Protein: CTLA4
Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)

Gene: CTLA4
Organism: Homo sapiens
Interactions: 132
UniProt ID: P16410

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

596458

CD80
T-lymphocyte activation antigen CD80

4

9

Small-scale

0.906

High

596462

CD86
T-lymphocyte activation antigen CD86

2

7

Small-scale

0.817

High

596478

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

4

High-throughput

0.776

High

333440

MPZL1
Myelin protein zero-like protein 1

1

1

High-throughput

0.691

High

532040

KIT
Mast/stem cell growth factor receptor Kit

1

1

High-throughput

0.691

High

596452

INAR1
Interferon alpha/beta receptor 1

1

5

High-throughput

0.691

High

596455

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.691

High

596461

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

1

High-throughput

0.691

High

596466

BCAM
Basal cell adhesion molecule

1

1

High-throughput

0.691

High

596467

EPHA4
Ephrin type-A receptor 4

1

2

High-throughput

0.691

High

596474

I10R2
Interleukin-10 receptor subunit beta

1

2

High-throughput

0.691

High

596486

CDON
Cell adhesion molecule-related/down-regulated by oncogenes

1

2

High-throughput

0.691

High

596488

SDK2
Protein sidekick-2

1

3

High-throughput

0.691

High

596498

LRP10
Low-density lipoprotein receptor-related protein 10

1

1

High-throughput

0.691

High

596512

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

2

High-throughput

0.691

High

596513

NEO1
Neogenin

1

3

High-throughput

0.691

High

596514

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.691

High

596547

JAG2
Protein jagged-2

1

1

High-throughput

0.691

High

596550

LRP12
Low-density lipoprotein receptor-related protein 12

1

2

High-throughput

0.691

High

596553

ROBO1
Roundabout homolog 1

1

3

High-throughput

0.691

High

596516

AP2M1
AP-2 complex subunit mu

4

1

Small-scale

0.688

High

596465

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

3

1

Small-scale

0.657

High

164241

NRP1
Neuropilin-1

1

0

High-throughput

0.656

High

296902

DGAT1
Diacylglycerol O-acyltransferase 1

1

0

High-throughput

0.656

High

507068

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.656

High

596459

ABCD1
ATP-binding cassette sub-family D member 1

1

0

High-throughput

0.656

High

596460

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.656

High

596464

S26A2
Sulfate transporter

1

0

High-throughput

0.656

High

596468

MFAP3
Microfibril-associated glycoprotein 3

1

0

High-throughput

0.656

High

596489

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

1

0

High-throughput

0.656

High

596511

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.656

High

596517

RB39B
Ras-related protein Rab-39B

1

0

High-throughput

0.656

High

596529

ULBP3
UL16-binding protein 3

1

0

High-throughput

0.656

High

596541

PD1L1
Programmed cell death 1 ligand 1

1

8

Small-scale

0.618

High

596457

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

5

Small-scale

0.611

High

596525

TACAN
Transmembrane protein 120A

2

1

High-throughput

0.601

High

596481

RPGF1
Rap guanine nucleotide exchange factor 1

1

0

Small-scale

0.586

High

596477

MALL
MAL-like protein

2

0

High-throughput

0.580

High

228060

PM34
Peroxisomal membrane protein PMP34

1

0

High-throughput

0.578

High

284924

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

0

High-throughput

0.578

High

596531

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.578

High

212053

B4GT5
Beta-1,4-galactosyltransferase 5

2

0

High-throughput

0.576

High

596532

GO45
Golgin-45

2

0

High-throughput

0.576

High

522587

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

3

High-throughput

0.575

High

532158

CD28
T-cell-specific surface glycoprotein CD28

1

2

High-throughput

0.575

High

596451

CTLA4
Cytotoxic T-lymphocyte protein 4

1

2

Small-scale

0.575

High

596479

BT1A1
Butyrophilin subfamily 1 member A1

1

1

High-throughput

0.575

High

596523

OSMR
Oncostatin-M-specific receptor subunit beta

1

5

High-throughput

0.575

High

596507

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

0

High-throughput

0.546

High

596528

RAB34
Ras-related protein Rab-34

1

0

High-throughput

0.546

High

596530

TOLIP
Toll-interacting protein

1

0

High-throughput

0.546

High

596546

PCDGK
Protocadherin gamma-C3

1

0

High-throughput

0.546

High

596551

AGRG1
Adhesion G-protein coupled receptor G1

1

0

High-throughput

0.546

High

596453

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

3

High-throughput

0.536

High

596470

I13R1
Interleukin-13 receptor subunit alpha-1

1

5

High-throughput

0.536

High

596471

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

596535

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

1

High-throughput

0.536

High

596483

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.529

High

136473

GOLI4
Golgi integral membrane protein 4

1

0

High-throughput

0.513

High

220114

SGCE
Epsilon-sarcoglycan

1

0

High-throughput

0.513

High

331836

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.513

High

596454

FUT4
Alpha-(1,3)-fucosyltransferase 4

1

0

High-throughput

0.513

High

596475

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.513

High

596485

OCLN
Occludin

1

0

High-throughput

0.513

High

596505

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

596506

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.513

High

596522

MYADM
Myeloid-associated differentiation marker

1

0

High-throughput

0.513

High

596527

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.513

High

596537

ZDH18
Palmitoyltransferase ZDHHC18

1

0

High-throughput

0.513

High

596539

S39A1
Zinc transporter ZIP1

1

0

High-throughput

0.513

High

596540

PDXL2
Podocalyxin-like protein 2

1

0

High-throughput

0.513

High

596542

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.513

High

596544

VANG2
Vang-like protein 2

1

0

High-throughput

0.513

High

49623

T120B
Transmembrane protein 120B

1

1

High-throughput

0.489

High

169425

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.489

High

290234

TM1L1
TOM1-like protein 1

1

2

High-throughput

0.489

High

596519

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.489

High

596538

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

1

High-throughput

0.489

High

430576

FABPH
Fatty acid-binding protein, heart

1

0

High-throughput

0.481

High

596490

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

0

High-throughput

0.481

High

596495

LRRN1
Leucine-rich repeat neuronal protein 1

1

0

High-throughput

0.481

High

596496

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

0

High-throughput

0.481

High

253288

JAK2
Tyrosine-protein kinase JAK2

1

5

Small-scale

0.479

High

439938

LCK
Tyrosine-protein kinase Lck

1

3

Small-scale

0.479

High

440343

FYN
Tyrosine-protein kinase Fyn

1

3

Small-scale

0.479

High

463318

LYN
Tyrosine-protein kinase Lyn

1

3

Small-scale

0.479

High

596456

JAK1
Tyrosine-protein kinase JAK1

1

6

High-throughput

0.445

High

596508

NBEA
Neurobeachin

1

1

High-throughput

0.445

High

596536

TEN2
Teneurin-2

1

2

High-throughput

0.445

High

216315

MGA
Maltase-glucoamylase

1

0

High-throughput

0.426

High

596526

TMM59
Transmembrane protein 59

1

0

High-throughput

0.426

High

596545

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.426

High

596548

MYRF
Myelin regulatory factor

1

0

High-throughput

0.426

High

596497

TM1L2
TOM1-like protein 2

1

2

High-throughput

0.407

High

60554

TM218
Transmembrane protein 218

2

0

High-throughput

0.316

High

596487

CTXN3
Cortexin-3

2

0

High-throughput

0.316

High

596473

FOXM1
Forkhead box protein M1

2

0

High-throughput

0.313

High

596549

MAN1
Inner nuclear membrane protein Man1

2

0

High-throughput

0.313

High

67060

CO061
Uncharacterized protein C15orf61

1

0

High-throughput

0.279

Low

175495

KHNYN
Protein KHNYN

1

0

High-throughput

0.279

Low

294773

CAN15
Calpain-15

1

0

High-throughput

0.279

Low

319135

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.279

Low

596469

NOP14
Nucleolar protein 14

1

0

High-throughput

0.279

Low

596472

UBXN1
UBX domain-containing protein 1

1

0

High-throughput

0.279

Low

596476

DYH14
Dynein axonemal heavy chain 14

1

0

High-throughput

0.279

Low

596480

PEX6
Peroxisomal ATPase PEX6

1

0

High-throughput

0.279

Low

596482

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.279

Low

596484

ELF2
ETS-related transcription factor Elf-2

1

0

High-throughput

0.279

Low

596491

DEP1A
DEP domain-containing protein 1A

1

0

High-throughput

0.279

Low

596492

LTMD1
LETM1 domain-containing protein 1

1

0

High-throughput

0.279

Low

596493

NFRKB
Nuclear factor related to kappa-B-binding protein

1

0

High-throughput

0.279

Low

596499

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

High-throughput

0.279

Low

596500

DEN6A
Protein DENND6A

1

0

High-throughput

0.279

Low

596501

MGAP
MAX gene-associated protein

1

0

High-throughput

0.279

Low

596502

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

0

High-throughput

0.279

Low

596503

RBFA
Putative ribosome-binding factor A, mitochondrial

1

0

High-throughput

0.279

Low

596504

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

1

0

High-throughput

0.279

Low

596509

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

596510

S35F5
Solute carrier family 35 member F5

1

0

High-throughput

0.279

Low

596515

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.279

Low

596518

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.279

Low

596520

P121A
Nuclear envelope pore membrane protein POM 121

1

0

High-throughput

0.279

Low

596521

FACR2
Fatty acyl-CoA reductase 2

1

0

High-throughput

0.279

Low

596524

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.279

Low

596533

CUED2
CUE domain-containing protein 2

1

0

High-throughput

0.279

Low

596534

NSUN3
tRNA

1

0

High-throughput

0.279

Low

596543

PKHB1
Pleckstrin homology domain-containing family B member 1

1

0

High-throughput

0.279

Low

596552

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.279

Low

596463

STA5A
Signal transducer and activator of transcription 5A

1

0

Small-scale

0.238

Low

403799

GCR
Glucocorticoid receptor

1

0

High-throughput

0.232

Low

596494

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025