Protein: VPS28
Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)

Gene: VPS28
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q9UK41

Gene Ontology (top 5):
GO:0000813 - ESCRT I complex
GO:0005737 - cytoplasm
GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1407497

TS101
Tumor susceptibility gene 101 protein

19

8

Small-scale

0.989

High

1437094

VP37B
Vacuolar protein sorting-associated protein 37B

9

8

Small-scale

0.974

High

1338237

VP37A
Vacuolar protein sorting-associated protein 37A

7

8

Small-scale

0.969

High

1294315

VP37D
Vacuolar protein sorting-associated protein 37D

2

8

High-throughput

0.811

High

63277

VP37C
Vacuolar protein sorting-associated protein 37C

2

8

Small-scale

0.768

High

1452944

UBAP1
Ubiquitin-associated protein 1

8

0

Small-scale

0.717

High

1389991

MB12A
Multivesicular body subunit 12A

4

3

High-throughput

0.699

High

1160612

SMN
Survival motor neuron protein

3

1

High-throughput

0.671

High

508805

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

1

Small-scale

0.670

High

1435891

MB12B
Multivesicular body subunit 12B

3

3

High-throughput

0.667

High

262337

SCN2B
Sodium channel regulatory subunit beta-2

4

0

High-throughput

0.661

High

555532

SKIL
Ski-like protein

3

1

High-throughput

0.660

High

1323372

VPS52
Vacuolar protein sorting-associated protein 52 homolog

3

1

High-throughput

0.660

High

1411127

VPS25
Vacuolar protein-sorting-associated protein 25

3

1

Small-scale

0.656

High

1202258

DCAF6
DDB1- and CUL4-associated factor 6

3

0

High-throughput

0.638

High

1257307

STXB4
Syntaxin-binding protein 4

3

0

High-throughput

0.638

High

1392380

AB17A
Alpha/beta hydrolase domain-containing protein 17A

3

0

High-throughput

0.638

High

1406302

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

3

0

High-throughput

0.638

High

1413087

HAUS8
HAUS augmin-like complex subunit 8

3

0

High-throughput

0.638

High

1460911

AKA11
A-kinase anchor protein 11

3

0

High-throughput

0.638

High

988015

GRB2
Growth factor receptor-bound protein 2

3

0

High-throughput

0.634

High

1431525

CARD9
Caspase recruitment domain-containing protein 9

2

1

High-throughput

0.629

High

572275

TRI27
Zinc finger protein RFP

2

1

High-throughput

0.613

High

1359838

RASF5
Ras association domain-containing protein 5

2

1

High-throughput

0.613

High

1403955

HTF4
Transcription factor 12

2

3

High-throughput

0.613

High

1431878

GO45
Golgin-45

2

1

High-throughput

0.613

High

1449156

MBIP1
MAP3K12-binding inhibitory protein 1

2

1

High-throughput

0.613

High

1347410

LMO3
LIM domain only protein 3

2

1

High-throughput

0.606

High

1363739

SHC3
SHC-transforming protein 3

2

1

High-throughput

0.606

High

1452520

ABI2
Abl interactor 2

2

1

High-throughput

0.606

High

1275982

SETX
Probable helicase senataxin

2

0

High-throughput

0.602

High

844076

HD
Huntingtin

2

0

High-throughput

0.594

High

1330114

USBP1
Harmonin-binding protein USHBP1

2

1

High-throughput

0.590

High

1327850

ARRD1
Arrestin domain-containing protein 1

2

0

High-throughput

0.585

High

225720

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

High-throughput

0.580

High

288537

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

0

High-throughput

0.580

High

930817

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

0

High-throughput

0.580

High

933914

GEM
GTP-binding protein GEM

2

0

High-throughput

0.580

High

1057667

CDK18
Cyclin-dependent kinase 18

2

0

High-throughput

0.580

High

1314920

CC146
Coiled-coil domain-containing protein 146

2

0

High-throughput

0.580

High

1405623

TSNAX
Translin-associated protein X

2

0

High-throughput

0.580

High

1417603

BEX2
Protein BEX2

2

0

High-throughput

0.580

High

1458761

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.580

High

1198550

CEP55
Centrosomal protein of 55 kDa

2

0

Small-scale

0.576

High

1290893

VPS36
Vacuolar protein-sorting-associated protein 36

2

4

Small-scale

0.571

High

1063688

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.559

High

1315751

SAXO1
Stabilizer of axonemal microtubules 1

2

1

High-throughput

0.559

High

1436477

AKTIP
AKT-interacting protein

1

0

Small-scale

0.529

High

564536

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

321689

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.513

High

389558

FINC
Fibronectin

1

0

High-throughput

0.513

High

630084

BTF3
Transcription factor BTF3

1

0

High-throughput

0.513

High

638259

S1PR1
Sphingosine 1-phosphate receptor 1

1

0

High-throughput

0.513

High

904446

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.513

High

1041469

ACY1
Aminoacylase-1

1

0

High-throughput

0.513

High

1116114

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1138154

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.513

High

1309844

WDFY1
WD repeat and FYVE domain-containing protein 1

1

0

High-throughput

0.513

High

1339893

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.513

High

1418681

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

1447415

ANLN
Anillin

1

0

High-throughput

0.513

High

1460914

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

1315795

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.486

High

853435

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.481

High

1081515

INCA1
Protein INCA1

1

1

High-throughput

0.481

High

1419262

TRI54
Tripartite motif-containing protein 54

1

3

High-throughput

0.481

High

1121366

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

1392624

SNF8
Vacuolar-sorting protein SNF8

1

2

Small-scale

0.479

High

791821

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

133815

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

173528

XPO1
Exportin-1

1

0

High-throughput

0.458

High

373446

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

378581

IL1B
Interleukin-1 beta

1

0

Small-scale

0.458

High

538084

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

540103

BCR
Breakpoint cluster region protein

1

0

Small-scale

0.458

High

551327

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

831619

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

855284

GPR4
G-prodeshotein coupled receptor 4

1

0

Small-scale

0.458

High

904410

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

1115131

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

1277484

ZFY16
Zinc finger FYVE domain-containing protein 16

1

0

Small-scale

0.458

High

1330972

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1332996

MLKL
Mixed lineage kinase domain-like protein

1

0

Small-scale

0.458

High

1339754

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1434188

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1459878

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

1460915

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

0

High-throughput

0.458

High

117807

M0QZK6
Multivesicular body subunit 12A

1

2

High-throughput

0.445

High

1384297

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

High-throughput

0.445

High

1460913

CD2AP
CD2-associated protein

1

4

Small-scale

0.445

High

587252

ITF2
Transcription factor 4

1

3

High-throughput

0.439

High

1400237

PNMA5
Paraneoplastic antigen-like protein 5

1

1

High-throughput

0.439

High

328185

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.438

High

430593

FABPH
Fatty acid-binding protein, heart

1

0

High-throughput

0.438

High

190515

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.426

High

255274

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

388329

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

530543

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

683366

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.426

High

760783

CD68
Macrosialin

1

0

High-throughput

0.426

High

1153457

CD226
CD226 antigen

1

0

High-throughput

0.426

High

1352583

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

0

High-throughput

0.426

High

1447732

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.426

High

1460912

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.417

High

1218769

UBE2U
Ubiquitin-conjugating enzyme E2 U

3

0

High-throughput

0.347

High

1328456

S2541
Mitochondrial carrier protein SCaMC-3L

3

0

High-throughput

0.347

High

1419754

EVG1
UPF0193 protein EVG1

3

0

High-throughput

0.342

High

1308526

PCP2
Purkinje cell protein 2 homolog

2

0

High-throughput

0.328

High

528527

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.316

High

907203

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

1435951

NRDE2
Nuclear exosome regulator NRDE2

2

0

High-throughput

0.316

High

1453375

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

2

0

High-throughput

0.313

High

1119536

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.279

Low

1277558

UBE3B
Ubiquitin-protein ligase E3B

1

0

High-throughput

0.279

Low

1291709

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1294861

STX12
Syntaxin-12

1

0

High-throughput

0.279

Low

1315331

ZDH23
Palmitoyltransferase ZDHHC23

1

0

High-throughput

0.279

Low

1391315

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

1397796

F227B
Protein FAM227B

1

0

High-throughput

0.279

Low

1434481

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025