Protein: PJA2
E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)

Gene: PJA2
Organism: Homo sapiens
Interactions: 146
UniProt ID: O43164

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

196294

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

Small-scale

0.906

High

196289

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.857

High

196238

PJA2
E3 ubiquitin-protein ligase Praja-2

2

12

Small-scale

0.768

High

158997

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

High-throughput

0.698

High

196282

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.698

High

196290

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

196334

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

196372

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

196373

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

20

High-throughput

0.698

High

196336

AP2M1
AP-2 complex subunit mu

3

1

High-throughput

0.667

High

196350

MOB1A
MOB kinase activator 1A

3

0

Small-scale

0.647

High

196261

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

2

1

Small-scale

0.634

High

196319

RHG36
Rho GTPase-activating protein 36

4

1

High-throughput

0.630

High

196363

UBQL2
Ubiquilin-2

1

8

High-throughput

0.618

High

196303

CUL3
Cullin-3

2

3

High-throughput

0.611

High

196257

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

1

Small-scale

0.578

High

196323

KSR1
Kinase suppressor of Ras 1

1

9

Small-scale

0.578

High

196345

IQCN
IQ domain-containing protein N

2

1

High-throughput

0.574

High

196318

KSR2
Kinase suppressor of Ras 2

1

5

Small-scale

0.561

High

196328

BBS1
Bardet-Biedl syndrome 1 protein

1

1

Small-scale

0.561

High

196343

BBS2
Bardet-Biedl syndrome 2 protein

1

0

Small-scale

0.549

High

196374

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

0

Small-scale

0.537

High

196248

UBXN7
UBX domain-containing protein 7

1

9

High-throughput

0.536

High

196296

UBXN1
UBX domain-containing protein 1

1

6

High-throughput

0.536

High

196305

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.536

High

196327

ARRD4
Arrestin domain-containing protein 4

1

6

High-throughput

0.536

High

196331

ARRD2
Arrestin domain-containing protein 2

1

6

High-throughput

0.536

High

196333

SPSB4
SPRY domain-containing SOCS box protein 4

1

2

High-throughput

0.536

High

196335

FAF2
FAS-associated factor 2

1

9

High-throughput

0.536

High

196338

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

10

High-throughput

0.536

High

196347

TXNIP
Thioredoxin-interacting protein

1

6

High-throughput

0.536

High

196349

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

196370

FAF1
FAS-associated factor 1

1

10

High-throughput

0.536

High

196293

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

6

High-throughput

0.515

High

196337

DNJC1
DnaJ homolog subfamily C member 1

1

5

High-throughput

0.515

High

196260

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

196341

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

196377

MAGD1
Melanoma-associated antigen D1

1

10

Small-scale

0.481

High

162219

XPO1
Exportin-1

1

2

High-throughput

0.479

High

196241

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

196247

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

196251

LATS1
Serine/threonine-protein kinase LATS1

1

4

Small-scale

0.479

High

196255

CY1
Cytochrome c1, heme protein, mitochondrial

1

1

Small-scale

0.479

High

196262

PGAM1
Phosphoglycerate mutase 1

1

3

Small-scale

0.479

High

196263

VATB2
V-type proton ATPase subunit B, brain isoform

1

1

Small-scale

0.479

High

196264

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

Small-scale

0.479

High

196269

1433S
14-3-3 protein sigma

1

13

High-throughput

0.479

High

196270

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

1

Small-scale

0.479

High

196273

MTOR
Serine/threonine-protein kinase mTOR

1

3

Small-scale

0.479

High

196277

ATPO
ATP synthase subunit O, mitochondrial

1

2

Small-scale

0.479

High

196287

RAB8A
Ras-related protein Rab-8A

1

12

Small-scale

0.479

High

196288

RAB10
Ras-related protein Rab-10

1

12

Small-scale

0.479

High

196291

RAB14
Ras-related protein Rab-14

1

12

Small-scale

0.479

High

196292

1433G
14-3-3 protein gamma

1

13

High-throughput

0.479

High

196297

1433F
14-3-3 protein eta

1

13

High-throughput

0.479

High

196298

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

Small-scale

0.479

High

196300

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

196302

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

196306

RHEB
GTP-binding protein Rheb

1

16

Small-scale

0.479

High

196311

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

1

Small-scale

0.479

High

196312

MOONR
Protein moonraker

1

2

High-throughput

0.479

High

196315

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

2

High-throughput

0.479

High

196317

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

196320

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

196329

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

196330

TTC8
Tetratricopeptide repeat protein 8

1

1

Small-scale

0.479

High

196339

BBS4
Bardet-Biedl syndrome 4 protein

1

1

Small-scale

0.479

High

196340

DNJC2
DnaJ homolog subfamily C member 2

1

4

High-throughput

0.479

High

196342

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

3

Small-scale

0.479

High

196344

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

1

High-throughput

0.479

High

196348

Q9H4D1
Protein kinase

1

2

High-throughput

0.479

High

196351

SP110
Sp110 nuclear body protein

1

2

High-throughput

0.479

High

196354

MYO10
Unconventional myosin-X

1

1

Small-scale

0.479

High

196355

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

196358

TECR
Very-long-chain enoyl-CoA reductase

1

1

Small-scale

0.479

High

196359

HACD3
Very-long-chain

1

2

Small-scale

0.479

High

196362

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

196365

HOOK1
Protein Hook homolog 1

1

2

High-throughput

0.479

High

196366

LEF1
Lymphoid enhancer-binding factor 1

1

2

Small-scale

0.479

High

196368

PRP19
Pre-mRNA-processing factor 19

1

1

High-throughput

0.479

High

196371

TRI33
E3 ubiquitin-protein ligase TRIM33

1

6

High-throughput

0.479

High

196375

IRS2
Insulin receptor substrate 2

1

2

Small-scale

0.479

High

136128

SCD
Stearoyl-CoA desaturase

1

0

Small-scale

0.458

High

196239

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

196242

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

Small-scale

0.458

High

196243

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

Small-scale

0.458

High

196244

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

196249

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

Small-scale

0.458

High

196250

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

196253

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

196265

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

Small-scale

0.458

High

196276

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

Small-scale

0.458

High

196278

PRC2A
Protein PRRC2A

1

0

High-throughput

0.458

High

196279

TSC2
Tuberin

1

0

Small-scale

0.458

High

196283

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

Small-scale

0.458

High

196299

PLD1
Phospholipase D1

1

0

High-throughput

0.458

High

196307

VAS1
V-type proton ATPase subunit S1

1

0

Small-scale

0.458

High

196321

COX15
Heme A synthase COX15

1

0

Small-scale

0.458

High

196322

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

196324

BBS7
Bardet-Biedl syndrome 7 protein

1

0

Small-scale

0.458

High

196325

BBS5
Bardet-Biedl syndrome 5 protein

1

0

Small-scale

0.458

High

196352

Q9HCK3
KIAA1569 protein

1

0

Small-scale

0.458

High

196357

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.458

High

196360

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

Small-scale

0.458

High

196361

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.458

High

196364

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.458

High

196286

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

196301

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

196326

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

196367

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.445

High

196252

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.437

High

196256

ALDOC
Fructose-bisphosphate aldolase C

1

1

Small-scale

0.437

High

196258

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

Small-scale

0.437

High

196267

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

Small-scale

0.437

High

196271

TCF7
Transcription factor 7

1

3

Small-scale

0.437

High

196274

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

Small-scale

0.437

High

196281

CDK9
Cyclin-dependent kinase 9

1

4

Small-scale

0.437

High

196295

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

Small-scale

0.437

High

196308

RB11B
Ras-related protein Rab-11B

1

9

Small-scale

0.437

High

196313

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

196316

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

Small-scale

0.437

High

196353

TF7L1
Transcription factor 7-like 1

1

2

Small-scale

0.437

High

196369

MAGD2
Melanoma-associated antigen D2

1

10

High-throughput

0.437

High

130351

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

Small-scale

0.249

Low

196240

CCNT1
Cyclin-T1

1

0

Small-scale

0.249

Low

196245

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

Small-scale

0.249

Low

196246

ATP5H
ATP synthase subunit d, mitochondrial

1

0

Small-scale

0.249

Low

196254

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

Small-scale

0.249

Low

196259

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

Small-scale

0.249

Low

196266

ATPD
ATP synthase subunit delta, mitochondrial

1

0

Small-scale

0.249

Low

196268

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

Small-scale

0.249

Low

196272

VATE1
V-type proton ATPase subunit E 1

1

0

Small-scale

0.249

Low

196275

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

Small-scale

0.249

Low

196280

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

Small-scale

0.249

Low

196284

ATP5I
ATP synthase subunit e, mitochondrial

1

0

Small-scale

0.249

Low

196285

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

Small-scale

0.249

Low

196304

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

Small-scale

0.249

Low

196309

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

Small-scale

0.249

Low

196310

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

Small-scale

0.249

Low

196314

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

196332

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.249

Low

196346

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

Small-scale

0.249

Low

196356

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

196376

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.249

Low

196378

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024