PML
Protein PML

1

10

High-throughput

0.479

High

243895

WEE1
Wee1-like protein kinase

1

18

High-throughput

0.479

High

243902

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

243903

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

243904

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

243906

MK08
Mitogen-activated protein kinase 8

1

20

Small-scale

0.479

High

243907

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

20

Small-scale

0.479

High

243908

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

Small-scale

0.479

High

243909

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

243910

MCM2
DNA replication licensing factor MCM2

1

16

High-throughput

0.479

High

243911

RAB9A
Ras-related protein Rab-9A

1

11

High-throughput

0.479

High

243918

RAB10
Ras-related protein Rab-10

1

10

Small-scale

0.479

High

243919

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

243922

H31
Histone H3.1

1

6

High-throughput

0.479

High

243924

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

243926

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

243927

KIF23
Kinesin-like protein KIF23

1

11

High-throughput

0.479

High

243928

SOX4
Transcription factor SOX-4

1

3

High-throughput

0.479

High

243929

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

243933

TP4A2
Protein tyrosine phosphatase type IVA 2

1

5

High-throughput

0.479

High

243934

CUL4A
Cullin-4A

1

12

High-throughput

0.479

High

243937

MCM6
DNA replication licensing factor MCM6

1

16

High-throughput

0.479

High

243938

SMC1A
Structural maintenance of chromosomes protein 1A

1

17

High-throughput

0.479

High

243940

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

9

High-throughput

0.479

High

243942

EEA1
Early endosome antigen 1

1

18

High-throughput

0.479

High

243945

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.479

High

243953

RN123
E3 ubiquitin-protein ligase RNF123

1

12

High-throughput

0.479

High

243955

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

243960

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

243965

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

243978

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

243989

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

243991

H2B1H
Histone H2B type 1-H

1

17

High-throughput

0.479

High

244005

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

8

Small-scale

0.479

High

244008

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.479

High

244010

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

244011

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

244012

ECT2
Protein ECT2

1

16

High-throughput

0.479

High

244018

ANLN
Anillin

1

5

High-throughput

0.479

High

244020

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

244023

PD1L1
Programmed cell death 1 ligand 1

1

6

Small-scale

0.479

High

244025

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

6

High-throughput

0.479

High

244028

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

244032

CD11A
Cyclin-dependent kinase 11A

1

14

High-throughput

0.479

High

244033

SMC3
Structural maintenance of chromosomes protein 3

1

17

High-throughput

0.479

High

244036

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

10

High-throughput

0.479

High

244038

NS1BP
Influenza virus NS1A-binding protein

1

4

High-throughput

0.479

High

243947

ZN239
Zinc finger protein 239

1

1

Small-scale

0.462

High

243956

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.458

High

243982

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

244022

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.458

High

212360

SPIT2
Kunitz-type protease inhibitor 2

1

2

High-throughput

0.445

High

243944

AAAT
Neutral amino acid transporter B(0)

1

2

High-throughput

0.445

High

243975

S15A4
Solute carrier family 15 member 4

1

2

High-throughput

0.445

High

243981

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

244019

S17A5
Sialin

1

1

High-throughput

0.445

High

243878

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.437

High

243898

MCM4
DNA replication licensing factor MCM4

1

15

High-throughput

0.437

High

243899

MCM7
DNA replication licensing factor MCM7

1

15

High-throughput

0.437

High

243963

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

243971

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.437

High

243987

TF3C2
General transcription factor 3C polypeptide 2

1

1

High-throughput

0.437

High

243994

ATG2B
Autophagy-related protein 2 homolog B

1

1

High-throughput

0.437

High

244014

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.437

High

244030

TF3C4
General transcription factor 3C polypeptide 4

1

1

High-throughput

0.437

High

183992

S22A1
Solute carrier family 22 member 1

1

1

High-throughput

0.407

High

243888

CD33
Myeloid cell surface antigen CD33

1

2

High-throughput

0.407

High

243892

ACKR3
Atypical chemokine receptor 3

1

3

High-throughput

0.407

High

243946

VACHT
Vesicular acetylcholine transporter

1

2

High-throughput

0.407

High

243949

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.407

High

243967

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

4

High-throughput

0.407

High

243968

STX12
Syntaxin-12

1

4

High-throughput

0.407

High

243972

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.407

High

243979

VGLU3
Vesicular glutamate transporter 3

1

1

High-throughput

0.407

High

243952

F219B
Protein FAM219B

3

0

High-throughput

0.347

High

243984

F174A
Membrane protein FAM174A

3

0

High-throughput

0.345

High

243948

TMM44
Transmembrane protein 44

2

0

High-throughput

0.328

High

243966

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

0

High-throughput

0.328

High

244007

MND1
Meiotic nuclear division protein 1 homolog

2

0

High-throughput

0.328

High

244027

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

0

High-throughput

0.328

High

223575

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

243870

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

243925

CD83
CD83 antigen

1

0

High-throughput

0.279

Low

243951

GSAML
Germinal center-associated signaling and motility-like protein

1

0

High-throughput

0.279

Low

243970

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.279

Low

243973

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

0

High-throughput

0.279

Low

243998

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.279

Low

61715

SBNO1
Protein strawberry notch homolog 1

1

0

High-throughput

0.249

Low

244017

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

244024

RELCH
RAB11-binding protein RELCH

1

0

High-throughput

0.249

Low

190286

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low

243891

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

Small-scale

0.232

Low

243969

SL9A9
Sodium/hydrogen exchanger 9

1

0

High-throughput

0.232

Low

243985

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.232

Low

244026

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025