Protein: WASP
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)

Gene: WASP, WAS
Organism: Homo sapiens
Interactions: 104
UniProt ID: P42768

Gene Ontology (top 5):
GO:0002625 - regulation of T cell antigen processing and presentation
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005884 - actin filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

790653

CDC42
Cell division control protein 42 homolog

16

20

Small-scale

0.986

High

206681

WIPF1
WAS/WASL-interacting protein family member 1

12

14

Small-scale

0.983

High

790642

WASP
Actin nucleation-promoting factor WAS

3

15

Small-scale

0.847

High

790655

ARP2
Actin-related protein 2

3

14

Small-scale

0.827

High

790680

WIPF2
WAS/WASL-interacting protein family member 2

2

6

Small-scale

0.757

High

790687

RHOJ
Rho-related GTP-binding protein RhoJ

2

20

Small-scale

0.757

High

412072

FYN
Tyrosine-protein kinase Fyn

5

20

Small-scale

0.725

High

557631

NCK1
SH2/SH3 adapter protein NCK1

4

20

Small-scale

0.699

High

790664

BTK
Tyrosine-protein kinase BTK

4

20

Small-scale

0.696

High

454805

FGR
Tyrosine-protein kinase Fgr

3

20

Small-scale

0.670

High

790657

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.667

High

207777

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

3

20

Small-scale

0.664

High

169044

ARPC3
Actin-related protein 2/3 complex subunit 3

3

5

Small-scale

0.661

High

580954

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

2

Small-scale

0.651

High

790646

VASP
Vasodilator-stimulated phosphoprotein

1

10

Small-scale

0.647

High

790658

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

790660

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.647

High

790689

ABI3
ABI gene family member 3

2

20

High-throughput

0.640

High

442791

HCK
Tyrosine-protein kinase HCK

2

20

Small-scale

0.639

High

790675

CIP4
Cdc42-interacting protein 4

2

20

Small-scale

0.633

High

790688

ITSN2
Intersectin-2

2

20

Small-scale

0.633

High

790696

SNX9
Sorting nexin-9

2

20

Small-scale

0.631

High

209002

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.631

High

522841

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.629

High

790665

ACK1
Activated CDC42 kinase 1

2

20

Small-scale

0.629

High

655256

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

5

Small-scale

0.624

High

790645

RBP2
E3 SUMO-protein ligase RanBP2

2

3

Small-scale

0.624

High

545246

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

Small-scale

0.618

High

564443

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

Small-scale

0.618

High

790652

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

Small-scale

0.618

High

790656

RAN
GTP-binding nuclear protein Ran

1

6

Small-scale

0.618

High

790666

ITK
Tyrosine-protein kinase ITK/TSK

2

20

Small-scale

0.613

High

411631

LCK
Tyrosine-protein kinase Lck

2

20

Small-scale

0.611

High

242926

GAS7
Growth arrest-specific protein 7

2

20

Small-scale

0.608

High

790650

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

20

High-throughput

0.606

High

168746

ARC1B
Actin-related protein 2/3 complex subunit 1B

2

11

Small-scale

0.595

High

790663

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

10

Small-scale

0.595

High

790676

ITSN1
Intersectin-1

2

20

Small-scale

0.584

High

790685

FNBP1
Formin-binding protein 1

2

20

Small-scale

0.584

High

790686

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

2

20

Small-scale

0.584

High

790654

ARP3
Actin-related protein 3

1

15

Small-scale

0.575

High

600745

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

3

Small-scale

0.573

High

298960

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

High-throughput

0.573

High

790683

APBP2
Amyloid protein-binding protein 2

1

2

High-throughput

0.573

High

790644

CRKL
Crk-like protein

1

20

Small-scale

0.561

High

790651

ARPC4
Actin-related protein 2/3 complex subunit 4

1

4

Small-scale

0.536

High

269208

WBP4
WW domain-binding protein 4

1

8

High-throughput

0.527

High

788976

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.527

High

508383

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.513

High

789696

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

150898

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

8

High-throughput

0.508

High

120854

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.501

High

154757

TCRG1
Transcription elongation regulator 1

1

9

High-throughput

0.501

High

168896

ARPC2
Actin-related protein 2/3 complex subunit 2

1

6

Small-scale

0.501

High

441188

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

6

High-throughput

0.501

High

552145

RFA2
Replication protein A 32 kDa subunit

1

4

Small-scale

0.501

High

616908

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

10

High-throughput

0.501

High

617086

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

6

High-throughput

0.501

High

617160

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

8

High-throughput

0.501

High

650579

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

Small-scale

0.501

High

719884

RFA3
Replication protein A 14 kDa subunit

1

3

Small-scale

0.501

High

790667

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

9

High-throughput

0.501

High

790677

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

6

High-throughput

0.501

High

790692

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

20

Small-scale

0.501

High

790695

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

11

High-throughput

0.501

High

508855

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.484

High

790661

TOP2B
DNA topoisomerase 2-beta

1

3

Small-scale

0.484

High

207513

RGS14
Regulator of G-protein signaling 14

1

1

High-throughput

0.481

High

297961

FCSD2
F-BAR and double SH3 domains protein 2

1

20

High-throughput

0.481

High

790684

CBP
CREB-binding protein

1

9

Small-scale

0.481

High

131393

IMA4
Importin subunit alpha-4

1

5

Small-scale

0.479

High

134842

IMA3
Importin subunit alpha-3

1

5

Small-scale

0.479

High

162478

XPO1
Exportin-1

1

5

Small-scale

0.479

High

165823

KDM6B
Lysine-specific demethylase 6B

1

13

Small-scale

0.479

High

167746

FYB1
FYN-binding protein 1

1

6

Small-scale

0.479

High

211523

ACTN4
Alpha-actinin-4

1

4

Small-scale

0.479

High

253325

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

5

Small-scale

0.479

High

256952

KDM4A
Lysine-specific demethylase 4A

1

1

Small-scale

0.479

High

338087

EGFR
Epidermal growth factor receptor

1

11

Small-scale

0.479

High

536570

HCLS1
Hematopoietic lineage cell-specific protein

1

20

Small-scale

0.479

High

610282

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

790647

IMA1
Importin subunit alpha-1

1

5

Small-scale

0.479

High

790648

NUP98
Nuclear pore complex protein Nup98-Nup96

1

4

Small-scale

0.479

High

790649

XPO2
Exportin-2

1

3

Small-scale

0.479

High

790659

UBC9
SUMO-conjugating enzyme UBC9

1

6

Small-scale

0.479

High

790662

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

790668

LCP2
Lymphocyte cytosolic protein 2

1

6

Small-scale

0.479

High

790669

CBLB
E3 ubiquitin-protein ligase CBL-B

1

7

Small-scale

0.479

High

790670

CUL4B
Cullin-4B

1

7

High-throughput

0.479

High

790671

SRC8
Src substrate cortactin

1

20

Small-scale

0.479

High

790673

IMB1
Importin subunit beta-1

1

4

Small-scale

0.479

High

790674

RBBP5
Retinoblastoma-binding protein 5

1

10

Small-scale

0.479

High

790678

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.479

High

790679

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

2

Small-scale

0.479

High

790681

SNX33
Sorting nexin-33

1

20

Small-scale

0.479

High

790693

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

20

Small-scale

0.479

High

790694

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

20

Small-scale

0.479

High

790643

RAGP1
Ran GTPase-activating protein 1

1

0

Small-scale

0.458

High

790690

SAE1
SUMO-activating enzyme subunit 1

1

0

Small-scale

0.458

High

263548

PR40A
Pre-mRNA-processing factor 40 homolog A

1

20

High-throughput

0.457

High

790682

ROBO4
Roundabout homolog 4

1

8

Small-scale

0.457

High

790672

RBM39
RNA-binding protein 39

1

6

High-throughput

0.437

High

790691

SAE2
SUMO-activating enzyme subunit 2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024