Protein: KS6A3
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)

Gene: KS6A3, RPS6KA3
Organism: Homo sapiens
Interactions: 189
UniProt ID: P51812

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001501 - skeletal system development
GO:0002224 - toll-like receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658860

MK01
Mitogen-activated protein kinase 1

13

20

Small-scale

0.979

High

850655

KS6A1
Ribosomal protein S6 kinase alpha-1

6

15

High-throughput

0.949

High

850634

CSK2B
Casein kinase II subunit beta

6

7

Small-scale

0.944

High

850660

CDC37
Hsp90 co-chaperone Cdc37

5

14

High-throughput

0.919

High

507919

FGFR1
Fibroblast growth factor receptor 1

4

20

Small-scale

0.915

High

647522

MK03
Mitogen-activated protein kinase 3

5

20

Small-scale

0.912

High

601482

FGFR2
Fibroblast growth factor receptor 2

4

20

High-throughput

0.906

High

850654

KS6A2
Ribosomal protein S6 kinase alpha-2

4

15

High-throughput

0.892

High

254459

ROCK2
Rho-associated protein kinase 2

3

10

High-throughput

0.871

High

412095

FYN
Tyrosine-protein kinase Fyn

3

19

Small-scale

0.866

High

850644

GRSF1
G-rich sequence factor 1

3

12

High-throughput

0.861

High

431672

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.817

High

438011

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.817

High

850653

PEA15
Astrocytic phosphoprotein PEA-15

2

1

Small-scale

0.812

High

226918

PRKN
E3 ubiquitin-protein ligase parkin

2

15

High-throughput

0.754

High

338157

EGFR
Epidermal growth factor receptor

2

18

High-throughput

0.754

High

453227

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

7

High-throughput

0.737

High

498233

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

9

High-throughput

0.737

High

582149

NUCL
Nucleolin

2

7

High-throughput

0.737

High

609766

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

11

High-throughput

0.737

High

850622

HNRPM
Heterogeneous nuclear ribonucleoprotein M

2

8

High-throughput

0.737

High

850635

CSK21
Casein kinase II subunit alpha

2

18

High-throughput

0.737

High

850656

SF3B4
Splicing factor 3B subunit 4

2

7

High-throughput

0.737

High

850665

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

2

14

High-throughput

0.737

High

850684

CSK23
Casein kinase II subunit alpha 3

2

16

High-throughput

0.737

High

850661

AMHR2
Anti-Muellerian hormone type-2 receptor

1

3

High-throughput

0.691

High

850708

STRAB
STE20-related kinase adapter protein beta

1

12

High-throughput

0.691

High

157880

KLF11
Krueppel-like factor 11

1

6

High-throughput

0.665

High

803445

BAG6
Large proline-rich protein BAG6

1

9

High-throughput

0.665

High

850714

NEK6
Serine/threonine-protein kinase Nek6

1

16

High-throughput

0.665

High

522867

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

609219

FGFR3
Fibroblast growth factor receptor 3

1

20

Small-scale

0.647

High

639702

IKBA
NF-kappa-B inhibitor alpha

1

8

Small-scale

0.647

High

850680

RPTOR
Regulatory-associated protein of mTOR

1

12

Small-scale

0.647

High

850710

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

5

Small-scale

0.647

High

434163

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.646

High

850636

H31
Histone H3.1

3

13

Small-scale

0.641

High

850686

PDC6I
Programmed cell death 6-interacting protein

2

12

High-throughput

0.628

High

850697

TRI11
E3 ubiquitin-protein ligase TRIM11

2

2

High-throughput

0.628

High

850676

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

2

7

High-throughput

0.621

High

182119

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

19

Small-scale

0.618

High

349992

RASK
GTPase KRas

1

8

High-throughput

0.618

High

373913

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

384525

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

586628

CSK22
Casein kinase II subunit alpha'

1

15

High-throughput

0.618

High

607926

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

779057

CCNF
Cyclin-F

1

6

High-throughput

0.618

High

850621

KS6A3
Ribosomal protein S6 kinase alpha-3

1

15

High-throughput

0.618

High

850632

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

High-throughput

0.618

High

850649

SNTB2
Beta-2-syntrophin

1

17

High-throughput

0.618

High

850659

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

850672

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

850679

MAPK5
MAP kinase-activated protein kinase 5

1

16

High-throughput

0.618

High

850701

RHOV
Rho-related GTP-binding protein RhoV

1

12

High-throughput

0.618

High

850711

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.618

High

850712

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.618

High

850719

ARHGC
Rho guanine nucleotide exchange factor 12

2

6

High-throughput

0.611

High

850699

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

656991

5HT2A
5-hydroxytryptamine receptor 2A

1

2

Small-scale

0.590

High

850721

TRM9B
Probable tRNA methyltransferase 9B

2

0

High-throughput

0.585

High

850625

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

6

High-throughput

0.584

High

850652

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.578

High

850666

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

850667

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

High-throughput

0.575

High

850678

MISP
Mitotic interactor and substrate of PLK1

2

2

High-throughput

0.574

High

323646

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.571

High

388322

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

418061

NPM
Nucleophosmin

2

2

High-throughput

0.571

High

420815

H2B1J
Histone H2B type 1-J

2

20

High-throughput

0.571

High

501852

BIP
Endoplasmic reticulum chaperone BiP

2

14

High-throughput

0.571

High

503719

HSP7C
Heat shock cognate 71 kDa protein

2

7

High-throughput

0.571

High

564041

HSP76
Heat shock 70 kDa protein 6

2

7

High-throughput

0.571

High

617936

H2B1O
Histone H2B type 1-O

2

20

High-throughput

0.571

High

707559

H2B1B
Histone H2B type 1-B

2

20

High-throughput

0.571

High

751545

GRP75
Stress-70 protein, mitochondrial

2

18

High-throughput

0.571

High

850631

H4
Histone H4

2

2

High-throughput

0.571

High

850637

H33
Histone H3.3

2

13

High-throughput

0.571

High

850639

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

6

High-throughput

0.571

High

850643

RBBP4
Histone-binding protein RBBP4

2

6

High-throughput

0.571

High

850662

H31T
Histone H3.1t

2

13

High-throughput

0.571

High

850663

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.571

High

850669

H3C
Histone H3.3C

2

13

High-throughput

0.571

High

850673

H32
Histone H3.2

2

13

High-throughput

0.571

High

850687

HS105
Heat shock protein 105 kDa

2

15

High-throughput

0.571

High

850692

H2A1C
Histone H2A type 1-C

2

8

High-throughput

0.571

High

496604

TAU
Microtubule-associated protein tau

1

13

Small-scale

0.569

High

787426

MTOR
Serine/threonine-protein kinase mTOR

1

20

Small-scale

0.568

High

850723

ZMYM5
Zinc finger MYM-type protein 5

2

1

High-throughput

0.558

High

850648

PLD1
Phospholipase D1

1

1

Small-scale

0.553

High

564841

HMGA1
High mobility group protein HMG-I/HMG-Y

2

0

High-throughput

0.547

High

850626

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

0

High-throughput

0.547

High

850681

CCAR2
Cell cycle and apoptosis regulator protein 2

2

0

High-throughput

0.547

High

153900

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.536

High

257167

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

3

High-throughput

0.536

High

850641

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

7

High-throughput

0.536

High

850683

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.536

High

850691

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

High-throughput

0.536

High

850693

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

850695

ASTRA
Protein Aster-A

1

2

High-throughput

0.536

High

850709

NDEL1
Nuclear distribution protein nudE-like 1

1

4

High-throughput

0.536

High

391606

H2A1B
Histone H2A type 1-B/E

2

8

High-throughput

0.521

High

488953

H14
Histone H1.4

2

3

High-throughput

0.521

High

559354

H13
Histone H1.3

2

3

High-throughput

0.521

High

850674

H2A3
Histone H2A type 3

2

8

High-throughput

0.521

High

850700

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

1

High-throughput

0.521

High

369218

ESR1
Estrogen receptor

1

20

Small-scale

0.515

High

450992

GNAO

1

2

High-throughput

0.515

High

655279

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

High-throughput

0.515

High

822573

MASP1
Mannan-binding lectin serine protease 1

1

6

High-throughput

0.508

High

850704

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

7

High-throughput

0.508

High

239090

CTND1
Catenin delta-1

1

7

High-throughput

0.501

High

386351

P53
Cellular tumor antigen p53

1

5

Small-scale

0.501

High

396903

HMGN1
Non-histone chromosomal protein HMG-14

1

2

Small-scale

0.501

High

555363

H2AX
Histone H2AX

1

8

Small-scale

0.501

High

776616

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.501

High

808054

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

14

High-throughput

0.501

High

850629

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

850633

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.501

High

850646

ATM
Serine-protein kinase ATM

1

19

Small-scale

0.501

High

850707

LST8
Target of rapamycin complex subunit LST8

1

3

Small-scale

0.501

High

850726

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

850638

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.489

High

850657

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

20

High-throughput

0.489

High

850668

IIGP5
Interferon-inducible GTPase 5

1

2

High-throughput

0.489

High

850698

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

850727

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

1

High-throughput

0.489

High

850623

SPSY
Spermine synthase

1

0

High-throughput

0.486

High

118853

GTPB1
GTP-binding protein 1

1

7

High-throughput

0.479

High

296888

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

302123

AP2A2
AP-2 complex subunit alpha-2

1

3

High-throughput

0.479

High

317936

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

7

Small-scale

0.479

High

552283

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

569423

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

607612

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.479

High

617484

CRCM
Colorectal mutant cancer protein

1

8

High-throughput

0.479

High

640223

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

5

High-throughput

0.479

High

643274

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

646741

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

650723

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

675140

CLIP1
CAP-Gly domain-containing linker protein 1

1

17

High-throughput

0.479

High

683216

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

687045

FOXN2
Forkhead box protein N2

1

1

Small-scale

0.479

High

720021

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

823729

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

850627

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

2

High-throughput

0.479

High

850630

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

850640

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

850642

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

850645

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.479

High

850647

CTBP1
C-terminal-binding protein 1

1

5

High-throughput

0.479

High

850650

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.479

High

850651

SCRIB
Protein scribble homolog

1

6

High-throughput

0.479

High

850658

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

850664

WASC4
WASH complex subunit 4

1

2

High-throughput

0.479

High

850682

DOCK4
Dedicator of cytokinesis protein 4

1

6

High-throughput

0.479

High

850685

FRS2
Fibroblast growth factor receptor substrate 2

1

2

High-throughput

0.479

High

850688

HDAC2
Histone deacetylase 2

1

8

High-throughput

0.479

High

850689

CBP
CREB-binding protein

1

13

Small-scale

0.479

High

850690

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.479

High

850696

AP2M1
AP-2 complex subunit mu

1

5

High-throughput

0.479

High

850702

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

850715

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

850716

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

850718

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.479

High

850720

AKA7G
A-kinase anchor protein 7 isoform gamma

1

5

High-throughput

0.479

High

850722

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

850728

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

2

High-throughput

0.479

High

850713

BARX1
Homeobox protein BarH-like 1

1

2

High-throughput

0.464

High

785774

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

850628

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.458

High

850725

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

517142

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.457

High

708211

ERD22
ER lumen protein-retaining receptor 2

1

2

High-throughput

0.437

High

850671

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.437

High

850675

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

850705

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.437

High

850706

LMF2
Lipase maturation factor 2

1

1

High-throughput

0.437

High

850717

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

850724

GGA2
ADP-ribosylation factor-binding protein GGA2

1

4

High-throughput

0.437

High

484508

ECE2
Endothelin-converting enzyme 2

1

2

High-throughput

0.407

High

850677

TM139
Transmembrane protein 139

3

0

High-throughput

0.347

High

375722

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.279

Low

824909

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.279

Low

850624

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

850694

ARK2N
Protein ARK2N

1

0

High-throughput

0.279

Low

850670

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

579515

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.265

Low

850703

SFXN2
Sideroflexin-2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024