Protein: FNDC5
Fibronectin type III domain-containing protein 5 (Fibronectin type III repeat-containing protein 2) [Cleaved into: Irisin]

Gene: FNDC5
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q8NAU1

Gene Ontology (top 5):
GO:0005179 - hormone activity
GO:0005576 - extracellular region
GO:0005778 - peroxisomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

353442

PIGR
Polymeric immunoglobulin receptor

1

2

High-throughput

0.691

High

417060

CEAM5
Carcinoembryonic antigen-related cell adhesion molecule 5

1

3

High-throughput

0.691

High

434660

TSP1
Thrombospondin-1

1

6

High-throughput

0.691

High

533318

PLST
Plastin-3

1

2

High-throughput

0.691

High

592378

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.691

High

629157

ZA2G
Zinc-alpha-2-glycoprotein

1

2

High-throughput

0.691

High

895367

RAB5B
Ras-related protein Rab-5B

1

6

High-throughput

0.691

High

901598

LYSC
Lysozyme C

1

1

High-throughput

0.691

High

957551

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

4

High-throughput

0.691

High

363444

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.656

High

945699

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.656

High

300588

ENDD1
Endonuclease domain-containing 1 protein

2

1

High-throughput

0.628

High

586051

SL9A1
Sodium/hydrogen exchanger 1

2

2

High-throughput

0.628

High

750010

GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

2

2

High-throughput

0.628

High

1239227

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

2

2

High-throughput

0.628

High

82432

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

5

High-throughput

0.618

High

1239232

SLK
STE20-like serine/threonine-protein kinase

1

0

High-throughput

0.578

High

353541

IGKC
Immunoglobulin kappa constant

1

6

High-throughput

0.575

High

353702

IGHG1
Immunoglobulin heavy constant gamma 1

1

6

High-throughput

0.575

High

353797

IGHG2
Immunoglobulin heavy constant gamma 2

1

6

High-throughput

0.575

High

353972

IGHM
Immunoglobulin heavy constant mu

1

5

High-throughput

0.575

High

354096

IGHA1
Immunoglobulin heavy constant alpha 1

1

5

High-throughput

0.575

High

354175

IGHA2
Immunoglobulin heavy constant alpha 2

1

6

High-throughput

0.575

High

1239246

RHBD3
Rhomboid domain-containing protein 3

2

1

High-throughput

0.574

High

246591

MCE1
mRNA-capping enzyme

1

1

High-throughput

0.553

High

126533

QSOX1
Sulfhydryl oxidase 1

1

7

High-throughput

0.536

High

198455

KLK10
Kallikrein-10

1

8

High-throughput

0.536

High

224581

AK1BA
Aldo-keto reductase family 1 member B10

1

1

High-throughput

0.536

High

225108

TM11D
Transmembrane protease serine 11D

1

6

High-throughput

0.536

High

234250

PEPL
Periplakin

1

5

High-throughput

0.536

High

329838

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.536

High

341219

HPT
Haptoglobin

1

7

High-throughput

0.536

High

344211

A1AT
Alpha-1-antitrypsin

1

6

High-throughput

0.536

High

344691

CO3
Complement C3

1

3

High-throughput

0.536

High

362012

FIBG
Fibrinogen gamma chain

1

1

High-throughput

0.536

High

396765

S10A8
Protein S100-A8

1

7

High-throughput

0.536

High

397049

PAI2
Plasminogen activator inhibitor 2

1

6

High-throughput

0.536

High

416477

S10A9
Protein S100-A9

1

7

High-throughput

0.536

High

473781

PA24B
Cytosolic phospholipase A2 beta

1

1

High-throughput

0.536

High

533980

ANXA8
Annexin A8

1

1

High-throughput

0.536

High

596848

ENDOU
Uridylate-specific endoribonuclease

1

1

High-throughput

0.536

High

611288

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

4

High-throughput

0.536

High

648826

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.536

High

667997

SPB3
Serpin B3

1

6

High-throughput

0.536

High

676755

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

4

High-throughput

0.536

High

701689

DSG3
Desmoglein-3

1

3

High-throughput

0.536

High

820343

SPB4
Serpin B4

1

6

High-throughput

0.536

High

945861

NUCB2
Nucleobindin-2

1

2

High-throughput

0.536

High

971039

DSC2
Desmocollin-2

1

2

High-throughput

0.536

High

990554

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.536

High

1045981

PKP1
Plakophilin-1

1

2

High-throughput

0.536

High

1085210

PRSS8
Prostasin

1

5

High-throughput

0.536

High

1167714

RPTN
Repetin

1

6

High-throughput

0.536

High

1233586

BPIB2
BPI fold-containing family B member 2

1

1

High-throughput

0.536

High

1239221

MUC7
Mucin-7

1

2

High-throughput

0.536

High

1239222

BPIB1
BPI fold-containing family B member 1

1

2

High-throughput

0.536

High

1239223

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

1

High-throughput

0.536

High

1239229

CPNS2
Calpain small subunit 2

1

2

High-throughput

0.536

High

1239230

SPB12
Serpin B12

1

7

High-throughput

0.536

High

1239231

NIBA2
Protein Niban 2

1

1

High-throughput

0.536

High

1239234

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

1

High-throughput

0.536

High

1239235

MUC5B
Mucin-5B

1

4

High-throughput

0.536

High

1239236

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.536

High

1239238

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.536

High

1239239

KLK14
Kallikrein-14

1

7

High-throughput

0.536

High

1239242

DMBT1
Deleted in malignant brain tumors 1 protein

1

6

High-throughput

0.536

High

1239244

KLK13
Kallikrein-13

1

7

High-throughput

0.536

High

1239247

PKP3
Plakophilin-3

1

2

High-throughput

0.536

High

120088

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

135739

EST2
Cocaine esterase

1

0

High-throughput

0.513

High

333638

ADH1G
Alcohol dehydrogenase 1C

1

0

High-throughput

0.513

High

353135

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.513

High

361368

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

364706

TRFL
Lactotransferrin

1

0

High-throughput

0.513

High

365316

STAT
Statherin

1

0

High-throughput

0.513

High

441026

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

519039

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

577492

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.513

High

589119

TCO1
Transcobalamin-1

1

0

High-throughput

0.513

High

873561

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.513

High

1239225

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.513

High

1239228

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

172756

ZN185
Zinc finger protein 185

1

1

High-throughput

0.489

High

259866

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.489

High

260942

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.489

High

306588

SCEL
Sciellin

1

1

High-throughput

0.489

High

334359

AL1A1
Aldehyde dehydrogenase 1A1

1

2

High-throughput

0.489

High

428604

INVO
Involucrin

1

4

High-throughput

0.489

High

556639

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.489

High

596302

FILA
Filaggrin

1

8

High-throughput

0.489

High

661350

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

814995

LEG7
Galectin-7

1

1

High-throughput

0.489

High

822489

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.489

High

839498

SPB8
Serpin B8

1

6

High-throughput

0.489

High

981208

AK1C1
Aldo-keto reductase family 1 member C1

1

1

High-throughput

0.489

High

993039

RHG01
Rho GTPase-activating protein 1

1

1

High-throughput

0.489

High

993977

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

4

High-throughput

0.489

High

1048763

TRI29
Tripartite motif-containing protein 29

1

1

High-throughput

0.489

High

1165461

SBSN
Suprabasin

1

1

High-throughput

0.489

High

1169148

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.489

High

1239220

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

3

High-throughput

0.489

High

1239226

EVPL
Envoplakin

1

4

High-throughput

0.489

High

1239233

GHITM
Growth hormone-inducible transmembrane protein

1

2

High-throughput

0.489

High

1239240

SPRR3
Small proline-rich protein 3

1

1

High-throughput

0.489

High

1239241

CRNN
Cornulin

1

7

High-throughput

0.489

High

1239243

SPB13
Serpin B13

1

6

High-throughput

0.489

High

957258

MUC5A
Mucin-5AC

1

3

High-throughput

0.445

High

72318

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

66417

A2ML1
Alpha-2-macroglobulin-like protein 1

1

3

High-throughput

0.407

High

484844

AMY1B
Alpha-amylase 1B

1

1

High-throughput

0.407

High

275504

CAN15
Calpain-15

2

0

High-throughput

0.328

High

1165256

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.328

High

325536

CLIC3
Chloride intracellular channel protein 3

1

0

High-throughput

0.279

Low

648554

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

970633

SEMG2
Semenogelin-2

1

0

High-throughput

0.279

Low

1087055

H2A2C
Histone H2A type 2-C

1

0

High-throughput

0.279

Low

1088102

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.279

Low

1121820

APRV1
Retroviral-like aspartic protease 1

1

0

High-throughput

0.279

Low

1128996

SAMD9
Sterile alpha motif domain-containing protein 9

1

0

High-throughput

0.279

Low

1138838

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.279

Low

1160095

LEG1H
Protein LEG1 homolog

1

0

High-throughput

0.279

Low

1173079

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

1239224

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

1239237

GLTP
Glycolipid transfer protein

1

0

High-throughput

0.279

Low

1239245

NDRG2
Protein NDRG2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024