Protein: BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)

Gene: BUB1B
Organism: Homo sapiens
Interactions: 165
UniProt ID: O60566

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

224189

BUB3
Mitotic checkpoint protein BUB3

32

16

Small-scale

0.994

High

251820

APC4
Anaphase-promoting complex subunit 4

19

2

Small-scale

0.986

High

224061

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

8

20

Small-scale

0.968

High

251821

ANC2
Anaphase-promoting complex subunit 2

5

16

High-throughput

0.932

High

251741

RAE1L
mRNA export factor RAE1

3

14

High-throughput

0.861

High

251683

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

3

19

Small-scale

0.839

High

251747

CDC20
Cell division cycle protein 20 homolog

68

20

Small-scale

0.773

High

251713

CDC27
Cell division cycle protein 27 homolog

25

17

Small-scale

0.767

High

251750

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

23

10

Small-scale

0.767

High

251728

PLK1
Serine/threonine-protein kinase PLK1

7

19

Small-scale

0.745

High

251748

CDC16
Cell division cycle protein 16 homolog

7

18

Small-scale

0.744

High

251818

APC7
Anaphase-promoting complex subunit 7

7

18

Small-scale

0.741

High

251817

CDC23
Cell division cycle protein 23 homolog

6

18

Small-scale

0.735

High

251785

KNL1
Outer kinetochore KNL1 complex subunit KNL1

5

1

Small-scale

0.733

High

251686

UBR5
E3 ubiquitin-protein ligase UBR5

6

20

Small-scale

0.726

High

251808

APC1
Anaphase-promoting complex subunit 1

4

2

Small-scale

0.691

High

251824

FZR1
Fizzy-related protein homolog

4

20

Small-scale

0.680

High

251763

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

3

7

Small-scale

0.679

High

251806

MIS12
Protein MIS12 homolog

3

1

Small-scale

0.662

High

251743

CENPE
Centromere-associated protein E

3

3

Small-scale

0.660

High

251795

APC16
Anaphase-promoting complex subunit 16

4

0

High-throughput

0.658

High

251753

HDAC1
Histone deacetylase 1

3

13

Small-scale

0.656

High

251723

MXI1
Max-interacting protein 1

3

16

Small-scale

0.640

High

251688

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.628

High

251793

KAT2B
Histone acetyltransferase KAT2B

2

7

Small-scale

0.628

High

251725

BRCA2
Breast cancer type 2 susceptibility protein

3

0

Small-scale

0.625

High

251777

WDR74
WD repeat-containing protein 74

1

11

High-throughput

0.618

High

251828

FBW1A
F-box/WD repeat-containing protein 1A

1

10

High-throughput

0.618

High

251786

CDC26
Anaphase-promoting complex subunit CDC26

3

0

High-throughput

0.616

High

251761

MD2BP
MAD2L1-binding protein

3

0

Small-scale

0.613

High

251774

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

0

High-throughput

0.602

High

251819

APC5
Anaphase-promoting complex subunit 5

2

1

High-throughput

0.601

High

251766

PCH2
Pachytene checkpoint protein 2 homolog

2

15

Small-scale

0.595

High

188122

HDAC3
Histone deacetylase 3

2

11

Small-scale

0.584

High

251697

PARP1
Poly [ADP-ribose] polymerase 1

2

8

Small-scale

0.584

High

251739

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

20

Small-scale

0.584

High

251791

HDAC2
Histone deacetylase 2

2

13

Small-scale

0.584

High

251797

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.578

High

251684

SYUG
Gamma-synuclein

1

4

Small-scale

0.573

High

186672

P73
Tumor protein p73

1

5

Small-scale

0.561

High

251689

PTTG1
Securin

1

2

Small-scale

0.561

High

251810

PLK3
Serine/threonine-protein kinase PLK3

1

19

Small-scale

0.561

High

251751

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

7

Small-scale

0.552

High

163866

NDC80
Kinetochore protein NDC80 homolog

1

15

High-throughput

0.536

High

251691

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.536

High

251694

HSPB1
Heat shock protein beta-1

1

10

High-throughput

0.536

High

251702

EF2
Elongation factor 2

1

4

High-throughput

0.536

High

251707

PSA3
Proteasome subunit alpha type-3

1

5

High-throughput

0.536

High

251708

PSA4
Proteasome subunit alpha type-4

1

6

High-throughput

0.536

High

251711

PSB5
Proteasome subunit beta type-5

1

8

High-throughput

0.536

High

251712

SPB3
Serpin B3

1

4

High-throughput

0.536

High

251714

KPYR
Pyruvate kinase PKLR

1

1

High-throughput

0.536

High

251716

S10AB
Protein S100-A11

1

8

High-throughput

0.536

High

251719

MTREX
Exosome RNA helicase MTR4

1

4

High-throughput

0.536

High

251721

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

251729

MK12
Mitogen-activated protein kinase 12

1

17

High-throughput

0.536

High

251730

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

251733

PSA6
Proteasome subunit alpha type-6

1

8

High-throughput

0.536

High

251740

TCPB
T-complex protein 1 subunit beta

1

14

High-throughput

0.536

High

251749

RM28
Large ribosomal subunit protein bL28m

1

1

High-throughput

0.536

High

251754

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

251760

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

2

High-throughput

0.536

High

251776

PMF1
Polyamine-modulated factor 1

1

1

High-throughput

0.536

High

251783

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

7

Small-scale

0.536

High

251789

HS105
Heat shock protein 105 kDa

1

13

High-throughput

0.536

High

251790

GCN1
Stalled ribosome sensor GCN1

1

10

High-throughput

0.536

High

251796

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

6

High-throughput

0.536

High

251801

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

251804

NUF2
Kinetochore protein Nuf2

1

9

High-throughput

0.536

High

251809

DSN1
Kinetochore-associated protein DSN1 homolog

1

1

High-throughput

0.536

High

251737

AP2B1
AP-2 complex subunit beta

1

11

Small-scale

0.527

High

251807

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.518

High

155055

SOCS2
Suppressor of cytokine signaling 2

1

20

High-throughput

0.515

High

163668

TCRG1
Transcription elongation regulator 1

1

5

High-throughput

0.515

High

251687

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

2

High-throughput

0.515

High

251744

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.515

High

212863

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.513

High

244622

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.513

High

251696

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

251720

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

251732

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

251773

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

251788

CERK1
Ceramide kinase

1

0

High-throughput

0.513

High

251778

DNMBP
Dynamin-binding protein

1

16

High-throughput

0.508

High

251704

CCNA2
Cyclin-A2

1

6

Small-scale

0.501

High

251706

APC
Adenomatous polyposis coli protein

1

7

Small-scale

0.501

High

251829

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

251830

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

Small-scale

0.501

High

251816

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.493

High

251690

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.489

High

251698

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

1

High-throughput

0.489

High

251718

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

3

High-throughput

0.489

High

251765

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.489

High

251805

SEM4C
Semaphorin-4C

1

1

High-throughput

0.489

High

251757

DHX8
ATP-dependent RNA helicase DHX8

1

3

Small-scale

0.481

High

251759

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

7

Small-scale

0.481

High

251764

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

7

Small-scale

0.481

High

251768

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

7

Small-scale

0.481

High

172310

XPO1
Exportin-1

1

11

High-throughput

0.479

High

246324

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

247186

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

16

High-throughput

0.479

High

251685

TRI37
E3 ubiquitin-protein ligase TRIM37

1

17

High-throughput

0.479

High

251693

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

251695

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

251699

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.479

High

251700

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

251701

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

251703

VINC
Vinculin

1

10

High-throughput

0.479

High

251705

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

251709

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

251710

CALR
Calreticulin

1

1

High-throughput

0.479

High

251715

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

251722

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

251724

VASP
Vasodilator-stimulated phosphoprotein

1

7

High-throughput

0.479

High

251727

NEK2
Serine/threonine-protein kinase Nek2

1

19

Small-scale

0.479

High

251731

HDAC4
Histone deacetylase 4

1

18

Small-scale

0.479

High

251734

1433E
14-3-3 protein epsilon

1

12

High-throughput

0.479

High

251735

RL39
Large ribosomal subunit protein eL39

1

3

High-throughput

0.479

High

251736

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

251738

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.479

High

251742

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

251745

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.479

High

251752

SQSTM
Sequestosome-1

1

8

High-throughput

0.479

High

251755

CUL3
Cullin-3

1

12

High-throughput

0.479

High

251756

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

19

High-throughput

0.479

High

251758

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

15

High-throughput

0.479

High

251767

ZYX
Zyxin

1

8

High-throughput

0.479

High

251772

DAB2P
Disabled homolog 2-interacting protein

1

20

Small-scale

0.479

High

251779

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

251780

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

251781

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

251784

NKAP
NF-kappa-B-activating protein

1

2

Small-scale

0.479

High

251792

KAT2A
Histone acetyltransferase KAT2A

1

12

Small-scale

0.479

High

251798

AURKB
Aurora kinase B

1

17

Small-scale

0.479

High

251799

AJUBA
LIM domain-containing protein ajuba

1

8

Small-scale

0.479

High

251802

DNJC7
DnaJ homolog subfamily C member 7

1

17

High-throughput

0.479

High

251811

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

251812

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

251814

FBX6
F-box only protein 6

1

1

Small-scale

0.479

High

251822

RCOR1
REST corepressor 1

1

7

High-throughput

0.479

High

251823

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.479

High

251825

APC10
Anaphase-promoting complex subunit 10

1

5

Small-scale

0.479

High

251826

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

Small-scale

0.479

High

251827

HDAC5
Histone deacetylase 5

1

18

Small-scale

0.479

High

251832

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

3

High-throughput

0.479

High

251803

HOP
Homeodomain-only protein

1

0

Small-scale

0.460

High

251771

SGO1
Shugoshin 1

1

0

Small-scale

0.458

High

251800

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.458

High

251813

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

251815

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

251746

AP1B1
AP-1 complex subunit beta-1

1

11

Small-scale

0.457

High

251831

AP4B1
AP-4 complex subunit beta-1

1

12

Small-scale

0.457

High

251717

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

251794

PF21A
PHD finger protein 21A

1

5

High-throughput

0.437

High

126030

AP3B1
AP-3 complex subunit beta-1

1

11

Small-scale

0.417

High

251770

R39L5
Putative ribosomal protein eL39-like 5

1

3

High-throughput

0.407

High

251775

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

1

Small-scale

0.407

High

251692

STAT
Statherin

1

0

High-throughput

0.279

Low

251762

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

251769

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.279

Low

251782

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

251787

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

67057

CO061
Uncharacterized protein C15orf61

1

0

High-throughput

0.249

Low

251726

GPC3
Glypican-3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025