HitPredict - High confidence protein-protein interactions

Interactor 1: HSP90 (Q18688)
Heat shock protein 90 (Abnormal dauer formation protein 21)
Gene: hsp-90

Interactor 2: HSP90 (Q18688)
Heat shock protein 90 (Abnormal dauer formation protein 21)
Gene: hsp-90

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	14992718, 18692475, unassigned701
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HATPase_c_3~HATPase_c_3, HATPase_c_3~HSP90, HSP90~HSP90
Common GO terms	GO:0002119 - nematode larval development GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 22 others more... GO:0006457 - protein folding GO:0006611 - protein export from nucleus GO:0006935 - chemotaxis GO:0008287 - protein serine/threonine phosphatase complex GO:0008340 - determination of adult lifespan GO:0009408 - response to heat GO:0016887 - ATP hydrolysis activity GO:0032991 - protein-containing complex GO:0034605 - cellular response to heat GO:0035259 - nuclear glucocorticoid receptor binding GO:0040024 - dauer larval development GO:0045121 - membrane raft GO:0048471 - perinuclear region of cytoplasm GO:0050821 - protein stabilization GO:0050829 - defense response to Gram-negative bacterium GO:0050920 - regulation of chemotaxis GO:0051082 - unfolded protein binding GO:0072542 - protein phosphatase activator activity GO:0101031 - protein folding chaperone complex GO:0140662 - ATP-dependent protein folding chaperone GO:1990565 - HSP90-CDC37 chaperone complex GO:1990634 - protein phosphatase 5 binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	702
Ce

1	702

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Last updated: 11Aug2025