Protein: TLR2
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)

Gene: TLR2
Organism: Homo sapiens
Interactions: 85
UniProt ID: O60603

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001540 - amyloid-beta binding
GO:0001875 - lipopolysaccharide immune receptor activity
GO:0002224 - toll-like receptor signaling pathway
GO:0004888 - transmembrane signaling receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252301

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.893

High

252351

TLR1
Toll-like receptor 1

4

14

Small-scale

0.885

High

252313

CD14
Monocyte differentiation antigen CD14

3

10

Small-scale

0.834

High

252326

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

3

Small-scale

0.827

High

252372

TLR10
Toll-like receptor 10

3

15

Small-scale

0.821

High

252331

BMR1A
Bone morphogenetic protein receptor type-1A

2

20

High-throughput

0.811

High

252333

STA5A
Signal transducer and activator of transcription 5A

2

2

High-throughput

0.811

High

252298

TLR2
Toll-like receptor 2

2

14

Small-scale

0.786

High

252377

TLR6
Toll-like receptor 6

2

14

Small-scale

0.769

High

214358

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

2

20

Small-scale

0.754

High

252371

CLC7A
C-type lectin domain family 7 member A

2

7

Small-scale

0.754

High

252368

MYD88
Myeloid differentiation primary response protein MyD88

7

16

Small-scale

0.743

High

252304

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

4

High-throughput

0.698

High

252329

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.698

High

252344

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

2

High-throughput

0.698

High

252324

AVR2A
Activin receptor type-2A

1

20

High-throughput

0.691

High

252336

BLK
Tyrosine-protein kinase Blk

1

12

High-throughput

0.691

High

252369

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

20

High-throughput

0.691

High

252337

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.665

High

252379

LY96
Lymphocyte antigen 96

1

2

Small-scale

0.665

High

252339

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

3

3

Small-scale

0.664

High

252354

A16L1
Autophagy-related protein 16-1

3

1

Small-scale

0.656

High

252322

PGS1
Biglycan

1

20

Small-scale

0.647

High

252355

TM214
Transmembrane protein 214

2

2

High-throughput

0.628

High

252362

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

2

2

High-throughput

0.628

High

188585

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.618

High

252303

RASH
GTPase HRas

1

7

Small-scale

0.618

High

252305

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

5

Small-scale

0.618

High

252310

PGS2
Decorin

1

20

Small-scale

0.618

High

252311

LYN
Tyrosine-protein kinase Lyn

1

12

Small-scale

0.618

High

252328

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

1

Small-scale

0.618

High

252330

SFTPD
Pulmonary surfactant-associated protein D

1

14

Small-scale

0.618

High

252345

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.618

High

252375

CLC4M
C-type lectin domain family 4 member M

1

7

Small-scale

0.618

High

252378

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.618

High

252359

SFTA1
Pulmonary surfactant-associated protein A1

1

12

Small-scale

0.595

High

252352

TRIP6
Thyroid receptor-interacting protein 6

1

0

Small-scale

0.586

High

252374

TOLIP
Toll-interacting protein

1

3

Small-scale

0.578

High

252340

CXCR4
C-X-C chemokine receptor type 4

2

0

Small-scale

0.560

High

252361

TRI58
E3 ubiquitin-protein ligase TRIM58

1

3

Small-scale

0.552

High

252327

TMOD1
Tropomodulin-1

1

1

High-throughput

0.541

High

252353

SMAD1
Mothers against decapentaplegic homolog 1

1

1

High-throughput

0.541

High

252363

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

20

High-throughput

0.541

High

252360

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

20

High-throughput

0.536

High

252366

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

2

Small-scale

0.536

High

252316

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.518

High

252338

STX17
Syntaxin-17

1

0

High-throughput

0.518

High

252370

HEMGN
Hemogen

1

0

High-throughput

0.518

High

252376

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.518

High

252358

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

High-throughput

0.513

High

252373

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.513

High

252299

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

Small-scale

0.479

High

252306

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

252307

CY24B
NADPH oxidase 2

1

1

Small-scale

0.479

High

252308

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

252309

TBB5
Tubulin beta chain

1

3

Small-scale

0.479

High

252312

HS90B
Heat shock protein HSP 90-beta

1

4

Small-scale

0.479

High

252314

VIME
Vimentin

1

7

Small-scale

0.479

High

252318

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

252319

EF2
Elongation factor 2

1

1

Small-scale

0.479

High

252320

ENPL
Endoplasmin

1

4

Small-scale

0.479

High

252321

CD44
CD44 antigen

1

1

Small-scale

0.479

High

252325

1433T
14-3-3 protein theta

1

8

Small-scale

0.479

High

252332

HSPA9
Stress-70 protein, mitochondrial

1

12

Small-scale

0.479

High

252341

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

Small-scale

0.479

High

252342

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.479

High

252343

TBB4B
Tubulin beta-4B chain

1

3

Small-scale

0.479

High

252347

TBB2A
Tubulin beta-2A chain

1

3

Small-scale

0.479

High

252348

CIRBP
Cold-inducible RNA-binding protein

1

2

Small-scale

0.479

High

252349

DHX8
ATP-dependent RNA helicase DHX8

1

2

Small-scale

0.479

High

252350

IRF3
Interferon regulatory factor 3

1

13

Small-scale

0.479

High

252356

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

1

Small-scale

0.479

High

252357

TCAM1
TIR domain-containing adapter molecule 1

1

8

Small-scale

0.479

High

252364

TFG
Protein TFG

1

1

Small-scale

0.479

High

252365

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

252367

NEUR1
Sialidase-1

1

3

Small-scale

0.479

High

252300

SNAPN
SNARE-associated protein Snapin

1

0

Small-scale

0.458

High

252302

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

252323

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

Small-scale

0.458

High

252334

MRP
MARCKS-related protein

1

0

Small-scale

0.458

High

252335

TCPG
T-complex protein 1 subunit gamma

1

0

Small-scale

0.458

High

252346

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

Small-scale

0.457

High

252315

HMGB1
High mobility group protein B1

1

6

Small-scale

0.445

High

252317

CH60
60 kDa heat shock protein, mitochondrial

1

5

Small-scale

0.445

High


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Last updated: 11Aug2025