Protein: ARHG7
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)

Gene: ARHG7, ARHGEF7
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q14155

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026158

PAK1
Serine/threonine-protein kinase PAK 1

18

19

Small-scale

0.988

High

1049747

GIT1
ARF GTPase-activating protein GIT1

13

20

Small-scale

0.982

High

1026904

PAK2
Serine/threonine-protein kinase PAK 2

7

19

Small-scale

0.970

High

1049703

SCRIB
Protein scribble homolog

8

4

Small-scale

0.964

High

1049704

GIT2
ARF GTPase-activating protein GIT2

6

20

Small-scale

0.950

High

1049706

ARHG6
Rho guanine nucleotide exchange factor 6

6

14

Small-scale

0.948

High

925271

RAC1
Ras-related C3 botulinum toxin substrate 1

6

20

Small-scale

0.939

High

893997

CDC42
Cell division control protein 42 homolog

5

20

Small-scale

0.930

High

209051

NCK2
Cytoplasmic protein NCK2

4

19

High-throughput

0.903

High

1049711

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

Small-scale

0.855

High

338419

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

1049728

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

18

Small-scale

0.843

High

557687

NCK1
SH2/SH3 adapter protein NCK1

3

20

High-throughput

0.839

High

1049744

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

2

20

Small-scale

0.815

High

1049709

KCC4
Calcium/calmodulin-dependent protein kinase type IV

2

8

High-throughput

0.811

High

1049739

SPN90
NCK-interacting protein with SH3 domain

2

3

High-throughput

0.811

High

277605

PAK3
Serine/threonine-protein kinase PAK 3

2

19

Small-scale

0.793

High

243141

SH21A
SH2 domain-containing protein 1A

2

20

Small-scale

0.781

High

1049725

SNX27
Sorting nexin-27

2

18

Small-scale

0.754

High

1049748

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

18

Small-scale

0.740

High

610397

CBL
E3 ubiquitin-protein ligase CBL

5

19

Small-scale

0.724

High

904551

1433G
14-3-3 protein gamma

5

20

High-throughput

0.712

High

158099

TX1B3
Tax1-binding protein 3

1

13

High-throughput

0.691

High

1049707

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

8

High-throughput

0.691

High

1049746

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

13

High-throughput

0.691

High

823391

PAXI
Paxillin

4

12

High-throughput

0.683

High

1049726

ERBIN
Erbin

1

2

Small-scale

0.681

High

1049723

ITCH
E3 ubiquitin-protein ligase Itchy homolog

3

4

Small-scale

0.680

High

1049702

ARHG7
Rho guanine nucleotide exchange factor 7

1

14

Small-scale

0.680

High

982002

1433F
14-3-3 protein eta

3

20

High-throughput

0.662

High

307173

KLHL2
Kelch-like protein 2

3

4

Small-scale

0.656

High

397161

KPCG
Protein kinase C gamma type

1

10

Small-scale

0.647

High

1049716

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

10

Small-scale

0.646

High

238961

LPXN
Leupaxin

2

13

High-throughput

0.628

High

400069

ICAM1
Intercellular adhesion molecule 1

2

3

High-throughput

0.628

High

928907

SKP1
S-phase kinase-associated protein 1

2

2

High-throughput

0.628

High

1049734

SYNCI
Syncoilin

2

7

High-throughput

0.628

High

1049737

EXOC1
Exocyst complex component 1

2

3

High-throughput

0.628

High

1037227

TBB3
Tubulin beta-3 chain

1

5

High-throughput

0.621

High

159209

CSKP
Peripheral plasma membrane protein CASK

1

13

Small-scale

0.618

High

279865

TRIO
Triple functional domain protein

1

16

High-throughput

0.618

High

325728

LATS1
Serine/threonine-protein kinase LATS1

1

9

Small-scale

0.618

High

384821

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

545368

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

564524

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

666108

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

892365

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

924563

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

1049713

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1049714

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1049720

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.618

High

1049724

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1049730

KPCD2
Serine/threonine-protein kinase D2

1

11

High-throughput

0.618

High

1049733

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1049710

INAVA
Innate immunity activator protein

2

0

High-throughput

0.602

High

1027604

CBLB
E3 ubiquitin-protein ligase CBL-B

2

18

Small-scale

0.596

High

381204

TBB4A
Tubulin beta-4A chain

1

5

High-throughput

0.590

High

1049735

MED4
Mediator of RNA polymerase II transcription subunit 4

2

2

High-throughput

0.580

High

1049738

FBX28
F-box only protein 28

2

1

High-throughput

0.574

High

497000

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.571

High

656596

PSB6
Proteasome subunit beta type-6

2

2

High-throughput

0.571

High

911834

RUXF
Small nuclear ribonucleoprotein F

2

3

High-throughput

0.571

High

837971

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.549

High

1049717

KAISO
Transcriptional regulator Kaiso

2

0

High-throughput

0.547

High

388435

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

843667

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.541

High

844057

FXR2
RNA-binding protein FXR2

1

6

High-throughput

0.541

High

245973

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.536

High

909551

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.536

High

1049721

REPS1
RalBP1-associated Eps domain-containing protein 1

1

18

High-throughput

0.536

High

1049736

KLHL1
Kelch-like protein 1

1

3

High-throughput

0.536

High

1049749

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

2

1

High-throughput

0.521

High

782239

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.515

High

173381

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

0

High-throughput

0.513

High

506236

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.513

High

664231

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.513

High

853598

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.513

High

1049715

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1049741

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.513

High

1049742

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

0

High-throughput

0.513

High

1049743

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.513

High

1049745

TPPC4
Trafficking protein particle complex subunit 4

1

0

High-throughput

0.513

High

1034750

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

7

Small-scale

0.512

High

829447

PPM1F
Protein phosphatase 1F

1

2

Small-scale

0.501

High

1049718

PPM1E
Protein phosphatase 1E

1

2

Small-scale

0.501

High

672119

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

Small-scale

0.500

High

1049731

CD244
Natural killer cell receptor 2B4

1

2

Small-scale

0.500

High

1049729

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

2

Small-scale

0.489

High

610160

RFX1
MHC class II regulatory factor RFX1

1

1

High-throughput

0.489

High

1049712

TM154
Transmembrane protein 154

1

1

High-throughput

0.489

High

1049750

NOX1
NADPH oxidase 1

1

0

Small-scale

0.480

High

227424

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

279549

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

538668

MYL6B
Myosin light chain 6B

1

2

High-throughput

0.479

High

779393

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

950178

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.479

High

1049705

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1049708

ZYX
Zyxin

1

12

High-throughput

0.479

High

1049719

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.479

High

1049740

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

771962

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

266151

ERLN1
Erlin-1

1

0

High-throughput

0.458

High

941656

IGBP1
Immunoglobulin-binding protein 1

1

0

Small-scale

0.458

High

708900

MCM7
DNA replication licensing factor MCM7

1

6

Small-scale

0.445

High

1049727

CK5P2
CDK5 regulatory subunit-associated protein 2

1

13

High-throughput

0.445

High

48870

POTB3
POTE ankyrin domain family member B3

1

13

High-throughput

0.407

High

89963

D6R9G5
Kelch like family member 2

1

5

High-throughput

0.407

High

126807

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.279

Low

199188

ZNHI1
Zinc finger HIT domain-containing protein 1

1

0

High-throughput

0.279

Low

1049732

ADSSP
Adipose-secreted signaling protein

1

0

High-throughput

0.279

Low

1049722

CERS2
Ceramide synthase 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024