Protein: ZEB1
Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)

Gene: ZEB1
Organism: Homo sapiens
Interactions: 168
UniProt ID: P37275

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

741047

CTBP1
C-terminal-binding protein 1

12

10

Small-scale

0.759

High

741004

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.754

High

741003

CTBP2
C-terminal-binding protein 2

6

10

Small-scale

0.729

High

741026

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.697

High

741062

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

3

2

Small-scale

0.678

High

741079

SIR1
NAD-dependent protein deacetylase sirtuin-1

4

6

Small-scale

0.676

High

741078

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

8

Small-scale

0.664

High

741058

DCA15
DDB1- and CUL4-associated factor 15

4

1

Small-scale

0.626

High

741038

EP300
Histone acetyltransferase p300

2

12

Small-scale

0.624

High

316812

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.618

High

741020

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.618

High

741059

E4F1
Transcription factor E4F1

1

19

Small-scale

0.618

High

741071

ZN516
Zinc finger protein 516

1

19

Small-scale

0.618

High

741108

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

235736

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

2

3

Small-scale

0.611

High

741072

HDAC2
Histone deacetylase 2

2

12

High-throughput

0.601

High

154145

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.586

High

386226

P53
Cellular tumor antigen p53

2

7

Small-scale

0.584

High

455158

PARP1
Poly [ADP-ribose] polymerase 1

2

3

Small-scale

0.584

High

741050

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

2

Small-scale

0.584

High

167340

SMAD7
Mothers against decapentaplegic homolog 7

1

20

Small-scale

0.561

High

741046

ATM
Serine-protein kinase ATM

1

3

Small-scale

0.561

High

741105

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.561

High

741037

RBBP4
Histone-binding protein RBBP4

1

7

High-throughput

0.536

High

741048

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.536

High

741040

TRI26
Tripartite motif-containing protein 26

1

20

Small-scale

0.501

High

741076

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.481

High

118845

GTPB1
GTP-binding protein 1

1

3

Small-scale

0.479

High

176133

PPM1G
Protein phosphatase 1G

1

2

Small-scale

0.479

High

178122

IPO8
Importin-8

1

20

Small-scale

0.479

High

202076

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

3

Small-scale

0.479

High

206942

SMAD6
Mothers against decapentaplegic homolog 6

1

20

Small-scale

0.479

High

216462

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

Small-scale

0.479

High

232024

KDM1A
Lysine-specific histone demethylase 1A

1

10

Small-scale

0.479

High

325068

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

Small-scale

0.479

High

397296

ADT2
ADP/ATP translocase 2

1

3

Small-scale

0.479

High

400772

RLA0
Large ribosomal subunit protein uL10

1

3

Small-scale

0.479

High

403102

LA
Lupus La protein

1

4

Small-scale

0.479

High

417997

NPM
Nucleophosmin

1

9

Small-scale

0.479

High

486754

MYB
Transcriptional activator Myb

1

2

High-throughput

0.479

High

501773

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.479

High

503574

HSP7C
Heat shock cognate 71 kDa protein

1

5

Small-scale

0.479

High

515562

SRF
Serum response factor

1

2

High-throughput

0.479

High

516388

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

518270

ADT3
ADP/ATP translocase 3

1

3

Small-scale

0.479

High

523562

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

524819

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

527959

RINI
Ribonuclease inhibitor

1

2

Small-scale

0.479

High

545941

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.479

High

550635

RS2
Small ribosomal subunit protein uS5

1

4

Small-scale

0.479

High

563027

YBOX3
Y-box-binding protein 3

1

11

Small-scale

0.479

High

571335

DDX5
Probable ATP-dependent RNA helicase DDX5

1

3

Small-scale

0.479

High

573153

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.479

High

574943

RL7
Large ribosomal subunit protein uL30

1

4

Small-scale

0.479

High

582103

NUCL
Nucleolin

1

2

Small-scale

0.479

High

616156

RS3
Small ribosomal subunit protein uS3

1

4

Small-scale

0.479

High

620130

PAX7
Paired box protein Pax-7

1

5

High-throughput

0.479

High

620308

GATA2
Endothelial transcription factor GATA-2

1

5

High-throughput

0.479

High

641332

PAX6
Paired box protein Pax-6

1

5

High-throughput

0.479

High

658464

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

672017

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

Small-scale

0.479

High

713916

HS71L
Heat shock 70 kDa protein 1-like

1

5

Small-scale

0.479

High

714117

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.479

High

727481

HNF1B
Hepatocyte nuclear factor 1-beta

1

7

High-throughput

0.479

High

736280

RL4
Large ribosomal subunit protein uL4

1

5

Small-scale

0.479

High

740989

GRP75
Stress-70 protein, mitochondrial

1

9

Small-scale

0.479

High

740990

RL3
Large ribosomal subunit protein uL3

1

5

Small-scale

0.479

High

740991

RS9
Small ribosomal subunit protein uS4

1

1

Small-scale

0.479

High

740992

SOX2
Transcription factor SOX-2

1

15

High-throughput

0.479

High

740993

EFTU
Elongation factor Tu, mitochondrial

1

2

Small-scale

0.479

High

740994

CEBPD
CCAAT/enhancer-binding protein delta

1

16

Small-scale

0.479

High

740995

EMD
Emerin

1

2

Small-scale

0.479

High

740997

RL14
Large ribosomal subunit protein eL14

1

3

Small-scale

0.479

High

740998

RT29
Small ribosomal subunit protein mS29

1

2

Small-scale

0.479

High

740999

SMCA4
Transcription activator BRG1

1

5

Small-scale

0.479

High

741000

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

Small-scale

0.479

High

741001

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

12

Small-scale

0.479

High

741002

NP1L1
Nucleosome assembly protein 1-like 1

1

6

Small-scale

0.479

High

741005

RS3A
Small ribosomal subunit protein eS1

1

2

Small-scale

0.479

High

741008

RS16
Small ribosomal subunit protein uS9

1

7

Small-scale

0.479

High

741009

RS14
Small ribosomal subunit protein uS11

1

2

Small-scale

0.479

High

741011

RS13
Small ribosomal subunit protein uS15

1

2

Small-scale

0.479

High

741012

RL7A
Large ribosomal subunit protein eL8

1

2

Small-scale

0.479

High

741014

RL23A
Large ribosomal subunit protein uL23

1

4

Small-scale

0.479

High

741015

RS6
Small ribosomal subunit protein eS6

1

4

Small-scale

0.479

High

741016

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

741017

YBOX1
Y-box-binding protein 1

1

11

Small-scale

0.479

High

741018

TBA4A
Tubulin alpha-4A chain

1

2

Small-scale

0.479

High

741019

TBB4B
Tubulin beta-4B chain

1

2

Small-scale

0.479

High

741021

RNF4
E3 ubiquitin-protein ligase RNF4

1

18

High-throughput

0.479

High

741022

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

Small-scale

0.479

High

741024

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.479

High

741027

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

Small-scale

0.479

High

741028

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

741029

HEN1
Helix-loop-helix protein 1

1

6

High-throughput

0.479

High

741030

RL6
Large ribosomal subunit protein eL6

1

1

Small-scale

0.479

High

741032

HME1
Homeobox protein engrailed-1

1

6

High-throughput

0.479

High

741033

PRDX1
Peroxiredoxin-1

1

1

Small-scale

0.479

High

741036

DHX9
ATP-dependent RNA helicase A

1

5

Small-scale

0.479

High

741039

TP53B
TP53-binding protein 1

1

5

High-throughput

0.479

High

741041

ILF2
Interleukin enhancer-binding factor 2

1

5

Small-scale

0.479

High

741042

ILF3
Interleukin enhancer-binding factor 3

1

12

Small-scale

0.479

High

741043

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.479

High

741044

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

741045

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

Small-scale

0.479

High

741049

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

741052

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

741054

ELF2
ETS-related transcription factor Elf-2

1

4

High-throughput

0.479

High

741055

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

741056

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

741057

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

15

Small-scale

0.479

High

741060

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

741064

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

5

Small-scale

0.479

High

741065

SERB1
SERPINE1 mRNA-binding protein 1

1

1

Small-scale

0.479

High

741066

TRI58
E3 ubiquitin-protein ligase TRIM58

1

20

Small-scale

0.479

High

741067

DDX1
ATP-dependent RNA helicase DDX1

1

5

Small-scale

0.479

High

741068

H1X
Histone H1.10

1

1

Small-scale

0.479

High

741070

HS105
Heat shock protein 105 kDa

1

15

Small-scale

0.479

High

741073

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

741074

DDX17
Probable ATP-dependent RNA helicase DDX17

1

3

Small-scale

0.479

High

741075

CSN5
COP9 signalosome complex subunit 5

1

1

Small-scale

0.479

High

741077

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

4

Small-scale

0.479

High

741080

CHFR
E3 ubiquitin-protein ligase CHFR

1

12

Small-scale

0.479

High

741082

SAHH3
Adenosylhomocysteinase 3

1

1

Small-scale

0.479

High

741086

MPP8
M-phase phosphoprotein 8

1

4

Small-scale

0.479

High

741087

FEV
Protein FEV

1

5

High-throughput

0.479

High

741088

GNL3
Guanine nucleotide-binding protein-like 3

1

3

Small-scale

0.479

High

741089

UBP26
Ubiquitin carboxyl-terminal hydrolase 26

1

9

Small-scale

0.479

High

741090

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

Small-scale

0.479

High

741091

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

2

Small-scale

0.479

High

741092

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

4

Small-scale

0.479

High

741093

DDX21
Nucleolar RNA helicase 2

1

8

Small-scale

0.479

High

741097

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

1

Small-scale

0.479

High

741098

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

741100

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.479

High

741101

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

1

Small-scale

0.479

High

741102

UBP18
Ubl carboxyl-terminal hydrolase 18

1

9

Small-scale

0.479

High

741103

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

Small-scale

0.479

High

741104

LHX6
LIM/homeobox protein Lhx6

1

7

High-throughput

0.479

High

741106

RTRAF
RNA transcription, translation and transport factor protein

1

1

Small-scale

0.479

High

741051

NC2A
Dr1-associated corepressor

1

0

Small-scale

0.460

High

400244

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.458

High

548063

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.458

High

653177

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.458

High

741006

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.458

High

741007

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.458

High

741010

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

741013

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

Small-scale

0.458

High

741034

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

741053

ELOB
Elongin-B

1

0

High-throughput

0.458

High

741081

PTCD3
Small ribosomal subunit protein mS39

1

0

Small-scale

0.458

High

741083

VCIP1
Deubiquitinating protein VCPIP1

1

0

Small-scale

0.458

High

741085

INT14
Integrator complex subunit 14

1

0

Small-scale

0.458

High

741094

INT13
Integrator complex subunit 13

1

0

Small-scale

0.458

High

741095

INT10
Integrator complex subunit 10

1

0

Small-scale

0.458

High

741096

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

741107

RTCB
RNA-splicing ligase RtcB homolog

1

0

Small-scale

0.458

High

521769

CADH1
Cadherin-1

1

2

Small-scale

0.437

High

740996

SERPH
Serpin H1

1

3

Small-scale

0.437

High

741023

RT35
Small ribosomal subunit protein mS35

1

1

Small-scale

0.437

High

741025

S25A3
Solute carrier family 25 member 3

1

4

Small-scale

0.437

High

741035

CKAP4
Cytoskeleton-associated protein 4

1

9

Small-scale

0.437

High

741061

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

7

Small-scale

0.437

High

741063

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

1

4

Small-scale

0.437

High

741099

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

Small-scale

0.437

High

741031

EF1A2
Elongation factor 1-alpha 2

1

0

Small-scale

0.249

Low

741069

RT27
Small ribosomal subunit protein mS27

1

0

Small-scale

0.249

Low

741084

INT15
Integrator complex subunit 15

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024