Protein: SRSF2
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)

Gene: SRSF2
Organism: Homo sapiens
Interactions: 201
UniProt ID: Q01130

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0000398 - mRNA splicing, via spliceosome
GO:0003714 - transcription corepressor activity
GO:0003723 - RNA binding
GO:0005080 - protein kinase C binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

942600

SRPK2
SRSF protein kinase 2

4

20

Small-scale

0.902

High

964037

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

2

6

Small-scale

0.807

High

963970

SRSF4
Serine/arginine-rich splicing factor 4

2

20

High-throughput

0.775

High

963188

U2AF1
Splicing factor U2AF 35 kDa subunit

2

1

Small-scale

0.768

High

963969

SRSF1
Serine/arginine-rich splicing factor 1

2

20

Small-scale

0.757

High

408603

KPCB
Protein kinase C beta type

2

5

High-throughput

0.737

High

963988

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.737

High

964002

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

7

High-throughput

0.737

High

934103

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.735

High

960151

CDK6
Cyclin-dependent kinase 6

1

3

Small-scale

0.735

High

800870

MK09
Mitogen-activated protein kinase 9

1

11

High-throughput

0.691

High

851455

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.691

High

871361

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.691

High

963982

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

2

High-throughput

0.691

High

963994

MK14
Mitogen-activated protein kinase 14

1

12

High-throughput

0.691

High

964049

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.691

High

964081

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.691

High

217470

AIRE
Autoimmune regulator

1

14

Small-scale

0.665

High

963989

RNPS1
RNA-binding protein with serine-rich domain 1

1

18

High-throughput

0.665

High

925007

TRA2B
Transformer-2 protein homolog beta

1

20

High-throughput

0.656

High

951927

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.656

High

963965

SRSF2
Serine/arginine-rich splicing factor 2

1

17

High-throughput

0.656

High

369424

ESR1
Estrogen receptor

3

20

High-throughput

0.650

High

964038

ESR2
Estrogen receptor beta

3

20

High-throughput

0.624

High

963968

SRS11
Serine/arginine-rich splicing factor 11

1

5

Small-scale

0.621

High

964072

CEP72
Centrosomal protein of 72 kDa

1

4

High-throughput

0.621

High

148692

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.618

High

162638

XPO1
Exportin-1

1

8

High-throughput

0.618

High

374067

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.618

High

442077

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

19

High-throughput

0.618

High

582231

NUCL
Nucleolin

1

17

Small-scale

0.618

High

641724

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.618

High

899463

MGN
Protein mago nashi homolog

1

1

High-throughput

0.618

High

963966

EWS
RNA-binding protein EWS

1

15

High-throughput

0.618

High

963976

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.618

High

963985

RBM39
RNA-binding protein 39

1

18

High-throughput

0.618

High

963991

SF3A2
Splicing factor 3A subunit 2

1

6

High-throughput

0.618

High

963995

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.618

High

963998

LARP7
La-related protein 7

1

20

High-throughput

0.618

High

964016

CNTRL
Centriolin

1

3

High-throughput

0.618

High

964018

THOC4
THO complex subunit 4

1

15

Small-scale

0.618

High

964054

SRSF8
Serine/arginine-rich splicing factor 8

1

16

High-throughput

0.618

High

964061

RC3H2
Roquin-2

1

16

High-throughput

0.618

High

964075

KS6B2
Ribosomal protein S6 kinase beta-2

1

8

Small-scale

0.618

High

964080

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

2

High-throughput

0.618

High

963981

CUL3
Cullin-3

2

20

High-throughput

0.611

High

964062

MET14
N6-adenosine-methyltransferase non-catalytic subunit

2

5

High-throughput

0.611

High

964040

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.598

High

963975

PAK1
Serine/threonine-protein kinase PAK 1

1

7

Small-scale

0.590

High

964073

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.586

High

244299

BRD4
Bromodomain-containing protein 4

2

4

High-throughput

0.584

High

346549

MYC
Myc proto-oncogene protein

2

16

High-throughput

0.584

High

963972

NCBP1
Nuclear cap-binding protein subunit 1

1

3

High-throughput

0.575

High

964027

SH2D3
SH2 domain-containing protein 3C

2

12

High-throughput

0.571

High

964067

RHG35
Rho GTPase-activating protein 35

2

5

High-throughput

0.571

High

963974

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

3

High-throughput

0.553

High

964014

PAXI1
PAX-interacting protein 1

1

10

High-throughput

0.552

High

964021

CIR1
Corepressor interacting with RBPJ 1

1

0

Small-scale

0.549

High

314628

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.536

High

323407

TTC4
Tetratricopeptide repeat protein 4

1

9

High-throughput

0.536

High

757573

IF4A3
Eukaryotic initiation factor 4A-III

1

20

High-throughput

0.536

High

771448

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.536

High

850905

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.536

High

963978

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.536

High

963979

CUL1
Cullin-1

1

20

High-throughput

0.536

High

963980

CUL2
Cullin-2

1

20

High-throughput

0.536

High

963992

NEDD8
NEDD8

1

2

High-throughput

0.536

High

964017

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

5

High-throughput

0.536

High

964019

ZCH18
Zinc finger CCCH domain-containing protein 18

1

17

High-throughput

0.536

High

964020

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

12

High-throughput

0.536

High

964039

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

964041

CUL5
Cullin-5

1

20

High-throughput

0.536

High

964044

SAHH3
Adenosylhomocysteinase 3

1

1

High-throughput

0.536

High

964050

CDC5L
Cell division cycle 5-like protein

1

7

Small-scale

0.536

High

580978

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.513

High

826511

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.513

High

964030

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.513

High

964063

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

964068

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.513

High

964071

PNPO
Pyridoxine-5'-phosphate oxidase

1

0

High-throughput

0.513

High

964083

KLH20
Kelch-like protein 20

1

0

High-throughput

0.513

High

964066

UBQL4
Ubiquilin-4

1

11

High-throughput

0.508

High

964004

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

4

High-throughput

0.489

High

300117

PRP6
Pre-mRNA-processing factor 6

1

11

High-throughput

0.481

High

536786

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.481

High

537627

NCF1
Neutrophil cytosol factor 1

1

11

Small-scale

0.481

High

551114

ITF2
Transcription factor 4

1

2

High-throughput

0.481

High

963990

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.481

High

964006

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.481

High

964046

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

2

High-throughput

0.481

High

964052

BARD1
BRCA1-associated RING domain protein 1

1

5

High-throughput

0.481

High

964053

LZTS2
Leucine zipper putative tumor suppressor 2

1

16

High-throughput

0.481

High

964070

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

7

Small-scale

0.481

High

117665

MYO1C
Unconventional myosin-Ic

1

2

High-throughput

0.479

High

122670

MEN1
Menin

1

5

High-throughput

0.479

High

125385

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

209901

PRC1
Protein regulator of cytokinesis 1

1

9

High-throughput

0.479

High

227195

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

255693

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

268033

EED
Polycomb protein EED

1

12

High-throughput

0.479

High

272538

OFD1
Centriole and centriolar satellite protein OFD1

1

10

High-throughput

0.479

High

298434

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

303177

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

304123

UBR5
E3 ubiquitin-protein ligase UBR5

1

10

High-throughput

0.479

High

308622

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

312577

ARI2
E3 ubiquitin-protein ligase ARIH2

1

16

High-throughput

0.479

High

326593

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

338289

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

379303

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.479

High

455331

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

569603

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

590850

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

683970

1433S
14-3-3 protein sigma

1

16

Small-scale

0.479

High

707593

H2B1B
Histone H2B type 1-B

1

3

High-throughput

0.479

High

718767

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

737750

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

7

High-throughput

0.479

High

779258

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

803490

BAG6
Large proline-rich protein BAG6

1

9

High-throughput

0.479

High

808521

YAP1
Transcriptional coactivator YAP1

1

12

Small-scale

0.479

High

823897

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

908391

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

909453

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

917125

H4
Histone H4

1

4

High-throughput

0.479

High

918296

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

959355

VIGLN
Vigilin

1

20

High-throughput

0.479

High

961054

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

963967

KIF23
Kinesin-like protein KIF23

1

20

High-throughput

0.479

High

963973

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

963977

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

963983

TRI14
Tripartite motif-containing protein 14

1

7

High-throughput

0.479

High

963986

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

963987

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

963993

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

963996

TECT1
Tectonic-1

1

1

High-throughput

0.479

High

964000

DCAF6
DDB1- and CUL4-associated factor 6

1

7

High-throughput

0.479

High

964003

RC3H1
Roquin-1

1

12

High-throughput

0.479

High

964005

FTM
Protein fantom

1

13

High-throughput

0.479

High

964008

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

964009

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.479

High

964015

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

964022

CUL9
Cullin-9

1

13

High-throughput

0.479

High

964023

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

964024

YAF2
YY1-associated factor 2

1

2

High-throughput

0.479

High

964025

SRRM1
Serine/arginine repetitive matrix protein 1

1

12

High-throughput

0.479

High

964028

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.479

High

964029

POC5
Centrosomal protein POC5

1

3

High-throughput

0.479

High

964031

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

964034

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

964035

FBF1
Fas-binding factor 1

1

11

High-throughput

0.479

High

964042

FBXW7
F-box/WD repeat-containing protein 7

1

9

High-throughput

0.479

High

964047

SCLT1
Sodium channel and clathrin linker 1

1

9

High-throughput

0.479

High

964051

SORT
Sortilin

1

1

High-throughput

0.479

High

964055

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

964057

TRI31
E3 ubiquitin-protein ligase TRIM31

1

8

High-throughput

0.479

High

964060

ECT2
Protein ECT2

1

9

High-throughput

0.479

High

964064

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

964065

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

964074

HDAC6
Histone deacetylase 6

1

8

Small-scale

0.479

High

964076

NXF1
Nuclear RNA export factor 1

1

3

Small-scale

0.479

High

964077

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

964082

CE164
Centrosomal protein of 164 kDa

1

10

High-throughput

0.479

High

964084

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.479

High

964085

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.479

High

964086

MAFB
Transcription factor MafB

1

7

High-throughput

0.479

High

836821

DNLI4
DNA ligase 4

1

0

High-throughput

0.460

High

173572

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

318952

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

714820

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

798861

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

963984

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

963999

MIDN
Midnolin

1

0

High-throughput

0.458

High

401859

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

496868

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

717711

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

891089

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

899616

FGF12
Fibroblast growth factor 12

1

1

Small-scale

0.445

High

964001

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.445

High

964048

CCNL2
Cyclin-L2

1

8

Small-scale

0.445

High

964059

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

20

High-throughput

0.445

High

964078

DDX41
Probable ATP-dependent RNA helicase DDX41

1

9

High-throughput

0.445

High

964079

CCNL1
Cyclin-L1

1

6

Small-scale

0.445

High

963971

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.439

High

265406

KTNA1
Katanin p60 ATPase-containing subunit A1

1

2

High-throughput

0.437

High

384664

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

964010

SAS6
Spindle assembly abnormal protein 6 homolog

1

1

High-throughput

0.437

High

964011

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.437

High

964012

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

964013

CE128
Centrosomal protein of 128 kDa

1

11

High-throughput

0.437

High

964032

TIP
T-cell immunomodulatory protein

1

4

High-throughput

0.437

High

964033

POC1B
POC1 centriolar protein homolog B

1

5

High-throughput

0.437

High

964036

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.437

High

964045

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

964056

RHBT2
Rho-related BTB domain-containing protein 2

1

4

High-throughput

0.437

High

727362

DEK
Protein DEK

1

0

Small-scale

0.426

High

964007

K0930
Uncharacterized protein KIAA0930

1

0

High-throughput

0.279

Low

964026

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.279

Low

964043

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.279

Low

964058

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

964069

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

963997

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024