Protein: SYHM
Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)

Gene: SYHM, HARS2
Organism: Homo sapiens
Interactions: 154
UniProt ID: P49590

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004821 - histidine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

517879

HARS1
Histidine--tRNA ligase, cytoplasmic

4

13

High-throughput

0.895

High

499618

CH60
60 kDa heat shock protein, mitochondrial

3

5

High-throughput

0.667

High

829351

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.656

High

258680

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

1

High-throughput

0.628

High

829359

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

2

High-throughput

0.628

High

829249

SYHM
Histidine--tRNA ligase, mitochondrial

1

13

Small-scale

0.618

High

829263

GRSF1
G-rich sequence factor 1

3

0

Small-scale

0.613

High

829268

ICT1
Large ribosomal subunit protein mL62

2

1

High-throughput

0.611

High

829334

MTG2
Mitochondrial ribosome-associated GTPase 2

2

1

High-throughput

0.611

High

829338

ANLN
Anillin

2

1

High-throughput

0.611

High

602079

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

High-throughput

0.602

High

829251

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

829258

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.602

High

829289

RM21
Large ribosomal subunit protein bL21m

2

0

High-throughput

0.602

High

829347

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

0

High-throughput

0.602

High

829310

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

2

0

High-throughput

0.585

High

226848

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

829272

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

369187

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

160444

AURKA
Aurora kinase A

1

1

High-throughput

0.536

High

257950

DNJB6
DnaJ homolog subfamily B member 6

1

5

High-throughput

0.536

High

336852

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.536

High

815350

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

829261

AKP13
A-kinase anchor protein 13

1

1

High-throughput

0.536

High

829264

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.536

High

829281

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

2

High-throughput

0.536

High

829282

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

1

High-throughput

0.536

High

829290

DHB13
17-beta-hydroxysteroid dehydrogenase 13

1

2

High-throughput

0.536

High

829293

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.536

High

829295

MYLK4
Myosin light chain kinase family member 4

1

3

High-throughput

0.536

High

829299

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

829308

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

3

High-throughput

0.536

High

829342

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

1

High-throughput

0.536

High

829350

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

829356

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.536

High

829357

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.536

High

829260

BST2
Bone marrow stromal antigen 2

1

0

High-throughput

0.518

High

234103

FADS1
Acyl-CoA

1

1

High-throughput

0.515

High

130462

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.513

High

574272

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

671050

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.513

High

790239

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

829250

STA5B
Signal transducer and activator of transcription 5B

1

0

High-throughput

0.513

High

829265

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.513

High

829269

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.513

High

829271

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

829273

ACOT6
Acyl-coenzyme A thioesterase 6

1

0

High-throughput

0.513

High

829279

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

829292

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.513

High

829294

NUD13
NAD(P)H pyrophosphatase NUDT13, mitochondrial

1

0

High-throughput

0.513

High

829300

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.513

High

829301

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

829302

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

829313

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

829314

PDLI5
PDZ and LIM domain protein 5

1

0

High-throughput

0.513

High

829322

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

829323

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

829325

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.513

High

829326

NUDT9
ADP-ribose pyrophosphatase, mitochondrial

1

0

High-throughput

0.513

High

829327

PHF7
PHD finger protein 7

1

0

High-throughput

0.513

High

829340

F217B
Protein FAM217B

1

0

High-throughput

0.513

High

829345

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.513

High

829352

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.513

High

174714

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

417075

KCRM
Creatine kinase M-type

1

0

High-throughput

0.493

High

829317

DGAT2
Diacylglycerol O-acyltransferase 2

1

0

High-throughput

0.493

High

655169

IL1R2
Interleukin-1 receptor type 2

1

2

High-throughput

0.489

High

829255

LMNB2
Lamin-B2

1

2

High-throughput

0.489

High

829259

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.489

High

829337

MAGF1
Melanoma-associated antigen F1

1

2

High-throughput

0.489

High

829360

FADS3
Fatty acid desaturase 3

1

1

High-throughput

0.489

High

262757

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

270000

RF1M
Peptide chain release factor 1, mitochondrial

1

4

High-throughput

0.479

High

373879

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

440415

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

726656

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

777500

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

789711

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

803070

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

827303

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

829253

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

829256

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

829266

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

829270

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

829276

SYAM
Alanine--tRNA ligase, mitochondrial

1

6

High-throughput

0.479

High

829309

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

829311

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

829319

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

829328

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

829333

MTRFR
Mitochondrial translation release factor in rescue

1

4

High-throughput

0.479

High

829336

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

829339

BIRC6
Baculoviral IAP repeat-containing protein 6

1

3

Small-scale

0.479

High

829344

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

829346

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

829349

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

4

High-throughput

0.479

High

264870

MPPB
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.458

High

327386

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

486490

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

799180

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

829254

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

829257

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

829280

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

829288

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

829312

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

829331

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

829332

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

829341

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

829358

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

552218

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

650657

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

719958

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

829285

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

829287

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

829335

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

516004

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.328

High

829252

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.328

High

829304

F174A
Membrane protein FAM174A

2

0

High-throughput

0.328

High

829316

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

829324

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.328

High

829353

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

829354

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

829283

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

178434

STX7
Syntaxin-7

1

0

High-throughput

0.279

Low

218096

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.279

Low

245482

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

351632

PDYN
Proenkephalin-B

1

0

High-throughput

0.279

Low

595710

NTF3
Neurotrophin-3

1

0

High-throughput

0.279

Low

778569

PMEL
Melanocyte protein PMEL

1

0

High-throughput

0.279

Low

829262

TROAP
Tastin

1

0

High-throughput

0.279

Low

829267

TFDP2
Transcription factor Dp-2

1

0

High-throughput

0.279

Low

829274

ASTRB
Protein Aster-B

1

0

High-throughput

0.279

Low

829275

YIF1B
Protein YIF1B

1

0

High-throughput

0.279

Low

829277

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.279

Low

829278

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

829284

KLH17
Kelch-like protein 17

1

0

High-throughput

0.279

Low

829286

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.279

Low

829296

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.279

Low

829297

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.279

Low

829298

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.279

Low

829303

SRARP
Steroid receptor-associated and regulated protein

1

0

High-throughput

0.279

Low

829305

GPX8
Probable glutathione peroxidase 8

1

0

High-throughput

0.279

Low

829306

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.279

Low

829307

CD003
Uncharacterized protein C4orf3

1

0

High-throughput

0.279

Low

829315

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

829318

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

1

0

High-throughput

0.279

Low

829320

SERC2
Serine incorporator 2

1

0

High-throughput

0.279

Low

829329

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

High-throughput

0.279

Low

829330

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

829343

SEP11
Septin-11

1

0

High-throughput

0.279

Low

829348

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

829355

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.279

Low

829291

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

829321

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024