Protein: MCM5
Minichromosome maintenance protein 5 (EC 3.6.4.12) (Cell division control protein 46)

Gene: MCM5
Organism: Saccharomyces cerevisiae S288C
Interactions: 129
UniProt ID: P29496

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622146

MCM3
DNA replication licensing factor MCM3

23

20

Small-scale

0.989

High

667899

CDC45
Cell division control protein 45

17

17

Small-scale

0.983

High

667884

SLD5
DNA replication complex GINS protein SLD5

16

15

Small-scale

0.983

High

667834

MCM4
DNA replication licensing factor MCM4

16

19

Small-scale

0.980

High

667546

MCM2
DNA replication licensing factor MCM2

14

20

Small-scale

0.979

High

667852

MCM7
DNA replication licensing factor MCM7

10

19

Small-scale

0.971

High

667872

MCM6
DNA replication licensing factor MCM6

8

19

Small-scale

0.956

High

667868

CDT1
Cell division cycle protein CDT1

5

3

Small-scale

0.922

High

667859

PSF2
DNA replication complex GINS protein PSF2

4

12

Small-scale

0.878

High

667901

PSF3
DNA replication complex GINS protein PSF3

4

10

Small-scale

0.878

High

667904

PSF1
DNA replication complex GINS protein PSF1

4

12

Small-scale

0.878

High

667833

MCM5
Minichromosome maintenance protein 5

2

19

High-throughput

0.737

High

667882

CTF4
DNA polymerase alpha-binding protein

7

9

Small-scale

0.736

High

667837

MCM10
Minichromosome maintenance protein 10

6

13

Small-scale

0.734

High

667876

TOF1
Topoisomerase 1-associated factor 1

5

8

Small-scale

0.709

High

667873

SLD3
DNA replication regulator SLD3

3

3

Small-scale

0.655

High

667839

SPT16
FACT complex subunit SPT16

3

5

Small-scale

0.633

High

412530

CDC7
Cell division control protein 7

2

20

Small-scale

0.625

High

356303

H4
Histone H4

3

8

High-throughput

0.624

High

493390

HSP72
Heat shock protein SSA2

3

16

High-throughput

0.624

High

667870

ORC5
Origin recognition complex subunit 5

1

6

Small-scale

0.618

High

526828

DPOLA
DNA polymerase alpha catalytic subunit A

2

10

Small-scale

0.611

High

667900

DIA2
Protein DIA2

2

3

Small-scale

0.611

High

510521

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.601

High

602322

DPOE
DNA polymerase epsilon catalytic subunit A

2

10

Small-scale

0.585

High

392334

H2A2
Histone H2A.2

2

20

High-throughput

0.571

High

622863

DPB2
DNA polymerase epsilon subunit B

2

4

Small-scale

0.571

High

634862

MRC1
Mediator of replication checkpoint protein 1

2

3

Small-scale

0.571

High

667858

ATAD2
ATPase histone chaperone YTA7

2

3

High-throughput

0.571

High

667891

POB3
FACT complex subunit POB3

2

9

High-throughput

0.571

High

667853

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

2

4

High-throughput

0.552

High

667860

SA185
SIT4-associating protein SAP185

2

0

High-throughput

0.547

High

446124

MYO1
Myosin-1

1

8

High-throughput

0.536

High

585269

MYO2
Myosin-2

1

6

High-throughput

0.536

High

605932

RAD53
Serine/threonine-protein kinase RAD53

1

9

High-throughput

0.536

High

667838

MYO4
Myosin-4

1

6

High-throughput

0.536

High

667878

ACT
Actin

1

8

High-throughput

0.536

High

667889

MYO5
Myosin-5

1

10

High-throughput

0.536

High

667863

RSC8
Chromatin structure-remodeling complex protein RSC8

2

0

High-throughput

0.528

High

667903

SMT3
Ubiquitin-like protein SMT3

1

6

Small-scale

0.515

High

667845

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

High-throughput

0.513

High

667850

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.513

High

667854

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.513

High

667888

GYL1
Probable GTPase-activating protein GYL1

1

0

High-throughput

0.513

High

565490

PHO85
Cyclin-dependent protein kinase PHO85

1

9

High-throughput

0.501

High

648109

KCC1
Calcium/calmodulin-dependent protein kinase I

1

4

High-throughput

0.501

High

667835

DBF4
DDK kinase regulatory subunit DBF4

1

3

Small-scale

0.501

High

667840

IME2
Meiosis induction protein kinase IME2/SME1

1

13

Small-scale

0.501

High

667842

ORC2
Origin recognition complex subunit 2

1

6

Small-scale

0.501

High

667847

SLD2
DNA replication regulator SLD2

1

3

Small-scale

0.501

High

667865

DPB11
DNA replication regulator DPB11

1

2

Small-scale

0.501

High

667877

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.501

High

528314

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.489

High

659107

CAPZA
F-actin-capping protein subunit alpha

1

2

High-throughput

0.489

High

667864

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.489

High

667874

MLC1
Myosin light chain 1

1

1

High-throughput

0.489

High

667895

CORO
Coronin-like protein

1

2

High-throughput

0.489

High

416200

SIR2
NAD-dependent histone deacetylase SIR2

1

13

Small-scale

0.481

High

607223

RFA1
Replication factor A protein 1

1

7

Small-scale

0.481

High

340058

KPYK1
Pyruvate kinase 1

1

5

High-throughput

0.479

High

410939

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

420093

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.479

High

447786

CDC6
Cell division control protein 6

1

19

Small-scale

0.479

High

560921

EF3A
Elongation factor 3A

1

6

High-throughput

0.479

High

587979

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.479

High

649862

CDC15
Cell division control protein 15

1

2

High-throughput

0.479

High

661543

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

667843

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

667848

SPT10
Protein SPT10

1

3

High-throughput

0.479

High

667849

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

667871

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

667880

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

667887

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

667892

CSM3
Chromosome segregation in meiosis protein 3

1

3

Small-scale

0.479

High

667894

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

667897

NOC3
Nucleolar complex-associated protein 3

1

2

Small-scale

0.479

High

667902

SCC1
Sister chromatid cohesion protein 1

1

3

High-throughput

0.479

High

557931

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

667836

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

667844

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

667867

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

355383

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

355816

H2B2
Histone H2B.2

1

20

High-throughput

0.445

High

360781

TBB
Tubulin beta chain

1

14

High-throughput

0.445

High

367820

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

399362

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

419314

HAP2
Transcriptional activator HAP2

1

3

High-throughput

0.445

High

424384

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.445

High

454222

TBA1
Tubulin alpha-1 chain

1

8

High-throughput

0.445

High

490561

HSP71
Heat shock protein SSA1

1

16

High-throughput

0.445

High

515043

MCM1
Pheromone receptor transcription factor

1

1

High-throughput

0.445

High

516280

RAP1
DNA-binding protein RAP1

1

1

High-throughput

0.445

High

555870

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.445

High

562195

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

4

High-throughput

0.445

High

566542

VATA
V-type proton ATPase catalytic subunit A

1

7

High-throughput

0.445

High

599427

VPS1
Vacuolar protein sorting-associated protein 1

1

1

High-throughput

0.445

High

605212

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

609052

SIN3
Transcriptional regulatory protein SIN3

1

1

High-throughput

0.445

High

628843

SWI4
Regulatory protein SWI4

1

8

High-throughput

0.445

High

646631

DPB3
DNA polymerase epsilon subunit C

1

1

Small-scale

0.445

High

667841

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

667846

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

667851

SET3
SET domain-containing protein 3

1

5

High-throughput

0.445

High

667855

IMB4
Importin subunit beta-4

1

2

High-throughput

0.445

High

667856

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.445

High

667861

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

667862

GCN20
Protein GCN20

1

5

High-throughput

0.445

High

667869

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.445

High

667879

H3
Histone H3

1

20

High-throughput

0.445

High

667881

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.445

High

667883

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

15

High-throughput

0.445

High

667886

GIS1
Transcriptional activator/repressor GIS1

1

9

High-throughput

0.445

High

667893

ARP9
Actin-like protein ARP9

1

7

High-throughput

0.445

High

667898

RSC58
Chromatin structure-remodeling complex protein RSC58

1

2

High-throughput

0.445

High

667905

RLF2
Chromatin assembly factor 1 subunit p90

1

6

High-throughput

0.445

High

667906

H2AZ
Histone H2A.Z

1

20

High-throughput

0.445

High

342882

ENO2
Enolase 2

1

5

High-throughput

0.437

High

343559

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.437

High

667875

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

141658

YA11B
Truncated transposon Ty1-A Gag-Pol polyprotein

1

0

High-throughput

0.426

High

667857

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

667885

ACL4
Assembly chaperone of RPL4

1

0

High-throughput

0.426

High

667890

DPB4
DNA polymerase epsilon subunit D

1

0

Small-scale

0.426

High

540049

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

3

High-throughput

0.407

High

420242

CALM
Calmodulin

1

0

High-throughput

0.279

Low

636037

CSM1
Monopolin complex subunit CSM1

1

0

Small-scale

0.269

Low

667896

YP097
PX domain-containing protein YPR097W

1

0

Small-scale

0.251

Low

667866

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024