Protein: PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase)

Gene: PLPP6
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q8IY26

Gene Ontology (top 5):
GO:0005637 - nuclear inner membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006695 - cholesterol biosynthetic process
GO:0006720 - isoprenoid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317111

AQP8
Aquaporin-8

2

1

High-throughput

0.606

High

338260

CLD9
Claudin-9

2

2

High-throughput

0.606

High

596950

PRLR
Prolactin receptor

2

1

High-throughput

0.606

High

1128918

I13R2
Interleukin-13 receptor subunit alpha-2

2

1

High-throughput

0.606

High

1228634

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

2

High-throughput

0.606

High

1249487

LAYN
Layilin

2

1

High-throughput

0.606

High

1249806

BTNL9
Butyrophilin-like protein 9

2

2

High-throughput

0.606

High

1270271

BT2A1
Butyrophilin subfamily 2 member A1

2

2

High-throughput

0.606

High

1313642

RNF5
E3 ubiquitin-protein ligase RNF5

2

2

High-throughput

0.606

High

284402

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

2

0

High-throughput

0.580

High

549819

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.580

High

580800

PVR
Poliovirus receptor

2

0

High-throughput

0.580

High

590307

MUC1
Mucin-1

2

0

High-throughput

0.580

High

593434

PGFRA
Platelet-derived growth factor receptor alpha

2

0

High-throughput

0.580

High

642252

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.580

High

1081319

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.580

High

1116635

I10R1
Interleukin-10 receptor subunit alpha

2

0

High-throughput

0.580

High

1132558

FXYD3
FXYD domain-containing ion transport regulator 3

2

0

High-throughput

0.580

High

1142874

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1159596

STX1A
Syntaxin-1A

2

0

High-throughput

0.580

High

1187398

SHSL1
Protein shisa-like-1

2

0

High-throughput

0.580

High

1207545

F209A
Protein FAM209A

2

0

High-throughput

0.580

High

1213646

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

2

0

High-throughput

0.580

High

1291416

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.580

High

1292530

AMGO1
Amphoterin-induced protein 1

2

0

High-throughput

0.580

High

1313619

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1313623

S7A14
Solute carrier family 7 member 14

2

0

High-throughput

0.580

High

1313624

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.580

High

1313626

F174A
Membrane protein FAM174A

2

0

High-throughput

0.580

High

1313627

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

1313629

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

1313632

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.580

High

1313635

MS4A3
Membrane-spanning 4-domains subfamily A member 3

2

0

High-throughput

0.580

High

1313637

RN170
E3 ubiquitin-protein ligase RNF170

2

0

High-throughput

0.580

High

1313638

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

1313640

FIMP
Fertilization-influencing membrane protein

2

0

High-throughput

0.580

High

1313641

SIG12
Sialic acid-binding Ig-like lectin 12

2

0

High-throughput

0.580

High

1313643

T106C
Transmembrane protein 106C

2

0

High-throughput

0.580

High

1313644

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

0

High-throughput

0.580

High

1313645

CLC4M
C-type lectin domain family 4 member M

2

0

High-throughput

0.580

High

1313647

VISTA
V-type immunoglobulin domain-containing suppressor of T-cell activation

2

0

High-throughput

0.580

High

1313649

TR10D
Tumor necrosis factor receptor superfamily member 10D

2

0

High-throughput

0.580

High

1108955

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

396473

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1313634

Q96FX9
Claudin

1

2

High-throughput

0.515

High

182647

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.513

High

1313628

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.513

High

942269

CLD15
Claudin-15

1

2

High-throughput

0.481

High

1313621

TMIE
Transmembrane inner ear expressed protein

1

0

High-throughput

0.460

High

623430

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

1113637

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1140532

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1139489

S39AE
Metal cation symporter ZIP14

1

2

High-throughput

0.445

High

1242851

S39A4
Zinc transporter ZIP4

1

2

High-throughput

0.445

High

1313631

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

564034

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

652212

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

0

High-throughput

0.426

High

844942

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.426

High

1271240

SV2B
Synaptic vesicle glycoprotein 2B

1

0

High-throughput

0.426

High

1313622

MFSD8
Major facilitator superfamily domain-containing protein 8

1

1

High-throughput

0.407

High

335253

CXB5
Gap junction beta-5 protein

2

0

High-throughput

0.316

High

1094851

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.316

High

1214408

GORAB
RAB6-interacting golgin

2

0

High-throughput

0.316

High

1313618

SYNE4
Nesprin-4

2

0

High-throughput

0.316

High

1313620

KASH5
Protein KASH5

2

0

High-throughput

0.316

High

1313625

SYNPR
Synaptoporin

2

0

High-throughput

0.316

High

1313639

PHAR3
Phosphatase and actin regulator 3

2

0

High-throughput

0.316

High

1313646

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

0

High-throughput

0.316

High

1313648

GKN1
Gastrokine-1

2

0

High-throughput

0.316

High

1313650

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

0

High-throughput

0.316

High

1313633

INT12
Integrator complex subunit 12

1

0

High-throughput

0.279

Low

1313630

SOCS4
Suppressor of cytokine signaling 4

1

0

High-throughput

0.251

Low

1313636

HSH2D
Hematopoietic SH2 domain-containing protein

1

0

High-throughput

0.251

Low

293989

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025