Protein: PLRG1
Pleiotropic regulator 1

Gene: PLRG1
Organism: Homo sapiens
Interactions: 151
UniProt ID: O43660

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0001650 - fibrillar center
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

209498

PRP19
Pre-mRNA-processing factor 19

8

19

Small-scale

0.972

High

209432

SNW1
SNW domain-containing protein 1

2

5

High-throughput

0.789

High

209470

CDC5L
Cell division cycle 5-like protein

9

10

Small-scale

0.759

High

209452

PRP8
Pre-mRNA-processing-splicing factor 8

2

6

High-throughput

0.754

High

209365

SPF27
Pre-mRNA-splicing factor SPF27

5

5

Small-scale

0.727

High

209474

YJU2
Splicing factor YJU2

3

2

High-throughput

0.667

High

209481

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

10

High-throughput

0.665

High

209472

USB1
U6 snRNA phosphodiesterase 1

4

0

Small-scale

0.664

High

209372

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.640

High

209359

AQR
RNA helicase aquarius

2

9

High-throughput

0.628

High

209371

SYF2
Pre-mRNA-splicing factor SYF2

2

1

High-throughput

0.628

High

209433

CUL3
Cullin-3

2

20

High-throughput

0.628

High

209446

C19L2
CWF19-like protein 2

2

2

High-throughput

0.628

High

209473

GPTC1
G patch domain-containing protein 1

2

7

High-throughput

0.628

High

209476

CRNL1
Crooked neck-like protein 1

2

20

High-throughput

0.628

High

209480

DHX35
Probable ATP-dependent RNA helicase DHX35

2

20

High-throughput

0.628

High

209486

SYF1
Pre-mRNA-splicing factor SYF1

2

20

High-throughput

0.628

High

209495

ISY1
Pre-mRNA-splicing factor ISY1 homolog

2

2

High-throughput

0.628

High

209499

PPIE
Peptidyl-prolyl cis-trans isomerase E

2

3

High-throughput

0.628

High

209364

SF3B1
Splicing factor 3B subunit 1

2

10

High-throughput

0.625

High

209416

WDR5
WD repeat-containing protein 5

1

17

High-throughput

0.618

High

209417

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.618

High

209437

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.618

High

209441

EZH2
Histone-lysine N-methyltransferase EZH2

1

17

High-throughput

0.618

High

209467

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

15

High-throughput

0.618

High

209477

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

3

High-throughput

0.618

High

209487

ANLN
Anillin

1

4

High-throughput

0.618

High

209497

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.618

High

209502

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.618

High

209401

FUS
RNA-binding protein FUS

2

17

High-throughput

0.611

High

209434

RBM39
RNA-binding protein 39

2

15

High-throughput

0.611

High

209439

SF3A2
Splicing factor 3A subunit 2

2

7

High-throughput

0.611

High

209464

CTBL1
Beta-catenin-like protein 1

2

1

Small-scale

0.611

High

209409

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

8

High-throughput

0.592

High

209455

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.586

High

209358

PRKN
E3 ubiquitin-protein ligase parkin

2

18

High-throughput

0.584

High

209361

BRD4
Bromodomain-containing protein 4

2

19

High-throughput

0.584

High

209419

H4
Histone H4

2

7

High-throughput

0.584

High

209490

CWC15
Spliceosome-associated protein CWC15 homolog

1

1

Small-scale

0.575

High

209378

JUN
Transcription factor Jun

2

15

High-throughput

0.571

High

148168

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.553

High

209454

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.553

High

209479

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.553

High

209484

RC3H2
Roquin-2

1

12

High-throughput

0.553

High

209492

DYH17
Dynein axonemal heavy chain 17

1

7

High-throughput

0.553

High

209377

A4
Amyloid-beta precursor protein

2

3

High-throughput

0.550

High

209459

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

2

High-throughput

0.541

High

157156

BACH1
Transcription regulator protein BACH1

1

13

High-throughput

0.536

High

209362

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

13

High-throughput

0.536

High

209381

RU2B
U2 small nuclear ribonucleoprotein B''

1

17

High-throughput

0.536

High

209383

SNRPA
U1 small nuclear ribonucleoprotein A

1

13

High-throughput

0.536

High

209384

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

209387

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

209388

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

6

High-throughput

0.536

High

209392

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.536

High

209402

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

209403

IF4A3
Eukaryotic initiation factor 4A-III

1

18

High-throughput

0.536

High

209418

RUXF
Small nuclear ribonucleoprotein F

1

18

High-throughput

0.536

High

209422

RBM6
RNA-binding protein 6

1

18

High-throughput

0.536

High

209426

FMR1
Fragile X messenger ribonucleoprotein 1

1

11

High-throughput

0.536

High

209427

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

209430

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

20

High-throughput

0.536

High

209431

HDAC1
Histone deacetylase 1

1

18

High-throughput

0.536

High

209440

SF3A1
Splicing factor 3A subunit 1

1

10

High-throughput

0.536

High

209444

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

17

High-throughput

0.536

High

209485

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

16

High-throughput

0.536

High

209453

RHG36
Rho GTPase-activating protein 36

2

6

High-throughput

0.521

High

209491

RHG23
Rho GTPase-activating protein 23

2

3

High-throughput

0.521

High

209412

ATX1
Ataxin-1

1

4

High-throughput

0.515

High

209380

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

209408

CNN1
Calponin-1

1

4

High-throughput

0.512

High

209391

EGLN
Endoglin

1

2

High-throughput

0.489

High

209393

MX1
Interferon-induced GTP-binding protein Mx1

1

3

Small-scale

0.481

High

122384

MEN1
Menin

1

4

High-throughput

0.479

High

125024

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

162231

XPO1
Exportin-1

1

12

High-throughput

0.479

High

209360

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

209363

TAD2A
Transcriptional adapter 2-alpha

1

20

High-throughput

0.479

High

209366

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

209367

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

209369

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

3

High-throughput

0.479

High

209373

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

209374

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

209375

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

209379

GLI1
Zinc finger protein GLI1

1

6

Small-scale

0.479

High

209382

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

12

High-throughput

0.479

High

209385

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

209386

HSP7C
Heat shock cognate 71 kDa protein

1

11

High-throughput

0.479

High

209389

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

209390

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

209394

U2AF2
Splicing factor U2AF 65 kDa subunit

1

19

Small-scale

0.479

High

209395

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

209396

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

209397

H2B1B
Histone H2B type 1-B

1

8

High-throughput

0.479

High

209398

BMI1
Polycomb complex protein BMI-1

1

17

High-throughput

0.479

High

209399

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

209400

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

209404

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

209405

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

209407

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.479

High

209410

IMA1
Importin subunit alpha-1

1

6

Small-scale

0.479

High

209411

IMA5
Importin subunit alpha-5

1

6

Small-scale

0.479

High

209413

TERA
Transitional endoplasmic reticulum ATPase

1

6

Small-scale

0.479

High

209415

MGN
Protein mago nashi homolog

1

1

High-throughput

0.479

High

209420

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.479

High

209421

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

209424

VIGLN
Vigilin

1

18

High-throughput

0.479

High

209425

MECOM
Histone-lysine N-methyltransferase MECOM

1

4

High-throughput

0.479

High

209428

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

209429

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

209435

DHX8
ATP-dependent RNA helicase DHX8

1

19

High-throughput

0.479

High

209436

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

209438

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

209443

E2F4
Transcription factor E2F4

1

4

High-throughput

0.479

High

209445

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

209447

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

209456

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.479

High

209457

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

209458

SRRM1
Serine/arginine repetitive matrix protein 1

1

20

High-throughput

0.479

High

209462

SNIP1
Smad nuclear-interacting protein 1

1

5

High-throughput

0.479

High

209463

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

209465

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

209466

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

209471

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

209475

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

209483

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

209489

DJC17
DnaJ homolog subfamily C member 17

1

14

High-throughput

0.479

High

209493

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

209496

HECD1
E3 ubiquitin-protein ligase HECTD1

1

13

High-throughput

0.479

High

209500

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.479

High

209501

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

19

High-throughput

0.479

High

209503

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

1

High-throughput

0.479

High

209448

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.458

High

209460

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

209449

ODFP2
Outer dense fiber protein 2

1

14

High-throughput

0.445

High

209482

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.445

High

209494

DDX41
Probable ATP-dependent RNA helicase DDX41

1

15

High-throughput

0.445

High

209370

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

16

High-throughput

0.437

High

209376

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

209442

CCDC6
Coiled-coil domain-containing protein 6

1

18

High-throughput

0.437

High

209451

RC3H1
Roquin-1

1

4

High-throughput

0.437

High

209468

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

209469

RN157
E3 ubiquitin ligase RNF157

1

1

Small-scale

0.437

High

209478

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.437

High

209406

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.408

High

209368

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.407

High

209414

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.407

High

209461

LINES
Protein Lines homolog 1

2

0

High-throughput

0.328

High

209423

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

209488

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.249

Low

209450

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024